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Large vessel Ischemic Stroke 13 X more likely if low vitamin D – Nov 2017


Vitamin D Status in Small Vessel and Large Vessel Ischemic Stroke Patients: A Case-control Study.

Adv Biomed Res. 2017 Nov 30;6:146. doi: 10.4103/2277-9175.219411
Manouchehri N1,2, Vakil-Asadollahi M1, Zandifar A1, Rasmani F3, Saadatnia M2,3.
1 Medical Students' Research Center, School of Medicine, Isfahan U. of Medical Sciences, Isfahan, Iran.
2 Isfahan Neurosciences Research Center, Alzahra Hospital, Isfahan U. of Medical Sciences, Isfahan, Iran.
3 Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.

BACKGROUND:
Vitamin D insufficiency is a globally widespread issue. Recent studies have reported a high prevalence of Vitamin D deficiency in Middle-East countries. Studies have shown negative effects of Vitamin D deficiency on endothelium and related diseases such as ischemic brain stroke. Here, we assessed Vitamin D status in patients with different types of ischemic brain stroke and control group.

MATERIALS AND METHODS:
Seventy-five patients (49.3% small vessel, 50.7% large vessel) and 75 controls, matched for age (68.01 ± 10.94 vs. 67.64 ± 10.24) and sex (42 male and 33 female) were recruited. 25(OH) D levels were measured by Chemiluminescence immunoassay. 25(OH) D status was considered as severely, moderately, or mildly deficient and normal with 25(OH) D levels of less than 5, 5-10, 10-16, and >16 ng/ml, respectively.

RESULTS:
Mean ± standard error concentration of 25(OH) D in cases and controls were 17.7 ± 1.5 and 26.9 ± 1.6 (P = 0.0001), respectively. Mild, moderate, and severe Vitamin D deficiency were observed in 10.8%, 32.4%, 8.1% vs. 34.3%, 31.5%, 9.5% of small vessel and large vessel group, respectively. 21.7% of the controls were Vitamin D deficient.
Vitamin D deficiency was significantly associated with higher risk for ischemic stroke, (P = 0.000, OR = 7.17, 95% confidence interval: 3.36-15.29).
s25(OH) D levels were significantly higher in control group comparing to small vessel (26.9 ± 1.6 vs. 20.59 ± 2.6 P < 0.05) and large vessel (26.9 ± 1.6 vs. 13.4 ± 1.3 P < 0.001) stroke patients. Small vessel group had significantly higher levels of Vitamin D than large vessel (P < 0.05).

CONCLUSION:
Vitamin D deficiency significantly increases the risk of ischemic stroke, favoring the types with the pathogenesis of large vessel strokes.
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Large Vessels

Large vessles are those > 0.1 mm
2/3 of symptomatic strokes are in large vessels
Large vessel strokes have almost 3X the death rate as small vessel strokes
Image


VitaminDWiki – Stroke category contains

122 items in stroke category - see also Overview Stroke and vitamin D,
Overview Hypertension and Vitamin D  Overview Cardiovascular and vitamin D

Stroke more likely if low Vitamin D

Post-Stroke worse if low Vitamin D

Post-Stroke better if add Vitamin D

Post-Stroke better if Vitamin D actually gets to cells

9 studies in both categories Depression and Stroke

Stroke Meta-analysis


23+ VitaminDWiki Stroke pages have ISCHEMIC OR ISCHAEMIC in the title

This list is automatically updated

Items found: 23
Title Modified
Ischemic Stroke is 18% more likely if poor Vitamin D genes (unless take more Vitamin D) – Feb 2024 21 Mar, 2024
High Omega-3 reduced risk of Ischemic stroke by 18% - Dec 2023 05 Jan, 2024
Elderly vaccinated for COVID were 2X more likely to die of ischemic stroke (2930 vs 1180 deaths)– Nov 2021 22 Nov, 2021
Ischaemic stroke – Vitamin D doubled survival (Injection followed by monthly 60,000 IU) – RCT Aug 2016 05 Mar, 2021
Poor Ischemic stroke outcome (END) 2.6 X worse if low vitamin D – March 2019 26 Nov, 2019
Death after Ischemic Stroke 2.5 X more likely if less than 10 ng of Vitamin D – May 2019 02 May, 2019
Improved recovery from ischemic stroke with Vitamin D (300,000 IU injection) – RCT June 2018 29 Jun, 2018
Ischemic Stroke risk reduced by 2.5 if have good level of vitamin D – meta-analysis Feb 2018 28 Feb, 2018
Ischaemic Stroke has less impact in animals supplemented with Omega-3 – Jan 2018 13 Feb, 2018
Vitamin D levels drop after ischemic stroke – Dec 2017 20 Jan, 2018
Ischemic stroke 17 X more likely if low vitamin D – April 2017 13 Jan, 2018
Large vessel Ischemic Stroke 13 X more likely if low vitamin D – Nov 2017 04 Jan, 2018
Intracranial arterial calcification in 85 percent of ischemic strokes (Vitamin K and Vitamin D should help) – Oct 2017 27 Oct, 2017
Ischemic stroke and low vitamin D – 3X higher risk of poor outcome, 6 X higher risk of a second stroke, Oct 2017 04 Oct, 2017
Better outcome following Ischemic stroke if injected with 600,000 IU of vitamin D – RCT Feb 2017 01 Aug, 2017
Death within 2 years of surviving an ischemic stroke 10X less likely if high vitamin D – July 2017 01 Aug, 2017
Risk of Ischemic Stroke doubles if take more than 1 gram of Calcium daily for years – May 2017 20 May, 2017
Ischemic Stroke risk best predicted by Vitamin D, including PTH improves the prediction – Feb 2017 02 Mar, 2017
Ischemic Stroke with low vitamin D resulted in larger lesions – May 2015 11 Mar, 2016
Vitamin D associated with 50 percent less ischemic stroke – meta-analysis Aug 2012 12 Jul, 2015
Ischemic Stroke 3X more likely if Vitamin D Receptor gene change (Fok 1) – Jan 2014 29 Dec, 2014
Ischemic stroke 2X more likely if Vitamin D Receptor gene problem – Dec 2014 17 Dec, 2014
Acute ischemic stroke 19 percent more likely if even lower vitamin D – Sept 2013 14 Sep, 2013

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Created by admin. Last Modification: Thursday March 21, 2024 12:17:10 GMT-0000 by admin. (Version 7)

Attached files

ID Name Comment Uploaded Size Downloads
9121 Stroke large - small.jpg admin 04 Jan, 2018 42.60 Kb 5016
9064 Ischemic Stroke.pdf admin 30 Dec, 2017 357.32 Kb 713