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Post-stroke fatigue cut in half by Vitamin D (just 600 IU daily in 3 months) – Nov 2021

Effect of Vitamin D Supplementation on the Prognosis of Post-stroke Fatigue: A Retrospective Cohort Study

Front Neurol. 2021 Nov 5;12:690969. doi: 10.3389/fneur.2021.690969.
Long Wang 1 2, Xue-Min Zhao 2, Fu-Yu Wang 3, Jun-Cang Wu 1, Yu Wang 4
Fatigue Severity Scale
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Levels of Vitamin D
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Objective: We aimed to evaluate the effect of vitamin D supplementation in post-stroke fatigue (PSF) patients with vitamin D deficiency on fatigue symptoms and outcomes. Methods: Patients with primary acute ischemic stroke (AIS) were recruited consecutively from July 2016 to June 2018. Post-stroke fatigue patients were screened out with the Fatigue Severity Scale (FSS) questionnaire, serum concentrations of 25-hydroxyvitamin D [25-(OH)-D] were assessed with enzyme-linked immunosorbent assay (ELISA), and neurological function was evaluated with FSS and modified Rankin Scale (mRS) scoring criteria. Post-stroke fatigue patients with vitamin D deficiency were divided into two groups: a study group in which patients received vitamin D supplementation (cholecalciferol, 600 IU/day) along with usual care, and a control group in which patients received usual care alone. At the end of 1 and 3 months after treatment, all PSE patients accepted re-measurement of serum vitamin D and re-evaluation of fatigue and neurological function.

Results: A total of 532 AIS patients were consecutively recruited to participate in this study. Patients without PSF, non-vitamin D deficiency, pre-stroke fatigue, or vitamin D supplementation were excluded from the study. In addition, patients who were lost to follow-up were also excluded. Finally, 139 out of 532 (26.1%) patients with PSF and vitamin D deficiency received vitamin D supplementation treatment. Fatigue Severity Scale score was significantly lower in the study group than in the control group at 1 month (t = -4.731, p < 0.01) and 3 months (t = -7.937, p < 0.01) after treatment. One month after treatment, mRS score in the study group was lower than that in the control group without statistical difference (t = -0.660, p > 0.05), whereas mRS was significantly higher in the study group than in the control group at 3 months after treatment (t = -4.715, p < 0.01).

Conclusions: Our results indicated that vitamin D supplementation could improve fatigue symptoms and neurological outcomes in PSF patients with vitamin D deficiency. Subject to replication in other settings, a randomized controlled trial (RCT) might be undertaken to validate the potential beneficial impact of vitamin D supplementation in post-stroke patients found to be vitamin D deficient.
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VitaminDWiki and Stroke

Similar to many previous studies, this study would have had far more benefits if it
  1) Had given a Vitamin D loading dose soon after the stroke
   2) Had used larger doses
   3) Had started Vitamin D years earlier, thus preventing the stroke


Created by admin. Last Modification: Monday November 22, 2021 23:19:20 GMT-0000 by admin. (Version 7)

Attached files

ID Name Comment Uploaded Size Downloads
16626 600 IU per day.jpg admin 22 Nov, 2021 26.44 Kb 393
16625 Stroke fatigue FSS.jpg admin 22 Nov, 2021 24.36 Kb 430
16624 Post stroke fatigue reduced by Vitamin D.pdf admin 22 Nov, 2021 722.03 Kb 292