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COVID fought by Vitamin D as well as both mild and intense exercise - March 2022


Influence of exercise and vitamin D on the immune system against Covid-19: an integrative review of current literature

Mol Cell Biochem. 2022 Mar 8. doi: 10.1007/s11010-022-04402-7
Matheus Ribeiro Bizuti 1, Édina Starck 1, Kimberly Kamila da Silva Fagundes 1, Josiano Guilherme Puhle 2, Lucas Medeiros Lima 1, Natan Rodrigues de Oliveira 1, Guilherme Vinicio de Sousa Silva 1, Débora Tavares Resende E Silva 3

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Respiratory infections of viral origin have become the leading cause of infectious diseases in the world. In 2020, the World Health Organization (WHO) declared a pandemic due to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), Coronavirus Disease 2019 (Covid-19). The pandemic caused by the new coronavirus has challenged the entire global health system, since Covid-19 has a high rate of morbidity and mortality. The immune response to the virus depends on factors such as age, genetics, nutritional status, physical status, as well as environmental factors. Despite scientific advances, so far, there is still no specific therapy for the disease. Thus, this study aims to analyze the contribution of physical exercise and maintenance and/or supplementation of vitamin D to the strengthening of the immune system against viral infections, among them, Covid-19. Regular practice of moderate-intensity physical activity is responsible for promoting a reduction in the concentrations of pro-inflammatory cytokines (IL-6, TNF-α and IL-1β), as well as triggering the increase in the production of anti-inflammatory cytokines (IL-4 and IL-10). In addition, hypovitaminosis D predisposes to the development of chronic diseases and infections. Therefore, in patients affected by Covid-19, the maintenance of vitamin D levels contributes significantly to the 0prevention of the cytokine storm. Thus, the association between maintaining vitamin D levels and performing moderate-intensity physical exercise is responsible for strengthening the immune system and, therefore, triggering a defense mechanism against infections by intracellular microorganisms, in which SARS -CoV-2.
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References

  1. Dhama K, Khan S, Tiwari R et al (2020) Coronavirus disease 2019–COVID-19. Clin Microbiol Rev 33:e00028-e120. https://doi.org/10.1128/cmr.00028-20 - DOI - PubMed - PMC
  2. Machhi J, Herskovitz J, Senan AM et al (2020) The natural history, pathobiology, and clinical manifestations of SARS-CoV-2 infections. J Neuroimmune Pharmacol 21:1–28. https://doi.org/10.1007/s11481-020-09944-5 - DOI
  3. da Silveira MP, Fagundes KKS, Bizuti MR et al (2020) Physical exercise as a tool to help the immune system against covid-19: an integrative review of the current literature. Clin Exp Med 21:15–28. https://doi.org/10.1007/s10238-020-00650-3 - DOI - PubMed
  4. Muralidar S, Ambi SV, Sekaran S et al (2020) The emergence of COVID-19 as a global pandemic: understanding the epidemiology, immune response and potential therapeutic targets of SARS-CoV-2. Biochimie 179:85–100. https://doi.org/10.1016/j.biochi.2020.09.018 - DOI - PubMed - PMC
  5. Chandran M, Maung AC, Mithal A et al (2020) Vitamin D in COVID - 19: Dousing the fire or averting the storm?—A perspective from the Asia-Pacific. Osteoporos Sarcopenia 6:97–105. https://doi.org/10.1016/j.afos.2020.07.003 - DOI - PubMed - PMC
