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Diabetics and prediabetics helped by 5,000 IU of Vitamin D for 6 months– RCT July 2019

Effects of 6-month vitamin D supplementation on insulin sensitivity and secretion: a randomized, placebo-controlled trial

European Journal of Endocrinology DOI: https://doi.org/10.1530/EJE-19-0156


Note: Non-daily dosing better than daily (as used by this study) for Diabetes etc.

Items in both categories Diabetes and non-daily intervention are listed here:

Magnesium also helps diabetes

Omega-3 also helps diabetes

Vitamin D Receptor activation should also help Diabetes

Overview Diabetes and vitamin D contains the following

  • Diabetes is 5X more frequent far from the equator
  • Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
  • Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
  • Sedentary people get less sun / Vitamin D
  • Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
  • Elderly get 4X less vitamin D from the same amount of sun
        Elderly also spend less time outdoors and have more clothes on
  • All items in category Diabetes and Vitamin D 541 items: both Type 1 and Type 2

Vitamin D appears to both prevent and treat diabetes

Number of articles in both categories of Diabetes and:
'This list is automatically updated''

  • Dark Skin 24;   Intervention 56;   Meta-analysis 38;   Obesity 35;  Pregnancy 44;   T1 (child) 39;  Omega-3 11;  Vitamin D Receptor 24;  Genetics 12;  Magnesium 28    Click here to see details

Some Diabetes studies

50 ng of Vitamin D fights Diabetes

T1 Diabetes


Diabetes, Metabolic Syndrome and Magnesium - many studies

Diabetic Epidemic

  • Step back to 1994. Suppose an epidemic struck the United States, causing blindness, kidney failure, and leg amputations in steadily increasing numbers.
    Suppose that in less than a decade's time, the epidemic had victimized one out of every eight people
    That epidemic is real, and its name is diabetes, now the nation's sixth leading cause of death.
    Chart from the web (2018?)

Diabetes leads to many diseases - need to restore the vitamin D levels, even if it not help diabetes directly
Diabetes ==> Cognitive impairment
Diabetes ==> Vertebral fracture in men only
Diabetes ==> Rheumatoid Arthritis
Diabetes ==> Pancreatic Cancer
Diabetes ==> Alzheimer's
Depression <==> Diabetes

 Download the PDF from VitaminDWiki

Objective: To determine whether vitamin D3 supplementation improves insulin sensitivity, using the hyperinsulinemic-euglycemic clamp.

Design: This single-center, double-blind, placebo-controlled trial randomized 96 participants at high risk of diabetes or with newly diagnosed type 2 diabetes to vitamin D3 5,000 IU daily or placebo for 6 months.

Methods: We assessed at baseline and 6 months: 1) primary aim: peripheral insulin sensitivity (M-value using a 2-h hyperinsulinemic-euglycemic clamp); 2) secondary aims: other insulin sensitivity (HOMA2%S, Matsuda) and insulin secretion (insulinogenic index, C-peptide area under the curve, HOMA2-B) indices using a 2h-oral glucose tolerance test (OGTT); B-cell function (disposition index: M-value x insulinogenic index); fasting and 2-h glucose post-OGTT; HbAic; anthropometry.

Results: Baseline characteristics were similar between groups (% or mean±SD): women 38.5%; age 58.7±9.4 years; BMI 32.2±4.1 kg/m2; prediabetes 35.8%; diabetes 20.0%; 25- hydroxyvitamin D (25(OH)D) 51.1±14.2 nmol/L. At 6 months, mean 25(OH)D reached 127.6±26.3 nmol/L and 51.8±16.5 nmol/L in the treatment and placebo groups, respectively (p<0.001). A beneficial effect of vitamin D3 compared with placebo was observed on M- value (mean change (95% CI): 0.92 (0.24 to 1.59) versus -0.03 (-0.73 to 0.67); p=0.009) and disposition index (mean change (95% CI): 267.0 (-343.4 to 877.4) versus -55.5 (-696.3 to 585.3); p=0.039) after 6 months. No effect was seen on other outcomes.

Conclusions: In individuals at high risk of diabetes or with newly diagnosed type 2 diabetes, vitamin D supplementation for 6 months significantly increased peripheral insulin sensitivity and B-cell function, suggesting that it may slow metabolic deterioration in this population.

Created by admin. Last Modification: Monday July 29, 2019 15:12:49 GMT-0000 by admin. (Version 6)

Attached files

ID Name Comment Uploaded Size Downloads
12399 Diabetes 6 months 5,000 IU.jpg admin 29 Jul, 2019 52.41 Kb 783
12398 Diabetes 5,000 IU RCT.pdf admin 29 Jul, 2019 655.29 Kb 662