Toggle Health Problems and D

Hypothesis: Magnesium might prevent and treat Chronic Kidney Disease – April 2018

Renal Replacement Therapy (2018) 4:1 DOI 10.1186/s41100-017-0142-7
Ryota Ikee


Update: The emerging role of magnesium in CKD- Jan 2022  PDF

Magnesium and Vitamin D category contains the following summary

349 items in category, see also

Mg and Vitamin D

Dr. Dean

Number of studies in both of the categories of Magnesium and:

Bone 15,  Cardiovascular 17,   Diabetes 27. Depression 14,  Obesity 11,   Omega-3 35,  Zinc 23,  Pregnancy 10,  Headache 11,   Virus 26,   Calcium 26   Virus 26   Mortality 9   Hypertension 11   Inflammation 3   Pain 7 etc.

 Download the PDF from VitaminDWiki

Magnesium (Mg) is an essential element that plays pivotal roles in a number of biological processes in the human body. Hypomagnesemia is involved in the pathophysiology of hypertension, vascular calcification, and metabolic derangements including diabetes mellitus and dyslipidemia, which are all risk factors for cardiovascular disease, the leading cause of mortality and morbidity in patients with chronic kidney disease (CKD).
Hypomagnesemia is also associated with the development and progression of CKD. As CKD advances, renal Mg excretion decreases and hypermagnesemia emerges in end-stage renal disease (ESRD). In addition, dialysates with high Mg concentrations, which were used in the early era of dialysis therapy, increased the risk of hypermagnesemia, and thus, the dialysate Mg composition has since been reduced. Accordingly, dialysis patients in the modern era commonly have normomagnesemia or even hypomagnesemia.

The relationships between hypomagnesemia and cardiovascular disease and mortality have been increasingly reported in observational studies in CKD/ESRD. However, these relationships may be attenuated by a patient's race or region.

Although dialysates with higher Mg concentrations or Mg-containing phosphate binders appear to be promising in this setting, only a few interventional studies have examined the effects of Mg supplementation on cardiovascular lesions. Furthermore, the effects of Mg supplementation on mortality have not yet been investigated as a primary end-point in randomized controlled trials. Further studies are required in order to establish the efficacy and safety of Mg in CKD patients.

Created by admin. Last Modification: Thursday August 4, 2022 13:19:02 GMT-0000 by admin. (Version 4)

Attached files

ID Name Comment Uploaded Size Downloads
18242 Mg CKD.pdf admin 04 Aug, 2022 399.86 Kb 112
10515 Chronic Kidney Magnesium.pdf admin 09 Sep, 2018 433.98 Kb 678