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Poor response to Osteoporosis medicine (risedronate) if vitamin D less than 16 ng – May 2018

Factors associated with inadequate responses to risedronate in Japanese patients with osteoporosis.

J Bone Miner Metab. 2018 May 8. doi: 10.1007/s00774-018-0931-2. [Epub ahead of print]
Okazaki R1, Muraoka R2, Maehara M2, Inoue D3.
1 Third Department of Medicine, Teikyo University Chiba Medical Center Japan, 3426-3, Anesaki, Ichihara-shi, Chiba, 299-0111, Japan. rokazaki at med.teikyo-u.ac.jp.
2 EA Pharma Co., Ltd., Tokyo, Japan.
3 Third Department of Medicine, Teikyo University Chiba Medical Center Japan, 3426-3, Anesaki, Ichihara-shi, Chiba, 299-0111, Japan.

VitaminDWiki

Overview Osteoporosis and vitamin D contains the following summary

  • FACT: Bones need Calcium (this has been known for a very long time)
  • FACT: Vitamin D improves Calcium bioavailability (3X ?)
  • FACT: Should not take > 750 mg of Calcium if taking lots of vitamin D (Calcium becomes too bio-available)
  • FACT: Adding vitamin D via Sun, UV, or supplements increased vitamin D in the blood
  • FACT: Vitamin D supplements are very low cost
  • FACT: Many trials, studies. reviews, and meta-analysis agree: adding vitamin D reduces osteoporosis
  • FACT: Toxic level of vitamin D is about 4X higher than the amount needed to reduce osteoporosis
  • FACT: Co-factors help build bones.
  • It appears that to TREAT Osteoporosis:
  •        Calcium OR vitamin D is ok
  •        Calcium + vitamin D is good
  •        Calcium + vitamin D + other co-factors is great
  • CONCLUSION: To PREVENT many diseases, including Osteoporosis, as well as TREAT Osteoporosis
  • Category Osteoporosis has 175 items
  • Category Bone Health has 245 items


Osteoporosis category includes the following

Pages in BOTH the categories Osteoporosis and Meta-analysis

https://vitamindwiki.com/tiki-editpage.php?page=Osteoporosis
Pages listed in BOTH of the categories Genetics and Osteoporosis

20 Most-visited pages in Osteoporosis category in VitaminDWiki

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Overviews
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1328 Overview Osteoporosis and vitamin D 30202
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Overviews
3424 Osteoporosis 22016
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Category
2126 Osteoporosis increasing and vitamin D decreasing in Middle East - Oct 2011 12397
25 Dec, 2011 12:22
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2366 Vitamin D, K2, Magnesium, etc increase bone density when taking together– Jan 2012 12229
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1121 Alcoholics have osteoporosis – Nov 2010 11506
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6694 High dose vitamin reduced pain of fibromyalgia, osteoarthritis, and rheumatoid arthritis - July 2015 11157
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535 Better total hip replacement if have high vitamin D 10584
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1092 Suboptimal appreciation by Asian physicians of vitamin D for bone health – Oct 2010 10568
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4647 Yet again, 800 IU of vitamin D was found to be barely enough to help bones – Lancet Oct 2013 8716
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3122 Calcium and bone disorders in pregnancy – May 2012 8617
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4553 Causes, consequences, and treatment of osteoporosis in men– Aug 2013 6875
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2088 CureTogether Vitamin D symptoms, treatments, and causes 6617
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1063 Fewer falls and fractures as vitamin D is increased – 1800 to 4000 IU July 2010 6613
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Osteoporosis
Falls and Fractures
1000 Review of vitamin D pathways to bone health - July 2010 6493
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6703 Calcium supplements proven to NOT reduce fractures, but are proven to INCREASE heart problems – July 2015 6435
24 Jul, 2015 16:51
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Vitamin D and Calcium
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Falls and Fractures
969 Vitamin D for elderly 800 to 2000 IU - Osteoporosis Canada - Sept 2010 6307
23 Jun, 2012 02:17
admin About D - more info.
Osteoporosis
Meta-analysis of Vitamin D
Vitamin D in Canada
3490 Vitamin D Receptor genes bb and BB and Osteoporosis, esp. for blacks – meta-analysis Nov 2012 5772
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Genetics
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Vitamin D Receptor


Here are all of the articles


Factors associated with an inadequate response (IR) to bisphosphonates have been reported in many countries, but not in Japan, where the approved dose is half the global dose. We analyzed factors associated with IR to risedronate in Japanese patients with osteoporosis. This was a post hoc analysis of 1261 Japanese osteoporosis patients who received risedronate for 1 year in phase III trials. IR was defined as more than one new vertebral fracture (VF) and/or negative change in lumbar spine bone mineral density (BMD) at 1 year. Various baseline and follow-up variables were examined for potential contribution to IR. Of the 1261 subjects, 118 exhibited an IR. At baseline, IR was associated with a higher BMD, lower levels of bone turnover markers (BTM) (serum bone-specific alkaline phosphatase, urinary N-terminal telopeptide of type 1 collagen and C-terminal telopeptide of type 1 collagen), and serum 25-hydroxyvitamin D [25(OH)D] below 16 ng/mL.
BTM changes were blunted at 6 months in subjects with IR. On simple regression analysis, all the above variables and poor drug adherence were associated with an IR. On multivariate regression analysis, factors associated with IR were high BMD, vitamin D deficiency at baseline and low BTM at baseline, or a decreased BTM response at 6 months.
Low serum 25(OH)D and BTM as well as high BMD at baseline were independent predictors of an IR to risedronate in Japan. These results emphasize the importance of the assessment of serum 25(OH)D and BTM in the management of osteoporosis with bisphosphonates.

PMID: 29737412 DOI: 10.1007/s00774-018-0931-2

Created by admin. Last Modification: Wednesday May 9, 2018 13:49:28 GMT-0000 by admin. (Version 2)
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