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COVID and vaccine spikes damage repair of adaptive immune system DNA (in the lab) - Oct 2021


SARS–CoV–2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro

by Hui Jiang 1,2,* andYa-Fang Mei 2,*
Viruses 2021, 13(10), 2056; https://doi.org/10.3390/v13102056

  • 1 Department of Molecular Biosciences, The Wenner–Gren Institute, Stockholm University, SE-10691 Stockholm, Sweden
  • 2 Department of Clinical Microbiology, Virology, Umeå University, SE-90185 Umeå, Sweden

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Severe acute respiratory syndrome coronavirus 2 (SARS–CoV–2) has led to the coronavirus disease 2019 (COVID–19) pandemic, severely affecting public health and the global economy. Adaptive immunity plays a crucial role in fighting against SARS–CoV–2 infection and directly influences the clinical outcomes of patients. Clinical studies have indicated that patients with severe COVID–19 exhibit delayed and weak adaptive immune responses; however, the mechanism by which SARS–CoV–2 impedes adaptive immunity remains unclear.

Here, by using an in vitro cell line, we report that the SARS–CoV–2 spike protein significantly inhibits DNA damage repair, which is required for effective V(D)J recombination in adaptive immunity.

Mechanistically, we found that the spike protein localizes in the nucleus and inhibits DNA damage repair by impeding key DNA repair protein BRCA1 and 53BP1 recruitment to the damage site. Our findings reveal a potential molecular mechanism by which the spike protein might impede adaptive immunity and underscore the potential side effects of full-length spike-based vaccines.
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VitaminDWiki - Observations

Previous studies found that COVID-19 infections resulted in delayed and weak adaptive immune responses
This lab study found that the COVID and Vaccine spikes are probably the source of the problem
Wonder if these spike are associated with COVID deaths and long haul


VitaminDWiki - Mortality and Virus studies


VitaminDWiki - LONG-HAUL in title (17 as of Dec 2021)

Items found: 17
Title Modified
COVID-19 long haul - meta-analysis, Vitamin D, etc. 23 Dec, 2021
Some COVID-19 infection become COVID Long-Haul - Nov 2020 15 Dec, 2021
Epstein-Barr Virus may cause Long-Haul, CFS, and MS (Vitamin D should help) 11 Dec, 2021
Epstein-Barr virus appears to cause Long-Haul and Chronic fatiure Syndrome (Vitamin D might help) 11 Dec, 2021
Long-haul after breakthrough COVID – Nov 2021 11 Dec, 2021
Long-Haul COVID is a problem even if vaccinated (Veterans)– Nov 2021 24 Nov, 2021
Long-haul, VAERS, Ivermectin, vaccines, etc. Drs. Seheult, Patrick: Video with table of contents - Sept 17, 2021 21 Sep, 2021
Your Brain on Covid-19 Long-Haul, Dr. Galland video and transcript - Aug 1, 2021 07 Aug, 2021
Long-haul COVID-19 blood tests at Mayo include vitamin D (but no results published) – July 2021 20 Jul, 2021
Most people with Long-Haul COVID-19 have low Vitamin D – July 2021 15 Jul, 2021
‘Long haul’ COVID rehab worse than cancer rehab, CDC – July 2021 13 Jul, 2021
Long-Haul COVID-19 occurred to 1 in 20 who had been asymptomatic (a study of 2 million with COVID-19) – June 2021 15 Jun, 2021
COVID-19 Long haul - excellent graph - systematic review May 26, 2021 26 May, 2021
Long-haul COVID-19 - another hint that Vitamin D should help - Dec 2020 16 Apr, 2021
Chronic Fatigue Syndrome and long-haul COVID-19 02 Apr, 2021
Probably fewer long-haul COVID-19 problems when rejuvenated immune system (Vitamin D, etc.)– Dec 2020 21 Feb, 2021
Long-haul fatigue, etc. common after viral infections (SARS1,2, MERS, Swine, 1918,...) 21 Feb, 2021



Attached files

ID Name Comment Uploaded Size Downloads
16780 Spike DNA.jpg admin 22 Dec, 2021 02:30 31.29 Kb 144
16779 SARS–CoV–2 Spike Impairs DNA Damage Repair.pdf PDF 2021 admin 22 Dec, 2021 01:38 615.17 Kb 34
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