Vitamin D and bisphosphonates therapies for osteoporosis are associated with different risks of atrial fibrillation in women: A nationwide population-based analysis
Medicine: October 2018 - Vol 97 - # 43 - p e12947, doi: 10.1097/MD.0000000000012947
Yang, Hung-Yu, MD, MSa,b,c; Huang, Jen-Hung, MDa,c; Chiu, Hung-Wen, PhDb,*; Lin, Yung-Kuo, MD, PhDa,c; Hsu, Chien-Yeh, PhDd,e; Chen, Yi-Jen, MD, PhDa,f,*
Observation of 20,788 female osteoporosis patients,
525 received bisphosphonates, 354 received vitamin D (dose size unknown)
Overview Osteoporosis and vitamin D contains the following summary
- FACT: Bones need Calcium (this has been known for a very long time)
- FACT: Vitamin D improves Calcium bioavailability (3X ?)
- FACT: Should not take > 750 mg of Calcium if taking lots of vitamin D (Calcium becomes too bio-available)
- FACT: Adding vitamin D via Sun, UV, or supplements increased vitamin D in the blood
- FACT: Vitamin D supplements are very low cost
- FACT: Many trials, studies. reviews, and meta-analysis agree: adding vitamin D reduces osteoporosis
- FACT: Toxic level of vitamin D is about 4X higher than the amount needed to reduce osteoporosis
- FACT: Co-factors help build bones.
- It appears that to TREAT Osteoporosis:
- Calcium OR vitamin D is ok
- Calcium + vitamin D is good
- Calcium + vitamin D + other co-factors is great
- CONCLUSION: To PREVENT many diseases, including Osteoporosis, as well as TREAT Osteoporosis
- Category Osteoporosis has
- Category Bone Health has
Osteoporosis category includes the following
170 items in category - see also Overview Osteoporosis and vitamin D
- Overview Fractures and vitamin D
- Bone - Health
- Search BMD OR Bone Mineral Density 2240 results as of May 2018
- Search VitaminDWiki for OSTEOPENIA 808 items as of May 2018
Pages in BOTH the categories Osteoporosis and Meta-analysis
- Fractures reduced with any amount of vitamin D and some Calcium - Cochraine April 2014
- Vitamin D Receptor genes bb and BB and Osteoporosis, esp. for blacks – meta-analysis Nov 2012
- Hip fractures reduced 30 percent with 800 IU of vitamin D – meta-analysis July 2012
- Vitamin D for elderly 800 to 2000 IU - Osteoporosis Canada - Sept 2010
- Hip fractures in India - editorial with recommendation - Sept 2010
- Cochrane review finds that Vitamin D and Calcium treat osteoporosis – Feb 2010
Osteoporosis and atrial fibrillation (AF) are common in post-menopausal women. Vitamin D and bisphosphonates are widely used to treat osteoporosis, and these may have different effects on the risk of AF.
The goal of this study was to evaluate whether different agents for treating osteoporosis modulate the risk of AF in a population-based database.
We identified 20,788 female patients suffering from osteoporosis who were or were not treated with vitamin D or bisphosphonates using the Taiwan National Health Insurance nationwide database from 2000 to 2008 and followed them up for 5 consecutive years to determine if they had a new diagnosis of AF after the diagnosis of osteoporosis.
There were 14 (2.67%) new AF diagnoses in osteoporosis patients treated with bisphosphonates, one (0.28%) new AF diagnosis in patients treated with vitamin D, and 279 (1.40%) new AF diagnoses in patients who were not treated with vitamin D or bisphosphonates (neither group). Osteoporosis patients who received bisphosphonates showed a higher incidence of AF occurrence than those that were not treated with bisphosphonates (P = .015). In contrast, 1 patient who received vitamin D had a new diagnosis of AF during the study period; thus, the incidence was significantly lower than that in the patients treated with bisphosphonates (P = .007). In addition, the patients who were treated with vitamin D had a lower incidence of AF than did those who were not treated with either vitamin D or bisphosphonates (P = .074). Kaplan–Meier analysis also showed a significant difference in AF occurrence in different groups during the 5-year follow-up (P = .010).
Different treatment for osteoporosis may carry diverse risks of AF occurrence. Vitamin D may have potential beneficial effects of reducing AF occurrence in osteoporosis patients.
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