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Anti-osteoporotic drug trials should include Vitamin D – Oct 2023

Use of vitamin D with anti-osteoporotic drugs: are available clinical trials telling us the whole story?

Endocrine . 2023 Oct 10. doi: 10.1007/s12020-023-03551-z
Luigi di Filippo 1, Fabio Massimo Ulivieri 2, Ranuccio Nuti 3, Andrea Giustina 1

There is a strong rationale for using vitamin D in combination with anti-osteoporotic drugs. Still, available trials do not give clear indications in this setting, presenting a suboptimal and heavily inhomogeneous experimental design. Health authorities should revise requirements for using vitamin D in anti-osteoporotic drug trials to maximise their effect and produce reliable indications for clinical practice in this setting.

51 references
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152+ VitaminDWiki Osteoporosis pages with VITAMIN D in the title

This list is automatically updated

Items found: 156
Title Modified
Italian women taking Vitamin D (Osteoporosis, etc) - Dec 2022 06 Mar, 2024
Hip joint destroyed in months (rare) is associated with especially low Vitamin D – Feb 2024 29 Feb, 2024
Potassium helps bones by increasing the absorption of both Calcium and Vitamin D – Feb 2024 13 Feb, 2024
Osteoporosis treatment by zoledronic acid painful if low vitamin D (nomogram) – Oct 2023 16 Dec, 2023
Osteosarcopenia 4.5X more likely if low vitamin D - Dec 2023 08 Dec, 2023
Vitamin D Receptors in muscles decrease with age in those with Osteoporosis - 2018 20 Aug, 2023
Overview Fractures and vitamin D 11 Aug, 2023
Quick, free, self test of vitamin D deficiency 17 Jul, 2023
Osteoporosis consensus includes Vitamin D and Calcium (Ecuador) – June 2023 15 Jun, 2023
Vitamin D during pregnancy increased child’s bone mineral density – meta-analysis April 2023 27 Apr, 2023
Osteoporosis fought by Vitamin D and Testosterone in Caucasian men – March 2023 22 Apr, 2023
Bone mineral density improvement by Vitamin D plus fluoride is augmented by laser acupuncture – RCT March 2023 22 Mar, 2023
Osteoporosis guidelines mention vitamin D - Jan 2023 08 Jan, 2023
Vitamin A may thwart the ability of vitamin D to reduce risk of osteoporosis – June 2010 30 Oct, 2022
COVID-Osteoporosis association appears to be low Vitamin D – Oct 2022 29 Oct, 2022
Another Osteoporosis group fails to recommend Vitamin D, etc. (perhaps fears losing business) - Oct 2022 06 Oct, 2022
Fewer bone and stress fractures with vitamin D - many studies 25 Aug, 2022
Is it ethical to NOT give vitamin D in osteoporosis trials– NEJM Sept 2010 25 Jul, 2022
Perhaps higher risk of fracture if low BMD plus low vitamin D – July 2022 08 Jul, 2022
Consequences of Italy’s decision to restrict Vitamin D reimbursement for Osteoporosis prevention – April 2022 29 Apr, 2022
The clinician's guide to prevention and treatment of osteoporosis (vitamin D is mentioned) – April 2022 28 Apr, 2022
Genes that increase the risk of Osteoporosis: Vitamin D Receptor is number one in Asians– April 2022 23 Apr, 2022
Osteoporosis, periodontal and other diseases share a risk factor – low vitamin D – March 2022 05 Mar, 2022
Vitamin D and Calcium for Osteroporosis in France increased by 4X: 2007-2016 12 Nov, 2021
Vitamin D levels increasing 7 percent per year, bones denser in Japan (probably supplementation) - June 2015 12 Apr, 2021
History of Vitamin D from 500 million years ago to orthopaedic practice today – 2019 14 Mar, 2021
Low bone mineral density is inversely associated with both Vitamin D and Resistin (resistance to insulin) 15 Jan, 2021
Osteoporosis Risk varies with Vitamin D Receptor – three meta-analyses in 2020 25 Nov, 2020
Vitamin D treats Osteoporosis, but has problems it Calcium is not reduced (or changed) - Nov 2020 15 Nov, 2020
Chronic pain if osteoporosis and low vitamin D – June 2020 18 Jun, 2020
Increased risk of Osteoporosis if poor Vitamin D Receptor (UK males this time) – Sept 2019 01 Nov, 2019
