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COVID while pregnant: 2.6 X more likely to be Vitamin D deficient (need to supplement) - March 2022


Serum 25(OH) Vitamin D Levels in Pregnant Women with Coronavirus Disease 2019 (COVID-19): A Case-Control Study

Int J Environ Res Public Health. 2022 Mar 26;19(7):3965. doi: 10.3390/ijerph19073965.
Nazaret Ferrer-Sánchez 1, Marina Díaz-Goicoechea 1, Victoria Mayoral-Cesar 1, Silvia García-Solbas 2, Bruno José Nievas-Soriano 3, Tesifón Parrón-Carreño 3, Ana María Fernández-Alonso 1 2

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The physiological changes during pregnancy may increase the risk of complications in pregnant women with coronavirus disease 2019 (COVID-19). Vitamin D is a fat-soluble secosteroid hormone and its role in immunity is appears to be of particular importance in this recent pandemic. Nevertheless, there is little research about the role of vitamin D levels regarding COVID-19 in pregnant women to date. This study aimed to establish a relationship between serum 25-hydroxyvitamin D (25(OH)D) levels in pregnant women and COVID-19. A comparative case-control study was performed with a study population of 256 pregnant women (82 pregnant women with infection and 174 women in control group). Serum 25(OH)D levels were significantly lower in pregnant women with COVID-19 infection than in those without infection. In addition, 89% of COVID-19-positive pregnant women had 25(OH)D deficiency, while in the control group the percentage was 75.30%, finding statistically significant differences (ORa = 2.68; 95% CI 1.19-6.06; p = 0.01). Our results find a relationship between vitamin D deficiency in pregnant women and COVID-19 infection. This finding could be relevant for actual clinical practice. Thus, more research is needed in this field.

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Unknown by this study: 1) Low D ===> Infection or 2) Infection ==> Low D

But: Many studies have found low D ==> infection
Many in VitaminDWiki and citations #24, 25 of this study

  • #24 Merzon, E.; Tworowski, D.; Gorohovski, A.; Vinker, S.; Cohen, A.G.; Green, I.; Frenkel-Morgenstern, M. Low plasma 25(OH) vitamin D level is associated with increased risk of COVID-19 infection: An Israeli population-based study. FEBS J. 2020, 287, 3693–3702.
  • #25. Katz, J.; Yue, S.; Xue, W. Increased risk for COVID-19 in patients with vitamin D deficiency. Nutrition 2021, 84, 111106.

Known: Low D increases the risk of many health problems, including those during pregnancy


VitaminDWiki - Pregnancy and Virus: 20 studies as of April 2022


Created by admin. Last Modification: Tuesday April 12, 2022 13:36:51 GMT-0000 by admin. (Version 5)

Attached files

ID Name Comment Uploaded Size Downloads
17396 COVID pregancy D.jpg admin 12 Apr, 2022 13:36 96.07 Kb 83
17394 Pregnancy COVID - lower Vitamin D.pdf PDF 2022 admin 12 Apr, 2022 13:17 571.39 Kb 43
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