Register Log In Login with facebook

Post stroke Calcitriol injections reduced edema and cell death (in rats) – Nov 2017

Vitamin D receptor activation influences the ERK pathway and protects against neurological deficits and neuronal death.

Int J Mol Med. 2017 Nov 9. doi: 10.3892/ijmm.2017.3249. [Epub ahead of print]
Yuan J1, Guo X2, Liu Z3, Zhao X4, Feng Y5, Song S6, Cui C7, Jiang P8.

VitaminDWiki Summary

Calcitriol was injected into rats abdomens 12 and 24 hours after ischaemic stroke-like event
This provides insight as to the exact nature of the Vitamin D benefits to stroke

Having a good level of vitamin D before a stroke greatly reduces the impact/occurrence of strokes
Getting Vitamin D to the brain quickly is essential to reduce the impact of a stroke
Very fast-acting vitamin D results from injection, IV, sublingual, and mouthwash
Standard-acting oral Vitamin D appears to take about 12 hours,
   which was the time delay for the first injection, so oral may be OK

See also VitaminDWiki

20 Most-visited pages in Stroke category in VitaminDWiki

Id Page Hits Last modification Creator Categories
1353 Overview Stroke and vitamin D 30849
20 Jan, 2018 12:28
admin Overviews
3413 Stroke 15395
22 Nov, 2017 11:46
ricks99 Stroke
4996 Fewer white spots in MRI brain scans if had more vitamin D – Jan 2014 6756
31 May, 2015 17:00
admin Multiple Sclerosis
Top news
4389 Following a stroke, a hip fracture is 6X more likely if low vitamin D – July 2001 4497
04 Mar, 2017 14:58
admin Top news
Falls and Fractures
21 Jun, 2018 18:42
admin Bone - Health
Vitamin D and Magnesium
Cystic Fibrosis
1872 80 percent recent increase in Strokes following pregnancy - July 2011 4089
26 Jun, 2012 16:43
admin Pregnancy
3561 Vitamin D associated with 50 percent less ischemic stroke – meta-analysis Aug 2012 3890
28 Feb, 2018 16:29
admin Meta-analysis of Vitamin D
Top news
1751 5X fewer hip fractures from Parkinson – Alzheimer – Stroke with enough sun – June 2011 3280
17 Jul, 2015 18:54
admin Deficiency of Vitamin D
Bone - Health
2172 Much higher death rate 10 years after TIA – Nov 2011 – vitamin D might help 3232
21 Aug, 2017 22:23
admin Mortality and D
1154 Too much and too little Calcium both increase death after strokes – Jan 2011 3177
26 Jun, 2012 16:50
admin Mortality and D
Vitamin D and Calcium
2431 100 mg more Magnesium in water associated with 8 percent reduction in stroke – Feb 2012 3056
26 Jun, 2012 16:39
admin Vitamin D and Magnesium
2334 Twice as many fatal strokes among whites who were low on vitamin D – Jan 2012 3030
04 Oct, 2017 14:42
admin Skin - Dark
6531 No longer depressed, but risk of stroke is still 1.7X higher (did not consider low vitamin D) – May 2015 2790
18 May, 2015 18:33
admin Depression
579 Stroke patients show dearth of vitamin D – 2005 2754
26 Jun, 2012 16:48
admin Trauma and surgery
1226 Strokes might be treated as well as prevented by vitamin D – Jan 2011 2708
29 Jul, 2013 03:18
admin Treatment by Vitamin D
3675 Low vitamin D is a risk factor for vascular diseases in African Americans - Aug 2012 2511
22 Jan, 2013 02:19
admin Skin - Dark
5518 Stroke mortality 3X worse among seniors with less than 26 ng of vitamin D – June 2014 2434
04 Oct, 2017 14:46
admin Stroke
5729 Stroke patients with low vitamin D were 10X more likely to become depressed – Aug 2014 2352
29 Dec, 2014 15:44
admin Depression
5988 Post stroke depression 9X more likely if low vitamin D – Dec 2014 2322
19 Apr, 2016 14:22
admin Depression
5962 Following a stroke, 10 ng less vitamin D associated with 2X more white matter hyperintensities – Nov 2014 2285
25 Feb, 2015 21:23
admin Stroke

Getting Vitamin D into your body has the following chart


 Download the PDF from VitaminDWiki

Previous studies have demonstrated that global cerebral ischemia (GCI) causes neurological deficits and neuronal cell apoptosis. Calcitriol, a biologically active metabolite of vitamin D, exerts its endocrinological influence via nuclear vitamin D receptor. It is being assessed as an emerging therapeutic strategy in models of various medical conditions, including acute brain injury. The purpose of the present study was to investigate the neuroprotective effects of calcitriol on GCI and further refine the potential underlying mechanisms. A total of 145 male rats were assigned to 5 groups as follows: Sham group, GCI group, calcitriol treatment group, PD98059 treatment group and vehicle-treated group. Brain water content and neurologic severity score were assessed to evaluate the brain edema and neurological deficits of rats. Histopathological changes and ultrastructures of cells were observed via hematoxylin and eosin stain and transmission electron microscopy, respectively. Immunofluorescent staining and western blot analysis were used to assess the expression of proteins and their co-localization at the molecular level. The results demonstrated that post-GCI administration of calcitriol attenuated brain edema and improved neurological function in rats.
Calcitriol also caused marked extracellular signal-regulated kinase 1/2 pathway activation, and thereby attenuated neuronal apoptosis.
The present study provided novel clues for understanding the mechanisms by which calcitriol exerts its neuroprotective activity in a rat model of GCI.

Edema at 7 days


Vitamin D Receptor activation increased by Calcitriol


Cell death indicator at 3 days


PMID: 29138801 DOI: 10.3892/ijmm.2017.3249

Created by admin. Last Modification: Thursday November 16, 2017 16:53:23 UTC by admin. (Version 5)

Attached files

ID Name Comment Uploaded Size Downloads
8748 Cell death at 3 days.jpg admin 16 Nov, 2017 16:38 12.24 Kb 84
8747 VDR increased.jpg admin 16 Nov, 2017 16:38 10.35 Kb 90
8746 Edema 7 days.jpg admin 16 Nov, 2017 16:36 11.44 Kb 90
8745 Calcitriol stroke.pdf PDF 2017 admin 16 Nov, 2017 16:36 1,020.92 Kb 34
See any problem with this page? Report it (FINALLY WORKS)