Osteoporosis 3X higher risk of in white men having a poor Vitamin D receptor – Aug 2019 27 Aug, 2019
Osteoporosis is associated with genes such as the Vitamin D Receptor – July 2019 22 Aug, 2019
Female Colon Cancer survivors had 74 percent increased risk of osteoporosis (perhaps low vitamin D) – July 2019 29 Jul, 2019
Vitamin D is the most used anti-osteoporosis medication in senior homes in Australia – June 2019 19 Jun, 2019
Bone marrow foot oedema (rare pain in children, all were Vitamin D deficient) – May 2019 02 Jun, 2019
Hard bones, soft arteries, rather than vice versa (Vitamin D and Vitamin K) – March 2016 26 Apr, 2019
Osteoporosis treatment – Vitamin D is the most cost-effective – April 2019 21 Apr, 2019
Vitamin D, Calcium and protein very important to bone health – Sept 2015 27 Feb, 2019
Vitamin D receptors get worse with age with osteoporosis – Dec 2018 30 Dec, 2018
Osteoporosis 15 percent more likely if poor Vitamin D receptor – meta-analysis Dec 2018 11 Dec, 2018
Vitamin D helps treat Osteoporosis – Sept 2018 31 Oct, 2018
Osteoporosis treatment with Vitamin D – far healthier and 10X fewer afib events (vs bisphosphonates) – Oct 2018 30 Oct, 2018
Fractures are not a function of vitamin D genes – Aug 2018 04 Sep, 2018
Postmenopausal women need Vitamin D, protein and exercise to prevent loss of muscle and bone – Aug 2018 21 Aug, 2018
Osteoporosis treatment by semi-activated (nutritional) Vitamin D – Sept 2018 13 Jul, 2018
Korea proposes vitamin D of 20 ng, but notes 20ng increases osteo by 50 percent – Oct 2012 03 Jul, 2018
Osteomalacia (soft bones - ricket in children) – Vitamin D occurs 87 times in PDF, but not once in the abstract – March 2018 30 Jun, 2018
Vertebral fractures 9X more likely in HIV patients having low vitamin D – Dec 2017 22 Jun, 2018
Poor response to Osteoporosis medicine (risedronate) if vitamin D less than 16 ng – May 2018 09 May, 2018
Osteoporosis treatment with denosumab is helped by Vitamin D and Calcium – 2017 22 Feb, 2018
Osteoporosis and low grip strength both associated with low vitamin D – Feb 2018 13 Feb, 2018
Bisphosphonates 4.5 X more likely to work when vitamin D level above 33 ng – Sept 2011 12 Feb, 2018
Disc Degeneration in women is 1.7X more likely if poor Vitamin D Receptor – meta-analysis Jan 2017 04 Feb, 2018
Tibia pain (long term) is 20X more likely if low vitamin D (under 10 ng) – Jan 2018 05 Jan, 2018
Healthy bones need: Calcium, Vitamin D, Magnesium, Silicon, Vitamin K, and Boron – 2012 22 Oct, 2017
Better total hip replacement if have high vitamin D 26 Aug, 2017
Osteoporosis 4X more likely if poor gut (probably poor vitamin D absorption) – Aug 2017 22 Aug, 2017
Bone loss (following gastric cancer) reduced by 16,000 IU of vitamin D every 10 days – Aug 2017 03 Aug, 2017
American College of Rheumatology Guidelines finally include Vitamin D – June 2017 07 Jun, 2017
Overview Osteoporosis and vitamin D 07 Jun, 2017
Vitamin D and biophospates are needed after organ transplant – Aug 2011 25 Mar, 2017
Bone diseases related to many Vitamin D diseases – June 2016 11 Mar, 2017
Osteoporosis of Indian men in their 60’s (perhaps low vitamin D, K, and Mg) – Nov 2016 05 Dec, 2016
Vitamin D Receptor genes bb and BB and Osteoporosis, esp. for blacks – meta-analysis Nov 2012 05 Dec, 2016
Osteoporosis helped by Vitamin D, still not willing to recommend exact dose size – Nov 2016 23 Nov, 2016
Osteoporosis 2.8 X more likely if Vitamin D receptor (VDR) genes altered – Aug 2013 12 Nov, 2016
Alcoholics with low vitamin D get more bone fractures -Jan 2011 01 Nov, 2016
20X increase in vitamin D sold and 36 percent decrease in osteoporosis business in Australia – Nov 2013 12 Oct, 2016
COPD, Osteoporosis, and low Vitamin D – Sept 2016 14 Sep, 2016
Bones not helped much by vitamin D (low dose or short term) National Osteoporosis Foundation – Feb 2016 10 Feb, 2016
Osteoporosis vitamin D workshop - but still test BMD first - Oct 2010 19 Jan, 2016
Osteoporosis is associated with more than vitamin D genes – Jan 2016 03 Jan, 2016
