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Hypothesis: Vitamin D is the link between Osteoporosis, Obesity, and Diabetes – April 2014

Int. J. Mol. Sci. 2014, 15(4), 6569-6591; doi:10.3390/ijms15046569 (doi registration under processing)
Flávia Galvão Cândido flaviagcandido at hotmail.com and Josefina Bressan
Laboratory of Body Composition and Energy Metabolism, Departamento de Nutrição e Saúde-CCB II, Universidade Federal de Viçosa, Avenida PH Rolfs, s/n, Viçosa, MG 36570-900, Brazil
(This article belongs to the Section Bioactives and Nutraceuticals)

Vitamin D (1,25(OH)2D3) is a steroid hormone that has a range of physiological functions in skeletal and nonskeletal tissues, and can contribute to prevent and/or treat osteoporosis, obesity, and Type 2 diabetes mellitus (T2DM). In bone metabolism, vitamin D increases the plasma levels of calcium and phosphorus, regulates osteoblast and osteoclast the activity, and combats PTH hypersecretion, promoting bone formation and preventing/treating osteoporosis. This evidence is supported by most clinical studies, especially those that have included calcium and assessed the effects of vitamin D doses (≥800 IU/day) on bone mineral density. However, annual megadoses should be avoided as they impair bone health.

Recent findings suggest that low serum vitamin D is the consequence (not the cause) of obesity and the results from randomized double-blind clinical trials are still scarce and inconclusive to establish the relationship between vitamin D, obesity, and T2DM.

Nevertheless, there is evidence that vitamin D

  • inhibits fat accumulation,
  • increases insulin synthesis and
  • preserves pancreatic islet cells,
  • decreases insulin resistance and
  • reduces hunger, favoring obesity and T2DM control.

To date, there is not enough scientific evidence to support the use of vitamin D as a pathway to prevent and/or treat obesity and T2DM.

Figure 2


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See also VitaminDWiki

see wikipage: http://www.vitamindwiki.com/tiki-index.php?page_id=1817

Pages listed in BOTH Obesity AND Diabetes

Pages listed in BOTH Meatabolic Syndrome AND Diabetes

Pages listed in BOTH Osteoporosis AND Diabetes

See also web

Attached files

ID Name Comment Uploaded Size Downloads
6209 Mechanisms and evaluation Dec 2015.pdf PDF 2015 admin 03 Dec, 2015 13:52 1.26 Mb 979
3819 Osteoporosis obesity diabetes.jpg admin 17 Apr, 2014 13:45 94.02 Kb 2445
3818 Vitamin D Link between Osteoporosis, Obesity, and Diabetes.pdf PDF 2014 admin 17 Apr, 2014 13:44 366.38 Kb 1392