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Bone loss (following gastric cancer) reduced by 16,000 IU of vitamin D every 10 days – Aug 2017

Bone health in long-term gastric cancer survivors: A prospective study of high-dose vitamin D

J Bone Miner Metab. 2017 Aug 1. doi: 10.1007/s00774-017-0856-1. [Epub ahead of print]
supplementation using an easy administration scheme.
Climent M1, Pera M1, Aymar I2,3,4, Ramón JM1, Grande L1, Nogués X5,6,7.

VitaminDWiki

Bone loss due to many causes is substantially reduced by Vitamin D, Magnesium, Vitamin K2 and protein

Pages listed in BOTH the categories Bone and Magnesium

Pages listed in BOTH the categories Bone and Vitamin K2


Personal note:
Founder of VitaminDWiki takes 50,000 IU every 5 days as well as Magnesium and Vitamin K2


Bone disease in long-term survivors after gastric cancer resection has received little research attention. This study aimed to investigate bone health after curative resection of gastric cancer and the consequences of high-dose vitamin D supplementation in patients with low levels of 25-(OH)-vitamin D. Disease-free patients at least 24 months after gastric cancer resection represented the study cohort. Serum markers of bone metabolism were assessed at baseline and at 3 and 12 months. Bone mineral density and presence of fractures were assessed by X-ray at baseline. Patients with 25-(OH)-vitamin D ≤30 ng/mL at baseline received 16,000 IU of vitamin D3 every 10 days during the 1-year follow-up.

Forty patients were included in the study. Mean time from surgery was 48.9 (24-109) months. Vitamin D insufficiency and secondary hyperparathyroidism were observed in 38 and 20 patients, respectively. Densitometry showed osteoporosis in 14 women and seven men and prevalent fractures in 12 women and six men at baseline. After 3 months of vitamin D supplementation, 35 patients reached values of 25-(OH)-vitamin D over 30 ng/mL.

After 12 months, 38 patients were in the normal range of 25-(OH)-vitamin D. At the same time, iPTH levels and markers of bone turnover (C-terminal cross-linked telopeptide of type-I collagen, serum concentrations of bone-specific alkaline phosphatase and osteocalcin) significantly decreased after vitamin D intervention. Oral administration of high doses of vitamin D is easily implemented and restored 25-(OH)-vitamin D and iPTH values, which are frequently disturbed after gastric cancer resection.

PMID: 28766134 DOI: 10.1007/s00774-017-0856-1

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