Hypothesis: Vitamin D is the link between Osteoporosis, Obesity, and Diabetes – April 2014 03 Dec, 2015
Yet again, 800 IU of vitamin D was found to be barely enough to help bones – Lancet Oct 2013 12 Nov, 2015
2.8X higher risk of osteoporosis if COPD and modified vitamin D receptor genes – Sept 2015 09 Sep, 2015
800 IU Vitamin D proven again to not be enough to stop bone loss - Aug 2015 03 Aug, 2015
Spectacular improvement in vitamin D status in elderly osteoporotic women – June 2015 25 Jun, 2015
Osteoporosis groups hide their synthetic vitamin D recommendations behind 40 dollar paywall – May 2015 03 May, 2015
Hip fractures reduced 30 percent with 800 IU of vitamin D – meta-analysis July 2012 16 Mar, 2015
Cochrane review finds that Vitamin D and Calcium treat osteoporosis – Feb 2010 16 Mar, 2015
The role of vitamin D in osteoporosis – Jan 2015 18 Jan, 2015
Osteoporosis due to antiepileptic drugs: placebo including Vitamin D helped 69 percent, placebo with risedronate helped 70% – Sept 2013 06 Jan, 2015
Vitamin D and Bone Health – UK National Osteoporosis Society – April 2013 29 Nov, 2014
Osteoporosis Society UK: 20 ng vitamin D is sufficient, loading dose 300,000 IU – Sept 2014 17 Sep, 2014
National Osteoporosis Society of UK declares that 12 ng of vitamin D is enough – June 2013 17 Sep, 2014
Vitamin D can quickly deal with Osteoporosis in the very old – Europe working group review – July 2014 16 Jul, 2014
Virtually all vitamin D testing not associated with a symptom, but 10 percent had osteoporosis – April 2014 09 Jul, 2014
Vitamin D testing typically not needed, but in 9 cases it is – April 2012 16 Apr, 2014
Fractures reduced with any amount of vitamin D and some Calcium - Cochraine April 2014 14 Apr, 2014
Osteoporsis doctors need to prescribe 800 IU of vitamin D - study proposed of how to tell them – May 2012 14 Apr, 2014
Osteoporosis quality of life better if more than 20 ng of vitamin D – Jan 2014 28 Jan, 2014
CureTogether Vitamin D symptoms, treatments, and causes 25 Dec, 2013
Vitamin D, K2, Magnesium, etc increase bone density when taking together– Jan 2012 28 Nov, 2013
Safety profile of Osteoporosis drugs, including vitamin D – review Nov 2013 07 Nov, 2013
World Osteoporosis Day sponsored by Big Pharma – does not give good sun or vitamin D info Oct 20 2013 21 Oct, 2013
During brown bear hibernation Vitamin D3 decreases but D2 increases (surprise) – June 2011 14 Oct, 2013
Both Vitamin D and Calcium are needed to reduce bone loss – RCT Sept 2013 29 Sep, 2013
8X higher Osteoporosis risk if high level of vitamin A, vitamin D important too – Feb 2013 31 Jul, 2013
Vitamin D intervention stopped bone loss in those mice getting too much alcohol – Aug 2012 31 Jul, 2013
22 percent more bone cracking found with low vitamin D – July 2013 11 Jul, 2013
4X increase in osteoporosis visits, but vitamin D information is still not available – May 2013 31 May, 2013
COPD – Bone Metabolism – Osteoporosis – Vitamin D appear related – Mar 2011 02 May, 2013
PREVENTIVE Task force has decided to not PREVENT osteoporosis with vitamin D - 2011 26 Feb, 2013
Osteoporosis spot therapies: vitamin D with Calcium was the most popular – Feb 2013 14 Feb, 2013
3D images of bone plus position statements on Osteo and vitamin D – 2012 17 Jan, 2013
European Osteo group recommends 20-50 ng of vitamin D – Jan 2013 17 Jan, 2013
Low Vitamin D or Vitamin K2 may be a cause of Hypertension and Osteoporosis – Nov 2012 30 Nov, 2012
Prefer more than 30 ng of Vitamin D and 700 mg Calcium to treat Osteoporosis – Mar 2011 10 Nov, 2012
Osteoporotic fractures marginally reduced with 800 IU of vitamin D and some vitamin K2 – March 2012 26 Oct, 2012
Low vitamin D with high vitamin A associated with increased risk of osteoporosis – June 2010 26 Oct, 2012
HIV patients had bone loss and less than 20 ng of vitamin D – Sept 2010 26 Oct, 2012
HIV leads to low vitamin D which leads to osteoporosis – a growing problem May 2012 26 Oct, 2012
