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Low vitamin D at time of stroke predicts 3 X more likely to die in a month (unless add Vit D) – Dec 2017


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Serum levels of 25-hydroxyvitamin D predicts infarct volume and mortality in ischemic stroke patients Dec 2017

J Neuroimmunol. 2017 Dec 15;313:41-45. doi: 10.1016/j.jneuroim.2017.10.002. Epub 2017 Oct 5.

Low Vitamin D (Q1) predicts far more likely to die
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Nie Z1, Ji XC2, Wang J3, Zhang HX4.

  • 1 Department of Radiology,The First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China. Electronic address: nieyisheng at 163.com.
  • 2 EEG Room,The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China.
  • 3 Department of Radiology,The First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China.
  • 4 Department of Spinal Surgery,Henan, Luoyang Bone-Setting Hospital, Luoyang, China.

BACKGROUND:
The aim of this study is to determine 25-hydroxyvitamin D [25(OH) D] levels in serum, and investigate their associations with cardiovascular disease (CVD) or all-cause mortality in a 1-year follow-up study in patients with first-ever ischemic stroke.

METHODS:
From November 2013 to October 2015, 387 consecutive patients with ischemic stroke admitted to our hospital were identified. Serum 25(OH) D levels were measured at admission. Infarct volume was measured using diffusion-weighted imaging (DWI). The primary end point was CVD mortality among 1year. The secondary end point was all-cause mortality.

RESULTS:
In this study, 387 patients were included. A statistically significant negative correlation between serum 25(OH) D level and infarct volume was found (r=-0.442; P<0.001). There were 74 patients (19.1%, 95%CI: 15.2%-23.0%) died, including 36 CVD mortality (9.3%, 95CI%: 6.4%-12.2%). The mortality distribution across the 25(OH) D quartiles ranged between 39.2% (first quartile) to 5.2% (fourth quartile) for all-cause mortality and between 18.6% (first quartile) to 2.1% (fourth quartile) for CVD mortality. In a multivariate model using the first quartiles of 25(OH) D vs. quartiles 2 through 4 together with the clinical variables, the marker displayed prognostic information CVD mortality: OR for first quartile, 3.06 [95% CI, 2.16-4.95]; all-cause mortality: OR for first quartile, 2.76 [95% CI, 2.01-4.32].

CONCLUSIONS:
The data show serum levels of 25(OH) D at admission is useful prognostic marker of CVD and all-cause mortality in Chinese patients with ischemic stroke.

PMID: 29153607 DOI: 10.1016/j.jneuroim.2017.10.002


3.9 X more likely to die of stroke if low Vitamin D - Feb 2018

Vitamin D deficiency in relation to the poor functional outcomes in nondiabetic patients with ischemic stroke.
Biosci Rep. 2018 Feb 5. pii: BSR20171509. doi: 10.1042/BSR20171509.
Wei ZN1, Kuang JG2.

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Objective To assess the hypothesis that vitamin D, reflected by 25-hydroxyvitamin D [25(OH)D] would be associated with higher risk of poor functional outcomes among nondiabetic stroke patients.

Methods This study was conducted in Nanchang, China. Serum concentration of 25(OH) D and NIH stroke scale (NIHSS) were measured at the time of admission. Functional outcome was measured by modified Rankin scale (mRS) at 1 year after admission. Multivariate analyses were performed using logistic regression models. The cut point of 25(OH) D level for vitamin D deficiency was 20ng/ml.

Results In this study, 266 nondiabetic subjects with stroke were included. One hundred and forty-nine out of the 266 patients were defined as vitamin D deficiency (56%). The poor outcome distribution across the 25(OH) D quartiles ranged between 64% (first quartile) to 13% (fourth quartile). In those 149 patients with vitamin D deficiency, 75 patients were defined as poor functional outcomes, giving a prevalence rate of 50% (95% confidence intervalCI: 42%-58%). In multivariate analysis models, for vitamin D deficiency, the adjusted risk of poor functional outcomes and mortality increased by 220% (odds ratios [OR]: 3.2; 95% CI, 1.7-4.2, P<0.001) and 290% (OR: 3.9; 95% CI, 2.1-5.8, P<0.001), respectively.

Conclusions Vitamin D deficiency is associated with an increased risk of poor functional outcome events in Chinese nondiabetic stroke individuals.

PMID: 29437901 DOI: 10.1042/BSR20171509


Created by admin. Last Modification: Wednesday December 12, 2018 14:19:58 GMT-0000 by admin. (Version 14)

Attached files

ID Name Comment Uploaded Size Downloads
9348 Survive stroke.jpg admin 14 Feb, 2018 24.73 Kb 626
9347 Stroke Feb 2018.pdf admin 14 Feb, 2018 586.60 Kb 926
8792 Stroke mortality.jpg admin 21 Nov, 2017 15.25 Kb 677