  6. Ali N (2020) Role of vitamin D in preventing of COVID-19 infection, progression and severity. J Infect Public Health 13:1373–1380. https://doi.org/10.1016/j.jiph.2020.06.021 - DOI - PubMed - PMC
  7. Charoenngam N, Holick MF (2020) Immunologic effects of vitamin D on human health and disease. Nutrients 12:2097. https://doi.org/10.3390/nu12072097 - DOI - PMC
  8. Marques CDL, Dantas AT, Fragoso TS et al (2010) The importance of vitamin D levels in autoimmune diseases. Braz J Rheumatol 50:67–80. https://doi.org/10.1590/S0482-50042010000100007 - DOI
  9. Yang P-H, Ding Y-B, Xu Z et al (2020) Increased circulating level of interleukin-6 and CD8+ T cell exhaustion are associated with progression of COVID-19. Infect Dis Poverty 9:161. https://doi.org/10.1186/s40249-020-00780-6 - DOI - PubMed - PMC
  10. Zumla A, Hui DS, Azhar EI et al (2020) Reducing mortality from 2019-nCoV: host-directed therapies should be an option. Lancet 395:e35–e36. https://doi.org/10.1016/S0140-6736(20)30305-6 - DOI - PubMed - PMC
  11. Sousa FH, Casanova V, Findlay F et al (2017) Cathelicidins display conserved direct antiviral activity towards rhinovirus. Peptides 95:76–83. https://doi.org/10.1016/j.peptides.2017.07.013 - DOI - PubMed - PMC
  12. Barlow PG, Svoboda P, Mackellar A et al (2011) Antiviral activity and increased host defense against influenza infection elicited by the human cathelicidin LL-37. PLoS ONE 6:e25333. https://doi.org/10.1371/journal.pone.0025333 - DOI - PubMed - PMC
  13. Tripathi S, Tecle T, Verma A et al (2013) The human cathelicidin LL-37 inhibits influenza A viruses through a mechanism distinct from that of surfactant protein D or defensins. J Gen Virol 94:40–49. https://doi.org/10.1099/vir.0.045013-0 - DOI - PubMed - PMC
  14. Rawson ES, Miles MP, Larson-Meyer DE (2018) Dietary supplements for health, adaptation, and recovery in athletes. Int J Sport Nutr Exerc Metab 28:188–199. https://doi.org/10.1123/ijsnem.2017-0340 - DOI - PubMed
  15. He CS, Fraser WD, Tang J et al (2016) The effect of 14 weeks of vitamin D 3 supplementation on antimicrobial peptides and proteins in athletes. J Sports Sci 34:67–74. https://doi.org/10.1080/02640414.2015.1033642 - DOI - PubMed
  16. Pastuszak-Lewandoska D, Domańska-Senderowska D, Kiszałkiewicz J et al (2020) Expression levels of selected cytokines and microRNAs in response to vitamin D supplementation in ultra-marathon runners. Eur J Sport Sci 20:219–228. https://doi.org/10.1080/17461391.2019.1635649 - DOI - PubMed
  17. Terra R, da Silva SAG, Pinto VS et al (2012) Effect of exercise on immune system: response, adaptation and cell signaling. Revista Brasileira de Medicina do Esporte 18:208–214. https://doi.org/10.1590/S1517-86922012000300015 - DOI
  18. El-kader SMA, Al-Shreef FM (2018) Inflammatory cytokines and immune system modulation by aerobic versus resisted exercise training for elderly. Afr Health Sci 18:120–131. https://doi.org/10.4314/ahs.v18i1.16 - DOI
  19. Paolucci EM, Loukov D, Bowdish DME et al (2018) exercise reduces depression and inflammation but intensity matters. Biol Psychol 133:79–84. https://doi.org/10.1016/j.biopsycho.2018.01.015 - DOI - PubMed
  20. Ferreira GA, Felippe LC, Bertuzzi R et al (2018) The effects of acute and chronic sprint-interval training on cytokine responses are independent of prior caffeine intake. Front Physiol 9:671. https://doi.org/10.3389/fphys.2018.00671 - DOI - PubMed - PMC