Some immunity diseases associated with low vitamin D and Osteoporosis – Nov 2011 17 Oct, 2012
Vitamin D was not a predictor of osteoporosis fractures – Sept 2012 11 Oct, 2012
Hip fracture and vitamin D – Health ABC study – May 2012 28 Sep, 2012
Osteoporosis medicine teriparatide increased active vitamin D by 25 pcnt– RCT June 2012 15 Sep, 2012
Osteoporosis and vitamin D are important in men too – 10 years after women – Aug 2012 08 Aug, 2012
Hardly any children had enough vitamin D before bone surgery – April 2011 06 Aug, 2012
Yes, need more than 400 IU of vitamin D to strengthen bones 27 Jun, 2012
Bone density of children did not improve with 3 month of vitamin D – Oct 2010 25 Jun, 2012
Fewer falls and fractures as vitamin D is increased – 1800 to 4000 IU July 2010 24 Jun, 2012
Majority of animal bone fractures healed more quickly with vitamin D – May 2011 24 Jun, 2012
Only half of bone fracture patients were given treatment, the most popular being vitamin D – Dec 2011 24 Jun, 2012
Just 700 IU of vitamin D and 700 mg of Calcium reduces falls and fractures – Nov 2010 23 Jun, 2012
Vitamin D for elderly 800 to 2000 IU - Osteoporosis Canada - Sept 2010 23 Jun, 2012
Vitamin D is the first of three ways to make unbreakable bones – Oct 2011 17 Apr, 2012
Review of vitamin D pathways to bone health - July 2010 18 Jan, 2012
Osteoporosis increasing and vitamin D decreasing in Middle East - Oct 2011 25 Dec, 2011
Calcium and vitamin D supplements after hip fracture reduced death rate by 25% – Feb 2011 19 Nov, 2011
Should stock-up on vitamin D if having surgery due to fragile bones – Jan 2011 04 Nov, 2011
What are people taking vitamin D for - Feb 2011 06 Oct, 2011
Some immunodeficiency diseases associated with low vitamin D and increased Osteoporosis – Nov 2011 30 Sep, 2011
6500 IU vitamin D and 1000 mg Calcium daily did not improve bone density – Sept 2011 14 Sep, 2011
Lowest cost osteoporosis treatment was vitamin D and Calcium – Oct 2010 03 Aug, 2011
MS reduces vitamin D which then causes osteoporosis – July 2011 30 Jul, 2011
Calcium citrate and more than 800 IU of vitamin D to treat Osteoporosis – Mar 2011 14 Jun, 2011
Should orthopaedic surgeons prevent future fractures with vitamin D etc – June 2011 20 May, 2011
BMD improved with 800 mg Calcium, 400 IU of vitamin D, and 100 ug of vitamin K – April 2011 04 Apr, 2011
2800 IU vitamin D daily did not decrease bone loss for those with MS – March 2011 31 Mar, 2011
Better Hip Resurfacing after vitamin D levels had been normalized – March 2011 20 Mar, 2011
National Osteoporosis Foundation on Vitamin D - more than 30 ng - 2010 02 Jan, 2011
Suboptimal appreciation by Asian physicians of vitamin D for bone health – Oct 2010 27 Oct, 2010
Low vitamin D may account for half of the reasons for osteomalacia – Oct 2010 21 Oct, 2010
4000 IU Vitamin D intervention helped elderly bones – March 2010 16 Oct, 2010
Round-table discussion of vitamin D deficiency – May 2010 04 Oct, 2010
Low Calcium and vitamin D makes osteomalacia but either makes osteoporosis – Sept 2010 28 Sep, 2010
Vitamin D helps health, perhaps avoid having more than 40ng/ml -May 2010 27 Sep, 2010
Osteoporosis medicines - several include vitamin D 26 Sep, 2010
890 IU of vitamin D and 1200 mg Calcium improved bone density – July 2010 18 Jul, 2010
Will doses of vitamin D up to 6000 IU reduce osteoporosis in black women - July 2010 08 Jul, 2010
Osteoporosis is due to estrogen until late in life when vitamin D becomes important – May 2010 02 Jul, 2010
Patients like me survey found vitamin D to be number one supplement 27 Jun, 2010
Seniors needed 2000 to 3000 IU of vitamin D to increase serum levels – June 2010 18 Jun, 2010
WHO states that Vitamin D and Calcium reduces Osteoporosis by 30% - 2006 26 May, 2010
More vitamin D needed to prevent osteoporosis in seniors – May 2010 11 May, 2010
Anti-osteoporotic drug trials should include Vitamin D – Oct 2023        
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