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7100 IU (50000 weekly) restored vitamin D levels for those with Chronic Kidney Disease – July 2012

Cholecalciferol Supplementation in Chronic Kidney Disease: Restoration of Vitamin D Status and Impact on Parathyroid Hormone

Ann Nutr Metab 2012;61:74-82 (DOI: 10.1159/000339618)
Miriam G. Garcia-Lopesa, Roberta Pillarb, Maria Ayako Kamimuraa, b, Lillian A. Rochab, Maria Eugênia F. Canzianib, Aluízio B. Carvalhob, Lilian Cupparia, b
A Nutrition Program and
B Division of Nephrology, Federal University of São Paulo, São Paulo, Brazil

Background/Aims: Hypovitaminosis D is highly prevalent among patients with chronic kidney disease (CKD) and has been associated with poor outcome. We aimed to test the effect of a protocol of cholecalciferol supplementation on the restoration of vitamin D status and on parathyroid hormone (PTH) levels in patients with CKD.

Methods: This was a prospective interventional study of 6 months. Forty-five CKD patients (stages 3 and 4) with 25-hydroxyvitamin D deficiency [25(OH)D <15 ng/ml] were included. Patients received a weekly dose of 50,000 IU of cholecalciferol during 3 months, and 50,000 IU/month thereafter for those who had achieved 25(OH)D ?30 ng/ml.

Results: At 3 months, 78% of the patients restored their vitamin D status. At 6 months, only 43% of those patients maintained adequate vitamin D status. PTH decreased at 3 months (p = 0.02) but returned to baseline levels after 6 months. Fibroblast growth factor 23 increased at 3 months (p = 0.001) and returned to initial levels at 6 months. No changes were found in serum 1,25(OH)2D, ionized calcium and phosphorus.

Conclusions: A weekly dose of 50,000 IU of cholecalciferol for 3 months restored the vitamin D status of most patients and led to a reduction in PTH. The monthly dose of 50,000 IU appears not to be sufficient to maintain the levels of 25(OH)D.

Copyright © 2012 S. Karger AG, Basel

Lilian Cuppari, Department of Medicine, Division of Nephrology
Federal University of São Paulo, Rua Pedro de Toledo 282
São Paulo, SP 04039-000 (Brazil), Tel. +55 11 5904 8499, E-Mail lcuppari at uol.com.br

Received: November 14, 2011, Accepted after revision: May 21, 2012, Published online: August 7, 2012

See also VitaminDWiki