  21. Senna SM, Torres MK, Lopes DA et al (2016) Moderate physical training attenuates perinatal low-protein-induced spleen lymphocyte apoptosis in endotoxemic adult offspring rats. Eur J Nutr 55:1113–1122. https://doi.org/10.1007/s00394-015-0925-y - DOI - PubMed
  22. Bigley AB, Rezvani K, Pistillo M et al (2015) Acute exercise preferentially redeploys NK-cells with a highly differentiated phenotype and augments cytotoxicity against lymphoma and multiple myeloma target cells. Part II: impact of latent cytomegalovirus infection and catecholamine sensitivity. Brain Behav Immun 49:59–65. https://doi.org/10.1016/j.bbi.2014.12.027 - DOI - PubMed
  23. Sellami M, Gasmi M, Denham J et al (2018) Effects of acute and chronic exercise on immunological parameters in the elderly aged: can physical activity counteract the effects of aging? Front Immunol 9:2187. https://doi.org/10.3389/fimmu.2018.02187 - DOI - PubMed - PMC
  24. Simpson RJ, Kunz H, Agha N et al (2015) exercise and the regulation of immune functions. Prog Mol Biol Transl Sci 135:355–379. https://doi.org/10.1016/bs.pmbts.2015.08.001 - DOI - PubMed
  25. Leandro CG, Silva WTF, Lima-Silva AE (2020) Covid-19 and exercise-induced immunomodulation. NeuroImmunoModulation 27:75–78. https://doi.org/10.1159/000508951 - DOI - PubMed
  26. Jamilloux Y, Gerfaud-Valentin M, Sève P (2020) Intravenous anakinra for cytokine storm syndromes. Lancet Rheumatol 2:E521–E522. https://doi.org/10.1016/S2665-9913(20)30225-3 - DOI - PubMed - PMC
  27. Mehta P, Porter JC, Manson JJ et al (2020) Therapeutic blockade of granulocyte macrophage colony-stimulating factor in COVID-19-associated hyperinflammation: challenges and opportunities. Lancet Respir Med 8:822–830. https://doi.org/10.1016/S2213-2600(20)30267-8 - DOI - PubMed - PMC
  28. Svensson M, Lexell J, Deierborg T (2015) Effects of physical exercise on neuroinflammation, neuroplasticity, neurodegeneration, and behavior. Neurorehabil Neural Repair 29:577–589. https://doi.org/10.1177/1545968314562108 - DOI - PubMed
  29. Steensberg A, Fischer CP, Keller C et al (2003) IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans. Am J Physiol Metab 285:E433–E437. https://doi.org/10.1152/ajpendo.00074.2003 - DOI
  30. Scheffer DL, Latini A (2020) exercise-induced immune system response: anti-inflammatory status on peripheral and central organs. Biochim Biophys Acta Mol Basis Dis 1866:165823. https://doi.org/10.1016/j.bbadis.2020.165823 - DOI - PubMed - PMC
  31. Fischer CP (2006) Interleukin-6 in acute exercise and training: what is the biological relevance? Exerc Immunol Rev 12:6–33 - PubMed
  32. Wedell-Neergaard AS, Lang Lehrskov L, Christensen RH et al (2019) exercise-induced changes in visceral adipose tissue mass are regulated by IL-6 signaling: a randomized controlled trial. Cell Metab 29:844–855. https://doi.org/10.1016/j.cmet.2018.12.007 - DOI - PubMed
  33. Pedersen BK (2017) Anti-inflammatory effects of exercise: role in diabetes and cardiovascular disease. Eur J Clin Investig 47:600–611. https://doi.org/10.1111/eci.12781 - DOI
  34. Kamen DL, Tangpricha V (2010) Vitamin D and molecular actions on the immune system: modulation of innate and autoimmunity. J Mol Med 88:441–450. https://doi.org/10.1007/s00109-010-0590-9 - DOI - PubMed
  35. White JH (2012) Vitamin D metabolism and signaling in the immune system. Rev Endocr Metab Disord 13:21–29. https://doi.org/10.1007/s11154-011-9195-z - DOI - PubMed
  36. Martineau AR, Jolliffe DA, Hooper RL et al (2017) Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ 356:i6583. https://doi.org/10.1136/bmj.i6583 - DOI - PubMed - PMC
