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Flu vaccinations during pregnancy should NOT be the standard of care until tests show it is OK – Nov 2019

Influenza Vaccination of Pregnant Women and Serious Adverse Events in the Offspring.

Int J Environ Res Public Health. 2019 Nov 7;16(22). pii: E4347. doi: 10.3390/ijerph16224347.
Donzelli A1.

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Many bad results so far

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Pregnant women are increasingly considered a priority group for influenza vaccination, but the evidence in favor relies mainly on observational studies, subject to the "healthy-vaccinee bias". Propensity score methods-sometimes applied-reduce but cannot eliminate residual confounding. Meta-analyses of observational studies show relative risks far from the thresholds that would confirm the efficacy of universal vaccination for pregnant women without needing randomized controlled trials (RCTs). Critical articles have shown that in the four RCTs investigating the outcomes of this vaccination, there was a tendency towards higher offspring mortality. In the largest RCT, there was a significant excess of presumed/serious neonatal infections, and also significantly more serious adverse events. Many widely acknowledged observational results (about hormone replacing therapy, vitamin D, omega-3 fatty acids, etc.) were confuted by RCTs. Therefore the international drive to consider this vaccination a "standard of care" is not justified yet. Moreover, there is the risk of precluding further independent RCTs for "ethical considerations", so as "to not deny the benefits of influenza vaccinations to pregnant women of a control group". Instead, before promoting national campaigns for universal vaccination in pregnancy, further large, independent, and reassuring RCTs are needed, even braving challenging a current paradigm. Until then, influenza vaccination should be offered to pregnant women only once open information is available about the safety uncertainties, to allow truly informed choices, and promoting also other protective behaviors.

Created by admin. Last Modification: Saturday November 16, 2019 17:13:56 GMT-0000 by admin. (Version 5)

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12982 Flu pregnancy 2.jpg admin 16 Nov, 2019 17:05 74.74 Kb 15
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12980 Flu pregnancy.pdf PDF 2019 admin 16 Nov, 2019 17:04 312.08 Kb 5
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