- Long-term Thyroid Outcomes After COVID-19 Vaccination: A Cohort Study of 2,333,496 Patients from the TriNetX Network
- VitaminDWiki - Hypothyroidism risk reduced 32 percent in those getting vitamin D levels above 50 ng – Oct 2017
- Another cause of Hypothyroidism is Hashimoto's Thyroiditis
- VitaminDWiki - Vaccination pages in VitaminDWiki 309+ studies include:
Long-term Thyroid Outcomes After COVID-19 Vaccination: A Cohort Study of 2,333,496 Patients from the TriNetX Network
Kai-Lun Cheng, Wei-Shin Yu, Yu-Hsun Wang, Gema Hernández Ibarburu, Hsiang-Lin Lee, James Cheng-Chung Wei
The Journal of Clinical Endocrinology & Metabolism, dgaf064, PDF Behind paywall
Context
Reports on long-term thyroid dysfunction following COVID-19 vaccination are limited. Understanding the risk of subacute thyroiditis, hyperthyroidism, and hypothyroidism in vaccinated individuals is crucial for post-vaccination monitoring.
Objective
This study evaluated the risk of thyroid dysfunction in COVID-19 vaccinated individuals compared to unvaccinated individuals using a large cohort.
Methods
We conducted a retrospective cohort study from January 1, 2022, to December 31, 2023, using the TriNetX database, including
- 1,166,748 vaccinated and
- 1,166,748 unvaccinated individuals.
Propensity score matching was used to balance baseline characteristics. The primary outcomes were new diagnoses of subacute thyroiditis, hyperthyroidism, and hypothyroidism.
Results
The risk of subacute thyroiditis remained unchanged (95% confidence intervals [CIs] included 1). A significant reduction in hyperthyroidism risk was observed from 3 to 9 months post-vaccination (hazard ratios [HRs]: 0.65–0.89, all 95% CIs below 1), but this trend was not significant at 12 months (HR: 0.99, 95% CI: 0.92–1.06). In contrast, the risk of hypothyroidism significantly increased from 6 to 12 months post-vaccination (HR: 1.14–1.30, all 95% CIs above 1).
Among mRNA vaccine recipients, the risk of both hyperthyroidism and hypothyroidism was significantly elevated at 12 months (HR: 1.16–2.13).
Conclusion
COVID-19 vaccination was associated with a reduced risk of hyperthyroidism and an increased risk of hypothyroidism, highlighting the need for ongoing thyroid function monitoring.
VitaminDWiki - Hypothyroidism risk reduced 32 percent in those getting vitamin D levels above 50 ng – Oct 2017
Note: Vaccinations often consume vitamin D
Another cause of Hypothyroidism is Hashimoto's Thyroiditis
which is associated with low Vitamin D, etc.
VitaminDWiki - Vaccination pages in VitaminDWiki 309+ studies include:
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- 3,600 studies found COVID Vaccination problems (REACT19) - Dec 2024
- Pfizer’s RSV vaccine found to increase risk of preterm births by 24%, etc. – Sept 2024
- US has the most vaccinations before age 1 and the most deaths - March 2024
- Benign Cancers of a portion of the brain increased 1.8 X after vaccines were available - March 2024