  37. Gonçalves TJM, Gonçalves SEAB, Guarnieri A et al (2020) Prevalence of obesity and hypovitaminosis D in elderly with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Clin Nutr ESPEN 40:110–114. https://doi.org/10.1016/j.clnesp.2020.10.008 - DOI - PubMed - PMC
  38. Laird E, Rhodes J, Kenny RA (2020) Vitamin D and inflammation: potential implications for severity of Covid-19. Ir Med J 113:81 - PubMed
  39. Merzon E, Tworowski D, Gorohovski A et al (2020) Low plasma 25 (OH) vitamin D level is associated with increased risk of COVID-19 infection: an Israeli population-based study. FEBS J 287:3693–3702. https://doi.org/10.1111/febs.15495 - DOI - PubMed
  40. Liu PT, Stenger S, Li H et al (2006) Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science 311:1773–1783. https://doi.org/10.1126/science.1123933 - DOI
  41. Xu J, Yang J, Chen J et al (2017) Vitamin D alleviates lipopolysaccharide-induced acute lung injury via regulation of the renin-angiotensin system. Mol Med Rep 2017:7432–7438. https://doi.org/10.3892/mmr.2017.7546 - DOI
  42. Bae M, Kim H (2020) The role of Vitamin C, Vitamin D, and selenium in immune system against COVID-19. Molecules 25:5346. https://doi.org/10.3390/moléculas25225346 - DOI - PubMed - PMC
  43. Campbell PA, Young MW, Lee RC (2020) Vitamin D clinical pharmacology: relevance to COVID-19 pathogenesis. J Natl Med Assoc. https://doi.org/10.1016/j.jnma.2020.09.152 - DOI - PubMed
  44. Mora RJ, Iwata M, von Andrian UH (2008) Vitamin effects on the immune system: vitamins A and D take centre stage. Nat Rev Immunol 8:685–698. https://doi.org/10.1038/nri2378 - DOI - PubMed - PMC
  45. Prietl B, Treiber G, Pieber T et al (2013) Vitamin D and immune function. Nutrients 5:2502–2521. https://doi.org/10.3390/nu5072502 - DOI - PubMed - PMC
  46. Kumar R, Rathi H, Haq A et al (2021) Putative roles of vitamin D in modulating immune response and immunopathology associated with COVID-19. Virus Res 292:198235. https://doi.org/10.1016/j.virusres.2020.198235 - DOI - PubMed
  47. Cantorna MT, Snyder L, Lin YD et al (2015) Vitamin D and 1,25(OH)2D regulation of T cells. Nutrients 7:3011–3021. https://doi.org/10.3390/nu7043011 - DOI - PubMed - PMC
  48. Chatterjee S, Sengupta T, Majumder S et al (2020) COVID-19: a probable role of the anticoagulant Protein S in managing COVID-19-associated coagulopathy. Aging 12:15954–15961. https://doi.org/10.18632/aging.103869 - DOI - PubMed - PMC
  49. Ali MAM, Spinler AS (2021) COVID-19 and thrombosis: from bench to bedside. Trends Cardiovasc Med 31:143–160. https://doi.org/10.1016/j.tcm.2020.12.004 - DOI - PubMed
  50. Sengupta T, Majumder R, Majumder S (2021) Role of vitamin D in treating COVID-19-associated coagulopathy: problems and perspectives. Mol Cell Biochem 476:2421–2427. https://doi.org/10.1007/s11010-021-04093-6 - DOI - PubMed - PMC
  51. Meehan M, Penckofer S (2014) The role of vitamin D in the aging adult. J Aging Gerontol 2:60–71. https://doi.org/10.12974/2309-6128.2014.02.02.1 - DOI - PubMed - PMC
  52. Abraham J, Dowling K, Florentine S (2021) Can optimum solar radiation exposure or supplemented vitamin D intake reduce the severity of COVID-19 symptoms? Int J Environ Res Public Health 18:740. https://doi.org/10.3390/ijerph18020740 - DOI - PMC
  53. Bilezikian JP, Bikle D, Hewison M et al (2020) Mechanisms in endocrinology: vitamin D and COVID-19. Eur J Endocrinol 183:R133–R147. https://doi.org/10.1530/EJE-20-0665 - DOI - PubMed
