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Low Magnesium associated with severe COVID – many studies

Can Maintaining Optimal Magnesium Balance Reduce the Disease Severity of COVID-19 Patients? –March 2022

Front. Endocrinol. 13:843152. doi: 10.3389/fendo.2022.843152
Mark Eskander and Mohammed S. Razzaque
Department of Pathology, Lake Erie College of Osteopathic Medicine, Erie, PA, United States

The coronavirus disease (COVID-19) caught the world by surprise, claiming millions of lives due to its deadly effects. Ongoing research studies evaluate the measures that can reduce the severity of symptoms in patients infected by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Magnesium is an essential nutrient that has many studied benefits in humans. This brief commentary aims to describe the potential benefits of magnesium on COVID-19 patients and the reported effects of low versus high magnesium levels in SARS-CoV-2 infected individuals. Also, the potential benefits of vitamin D and how magnesium acts as a cofactor to activate vitamin D functions are elaborated. The results of the existing studies point towards evidence that magnesium may have significant benefits in reducing the severity of COVID-19 symptoms. There is also evidence that magnesium-dependent vitamin D activities may have antiviral effects, thus potentially being able to reduce rates of COVID-19 infection, which is a hypothesis that should be further tested.

The COVID-19 primarily causes respiratory distress but has a broad range of other clinical manifestations and affects various organs and systems in the body. COVID-19 is especially lethal to elderly populations at higher risk (1,2). As of September 3rd, 2021, the current worldwide death rate of individuals infected by COVID-19 is 4,539,723 (World Health Organization). Many public health measures have already been taken to try to prevent the spread of COVID-19, such as face mask mandates, vaccine inoculation, quarantine, social distancing, limited capacities at public venues, and a shift to online work. However, COVID-19 is still proving to be a health concern as cases of infection continue to rise. The continued infection of individuals by COVID-19 may be due to the high transmissibility of the virus (3-6). It is also proposed that some of the new variants of the virus are even more rapidly transmissible and lethal. Thus, certain preventative measures are essential to find to reduce the severity of symptoms and improve patient outcomes in individuals that have been infected, since the prevention of infection is not always possible.

Basic nutrients that optimize physiologic functions in the body, such as magnesium, maybe used as a prophylactic measure that can improve patient outcomes in individuals infected by SARS-CoV-2, and potentially even reduce the intensity of the infection by the virus by potentiating vitamin D functions. In the U.S., more than 50% of people are magnesium deficient (7, 8), and magnesium deficiency is also prevalent in many other countries. The low level of magnesium in the general population may make individuals more vulnerable to viral insults. The high prevalence of magnesium deficiency makes it important to determine how optimal and suboptimal magnesium levels affect COVID-19 patient outcomes, which this paper aims to elaborate on.
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Misc Magnesium and COVID articles

VitaminDWiki - 24 studies in both categories Virus and Magnesium

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Number of studies in both of the categories of Magnesium and:

Bone 15,  Cardiovascular 17,   Diabetes 25. Depression 14,  Obesity 11,   Omega-3 30,  Zinc 21,  Pregnancy 10,  Headache 10,   Virus 24,   Calcium 24   Virus 24   Mortality 7   Hypertension 11   Inflammation 3   Pain 7 etc.

Created by admin. Last Modification: Saturday November 19, 2022 11:28:19 GMT-0000 by admin. (Version 9)

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18835 Mg COVID letter to editor.pdf admin 19 Nov, 2022 11:26 265.77 Kb 9
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18740 COVID is more severe if low Magnesium_CompressPdf.pdf PDF 2022 admin 29 Oct, 2022 00:43 145.62 Kb 23
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