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Vitamin D associated with 50 percent less ischemic stroke – meta-analysis Aug 2012

25-Hydroxyvitamin D and symptomatic ischemic stroke: An Original Study and Meta-Analysis - 2012

Ann Neurol. 2012 Aug 25. doi: 10.1002/ana.23738.
Brøndum-Jacobsen P, Nordestgaard BG, Schnohr P, Benn M.
Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital; Faculty of Health and Medical Sciences, University of Copenhagen.

OBJECTIVE: We tested the hypothesis that low plasma concentrations of 25-hydroxyvitamin D are associated with increased risk of symptomatic ischemic stroke in the general population.

METHODS: We measured plasma 25-hydroxyvitamin D in 10,170 individuals from the general population, the Copenhagen City Heart Study.
During 21 years of follow-up, 1,256 and 164 persons developed ischemic and hemorrhagic stroke, respectively.
In a meta-analysis of ischemic stroke, we included 10 studies, 58,384 participants, and 2,644 events.

RESULTS: Stepwise decreasing plasma 25-hydroxyvitamin D concentrations were associated with stepwise increasing risk of ischemic stroke both as a function of seasonally adjusted percentile categories and as a function of clinical categories of 25-hydroxyvitamin D (p for trend ≤ 2 × 10(-3) ). In a Cox regression model comparing individuals with plasma 25-hydroxyvitamin D concentrations between the 1st and 4th percentiles to individuals with 25-hydroxyvitamin D concentrations between the 50th and 100th percentiles, multivariate adjusted hazard ratio of ischemic stroke was 1.82 (95% confidence interval, 1.41-2.34).

Comparing individuals with clinical categories of severe vitamin D deficiency (<25.0nmol/l [<10.0ng/ml]) to individuals with optimal vitamin D status (≥75.0nmol/l [≥30.0ng/ml]), the multivariate adjusted hazard ratio of ischemic stroke was 1.36 (1.09-1.70). 25-Hydroxyvitamin D concentrations were not associated with risk of hemorrhagic stroke.

In a meta-analysis comparing lowest versus highest quartile of 25-hydroxyvitamin D concentrations, the multivariate adjusted odds ratio of ischemic stroke was 1.54 (1.43-1.65) with a corresponding hazard ratio of 1.46 (1.35-1.58) in prospective general population studies.

INTERPRETATION: In this large population-based prospective study, we observed stepwise increasing risk of symptomatic ischemic stroke with decreasing plasma 25-hydroxyvitamin D concentrations. This finding was substantiated in a meta-analysis. ANN NEUROL 2012.

Copyright © 2012 American Neurological Association.
PMID: 23225498
PDF is attached at the bottom of this page

>20ng (dotted line) has far fewer strokes than < 10 ng (sold line)

Low vitamin D is associated with many health problems, not just stroke
Low vitamin D associations  @ is.gd/heartvitd


Ischemic Stroke 1.9X more likely if low vitamin D - July 2015

Serum Vitamin D Status as a Predictor of Prognosis in Patients with Acute Ischemic Stroke
 Download the PDF from VitaminDWiki

See also VitaminDWiki

VitaminDWiki speculates that > 50 ng of vitamin D would reduce incidence of strokes by > 70%

Items in both categories Stroke and Meta-analysis are listed here:

Short url = http://is.gd/heartvitd

Attached files

ID Name Comment Uploaded Size Downloads
5658 1.9 X higher risk of ischemic stroke if lower vitamin D.pdf admin 12 Jul, 2015 113.45 Kb 1124
2268 Ischemic stroke.pdf admin 30 Mar, 2013 422.68 Kb 947
2267 Ischemic stroke forest plot.jpg admin 30 Mar, 2013 45.41 Kb 1562
2266 Heart study T1.jpg admin 30 Mar, 2013 91.98 Kb 761
1848 Stroke F2.jpg admin 18 Dec, 2012 24.54 Kb 1680