  54. Machado PRL, Araújo MLAB, Carvalho L et al (2004) Mecanismos de resposta imune às infecções. An Bras Dermatol 79:647–662. https://doi.org/10.1590/S0365-05962004000600002 - DOI
  55. Aranow C (2011) Vitamin D and the immune system. J Investig Med 59:881–886. https://doi.org/10.2310/JIM.0b013e31821b8755 - DOI - PubMed - PMC
  56. Adams JS, Ren S, Liu PT et al (2009) Vitamin D-directed rheostatic regulation of monocyte antibacterial responses. J Immunol 182:4289–4295. https://doi.org/10.4049/jimmunol.0803736 - DOI - PubMed
  57. Charoenngam N, Shirvani A, Holick MF (2021) Vitamin D and Its Potential Benefit for the COVID-19 Pandemic. Endocr Pract 27:484–493. https://doi.org/10.1016/j.eprac.2021.03.006 - DOI - PubMed - PMC
  58. Uberti F, Lattuada D, Morsanuto V et al (2014) Vitamin D protects human endothelial cells from oxidative stress through the autophagic and survival pathways. J Clin Endocrinol Metab 99:1367–1374. https://doi.org/10.1210/jc.2013-2103 - DOI - PubMed
  59. Todd JJ, McSorley EM, Madigan SM et al (2017) Oral spray wintertime vitamin D 3 supplementation has no impact on inflammation in Gaelic footballers. Scand J Med Sci Sports 27:1300–1307. https://doi.org/10.1111/sms.12785 - DOI - PubMed
  60. Banchereau J, Steinman RM (1998) Dendritic cells and the control of immunity. Nature 392:245–252. https://doi.org/10.1038/32588 - DOI
  61. Dickie LJ, Church LD, Coulthard LR et al (2010) Vitamin D3 down-regulates intracellular Toll-like receptor 9 expression and Toll-like receptor 9-induced IL-6 production in human monocytes. Rheumatology 49:1466–1471. https://doi.org/10.1093/rheumatology/keq124 - DOI - PubMed
  62. Jevalikar G, Mithal A, Singh A et al (2021) Lack of association of baseline 25-hydroxyvitamin D levels with disease severity and mortality in Indian patients hospitalized for COVID-19. Sci Rep 11:6258. https://doi.org/10.1038/s41598-021-85809-y - DOI - PubMed - PMC
  63. Güven M, Gültekin H (2021) The effect of high-dose parenteral vitamin D3 on COVID-19-related inhospital mortality in critical COVID-19 patients during intensive care unit admission: an observational cohort study. Eur J Clin Nutr. https://doi.org/10.1038/s41430-021-00984-5 - DOI - PubMed - PMC
  64. Jain A, Chaurasia R, Sengar NS et al (2020) Analysis of vitamin D level among asymptomatic and critically ill COVID-19 patients and its correlation with inflammatory markers. Sci Rep 10:20191. https://doi.org/10.1038/s41598-020-77093-z - DOI - PubMed - PMC
  65. Bobart LF, Dietrich MA, Johannsen N et al (2017) Emerging relationships between vitamin D status, physical activity habits, and immune indices in college-aged females. Int J Vitam Nutr Res 87:49–58. https://doi.org/10.1024/0300-9831/a000424 - DOI
  66. Mercola J, Grant WB, Wagner CL (2020) Evidence regarding vitamin D and risk of COVID-19 and its severity. Nutrients 12:3361. https://doi.org/10.3390/nu12113361 - DOI - PMC
  67. Grant WB, Lahore H, Rockwell MS (2020) The benefits of vitamin D supplementation for athletes: better performance and reduced risk of COVID-19. Nutrients 12:3741. https://doi.org/10.3390/nu12123741 - DOI - PMC
  68. Yang YC, Chou CL, Kao CL (2020) exercise, nutrition, and medication considerations in the light of the COVID pandemic, with specific focus on geriatric population: a literature review. J Chin Med Assoc 83:977–980. https://doi.org/10.1097/JCMA.0000000000000393 - DOI - PubMed - PMC

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