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Innate immune suppression by SARS-CoV-2 mRNA vaccinations - April 2022

Innate immune suppression by SARS-CoV-2 mRNA vaccinations: The role of G-quadruplexes, exosomes, and MicroRNAs

Food and Chemical Toxicology 164 (2022) 113008 https://doi.org/10.10167j.fct.2022.113008
Stephanie Seneffa’*, Greg Nigh b, Anthony M. Kyriakopoulos c, Peter A. McCullough d

  • a Computer Science and Artificial Intelligence Laboratory, MIT, Cambridge, MA, USA, 02139
  • b Immersion Health, Portland, OR, 97214, USA
  • c Research and Dev., Nasco AD Biotechnology Laboratory, Dept of Research and Dev., Sachtouri 11, 18536, Piraeus, Greece
  • d Truth for Health Foundation, Tucson, AZ, USA

The mRNA SARS-CoV-2 vaccines were brought to market in response to the public health crises of Covid-19. The utilization of mRNA vaccines in the context of infectious disease has no precedent. The many alterations in the vaccine mRNA hide the mRNA from cellular defenses and promote a longer biological half-life and high production of spike protein. However, the immune response to the vaccine is very different from that to a SARS-CoV-2 infection. In this paper, we present evidence that vaccination induces a profound impairment in type I interferon signaling, which has diverse adverse consequences to human health. Immune cells that have taken up the vaccine nanoparticles release into circulation large numbers of exosomes containing spike protein along with critical microRNAs that induce a signaling response in recipient cells at distant sites. We also identify potential profound disturbances in regulatory control of protein synthesis and cancer surveillance. These disturbances potentially have a causal link to neurodegenerative disease, myocarditis, immune thrombocytopenia, Bell’s palsy, liver disease, impaired adaptive immunity, impaired DNA damage response and tumorigenesis. We show evidence from the VAERS database supporting our hypothesis. We believe a comprehensive risk/benefit assessment of the mRNA vaccines questions them as positive contributors to public health.
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PDF Table of Contents

1 Introduction
2 Interferons: an overview with attention to cancer surveillance
3 Considerations in the design of mRNA vaccines
4 GC enrichment and potential G4 (pG4) structures in vaccine mRNAs
5 Type I IFNs and COVID-19
6 Are the methylation strategies for cellular housekeeping generally omitted by vaccine mRNAs?
7 Exosomes and MicroRNAs
8 Impaired DNA repair and adaptive immunity
9 Reactivation of va rice lb-zoster
10 Immune thrombocytopenia
11 PPAR-a, sulfatide and liver disease
12 Guiltain Barré syndrome and neurologic injury syndromes
13 Bell's palsy
14 Myocarditis
15 Considerations regarding the Vaccine Adverse Event Reporting System (VAERS)
15.1 VAERS data indicative of nerve damage and vagus nerve involvement
15.2 VAERS data on the heart and liver
15.3 VAERS data related to thrombosis
15.4 VAERS data related to neurodegenerative disease
15.5 VAERS signal for cancer
16 Conclusions

VAERS 2021 - Many


VAERS 2021 - Liver


VAERS 2021 - Neuro


VAERS 2021 - Cancer



There has been an unwavering message about the safety and efficacy of mRNA vaccinations against SARS-CoV-2 from the public health apparatus in the US and around the globe. The efficacy is increasingly in doubt, as shown in a recent letter to the Lancet Regional Health by Günter Kampf (2021b). Kampf provided data showing that the vaccinated are now as likely as the unvaccinated to spread disease. He concluded: “It appears to be grossly negligent to ignore the vaccinated population as a possible and relevant source of transmission when deciding about public health control measures.” Moreover, the inadequacy of phase I, II, and III trials to evaluate mid-term and long-term side effects from mRNA genetic vaccines may have been misleading on their suppressive impact on the innate immunity of the vaccinees.

In this paper, we call attention to three very important aspects of the safety profile of these vaccinations.

  • First is the extensively documented subversion of innate immunity, primarily via suppression of IFN-a and its associated signaling cascade. This suppression will have a wide range of consequences, not the least of which include the reactivation of latent viral infections and the reduced ability to effectively combat future infections.
  • Second is the dysregulation of the system for both preventing and detecting genetically driven malignant transformation within cells and the consequent potential for vaccination to promote those transformations.
  • Third, mRNA vaccination potentially disrupts intracellular communication carried out by exosomes, and induces cells taking up spike glycoprotein mRNA to produce high levels of spike-glycoproteincarrying exosomes, with potentially serious inflammatory consequences.

Should any of these potentials be fully realized, the impact on billions of people around the world could be enormous and could contribute to both the short-term and long-term disease burden our health care system faces.

Given the current rapidly expanding awareness of the multiple roles of G4s in regulation of mRNA translation and clearance through stress granules, the increase in pG4s due to enrichment of GC content as a consequence of codon optimization has unknown but likely far-reaching consequences. Specific analytical evaluation of the safety of these constructs in vaccines is urgently needed, including mass spectrometry for identification of cryptic expression and immunoprecipitation studies to evaluate the potential for disturbance of or interference with the essential activities of RNA and DNA binding proteins.

It is essential that further studies be conducted to determine the extent of the potential pathological consequences outlined in this paper. It is not practical for these vaccinations to be considered part of a public health campaign without a detailed analysis of the human impact of the potential collateral damage. VAERS and other monitoring systems should be optimized to detect signals related to the health consequences of mRNA vaccination we have outlined. We believe the upgraded VAERS monitoring system described in the Harvard Pilgrim Health Care, Inc. study, but unfortunately not supported by the CDC, would be a valuable start in this regard (Lazarus et al., 2010).

In the end, billions of lives are potentially at risk, given the large number of individuals injected with the SARS-CoV-2 mRNA vaccines and the broad range of adverse outcomes we have described. We call on the public health institutions to demonstrate, with evidence, why the issues discussed in this paper are not relevant to public health, or to acknowledge that they are and to act accordingly. Furthermore, we encourage all individuals to make their own health care decisions with this information as a contributing factor in those decisions.

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600X increase in fetal deaths in VAERS since mrna vaccines - April 2022

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Created by admin. Last Modification: Thursday June 9, 2022 18:51:11 GMT-0000 by admin. (Version 16)

Attached files

ID Name Comment Uploaded Size Downloads
17470 Cancer VAERS.jpg admin 21 Apr, 2022 21:33 52.89 Kb 157
17469 Neuro VAERS.jpg admin 21 Apr, 2022 21:33 27.30 Kb 142
17468 Liver VAERS.jpg admin 21 Apr, 2022 21:33 45.56 Kb 145
17467 VAERS 2021.jpg admin 21 Apr, 2022 21:32 63.57 Kb 233
17466 Innate immune suppression by SARS-CoV-2 mRNA vaccinations.pdf PDF 2022 admin 21 Apr, 2022 21:32 910.55 Kb 65
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