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COVID vaccination makes 6X more antibodies in those having good levels of both vitamin D and Iron – June 2021


Efficacy of COVID-19 vaccine in elderly Indian population with Vitamin D and Iron deficiency

IP Journal of Nutrition, Metabolism and Health Science 2021;4(4):176-181 https://doi.org/10.18231/j.ijnmhs.2021.031
Deepika Gujjarlapudi1’ <1>, Srihita Mahavadi1, Veeraiah Namburu1, Naveed Hassan1, Nageshwar Reddy Duvvur1
<1> dr.deepikapavan at gmail.com (D. Gujjarlapudi).
1 Dept. of Biochemistry, AIG Hospitals, Hyderabad, Telangana, India

RBD Antibodies
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Antivax Antibodies
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about 5X if just Vitamin D deficient

Introduction: SARS-COV-2 is has led to a worldwide pandemic COVID-19 vaccine roll out proceeds worldwide, attention is increasingly being paid to vaccination of older people that can affect vaccine efficacy. Iron deficiency anaemia and Vitamin D deficiency is a leading global cause of years lived with disability.

Aims and Objective: To study the immune response in Vitamin D, Iron deficiency when compared to non deficient covid vaccinated recipients.

Methods: This is a hospital based observational cross-sectional study done between April 2021 to September 2021 in elderly Indian population. Total 360 vaccine recepients attending OPD post vaccination between 15-45 days were measured anti-RBD IgG antibody & anti-spike S1/S2 antibodies, vitamin D, Iron, TIBC, HB, levels in above 60 years.

Results: Out of 360 vaccine recipients, 46 had COVID-19, and we have excluded them from the study. Of the 314,They were grouped as Group I: Vitamin D deficient, Group II; Iron Deficiency, Group III :has both Deficiency of Vitamin D & Iron. GroupIV: has No Deficiency In Study I: We Compared age, sex hematological indices, vitamin D. In 314 Vaccine recipient 57.3%Male, 42.7% were female In Study II: 35% Vitamin D deficient ,30.6% Iron deficiency,23.6% had both deficiency 10.8% have no deficiency. In Study III Responses were evaluated post-vaccine RBD IgG concentration and Spike antibodies were each significantly higher among the No deficiency recipients, when compared to Iron & vitamin D Deficient recipients.

Conclusions: An integrated approach is required to better understand aging & how vaccines work in elderly which will help in improving the immune response after vaccination.

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