Decreasing serum 25-hydroxyvitamin D levels and risk of early neurological deterioration in patients with ischemic stroke.
Brain Behav. 2019 Mar;9(3):e01227. doi: 10.1002/brb3.1227
Hu W1, Liu D2, Li Q3, Wang L1, Tang Q1, Wang G1.
- Stroke risks increased if low Vitamin D: Death 3.6 X, recurrence 5.5 X – Meta-analysis Nov 2019
- Death after Ischemic Stroke 2.5 X more likely if less than 10 ng of Vitamin D – May 2019
- Ischemic stroke and low vitamin D – 3X higher risk of poor outcome, 6 X higher risk of a second stroke, Oct 2017
- Stroke outcome 6.9 X worse if black and overweight (all three related via low vitamin D) – March 2018
- Depression following a stroke is 2.7 X more likely if low vitamin D – Sept 2018
- Stroke outcome at 3 months was 3X worse if bad stroke and low vitamin D – Jan 2020
- Overview Stroke and vitamin D
- Stroke mortality 3X worse among seniors with less than 26 ng of vitamin D – June 2014
Items in BOTH of the categories Intervention and Stroke:
- Stroke patients getting weekly 50,000 IU Vitamin D did better – trial March 2021
- Stroke not prevented by just 2,000 IU of vitamin D plus 840 mg Omega-3 (VITAL) – Feb 2020
- Stroke patients need more than 2,000 IU of vitamin D (found this time in Japan) – RCT June 2019
- Improved recovery from ischemic stroke with Vitamin D (300,000 IU injection) – RCT June 2018
- Ischaemic stroke – Vitamin D doubled survival (Injection followed by monthly 60,000 IU) – RCT Aug 2016
BACKGROUND AND AIMS:
Vitamin D deficiency has been linked to a higher risk of ischemic stroke. We therefore explored the relationship between serum 25-hydroxyvitamin D [25(OH)D] levels and early neurological deterioration (END) after acute ischemic stroke in a hospital-based prospective study.
From June 2016 to June 2018, patients with ischemic stroke within 48 hr from symptom onset were consecutively recruited. Serum 25(OH)D levels were measured at admission.
END was defined as an increase of
- ≥1 point in motor power or
- ≥2 points in the total National Institute of Health Stroke Scale score within 7 days after admission.
Multiple logistic regression models were performed to calculate the odds ratio (OR) and confidence intervals (CI) of 25(OH)D levels in predicting END.
A total of 478 subjects were enrolled, of which 136 (28.5%) patients developed END. The mean 25(OH)D levels were 49.5 ± 15.8 nmol/L. Univariate logistic regression analysis showed that advanced age, white matter lesions, high level of body mass index, diastolic blood pressure, fasting blood glucose and homocysteine, and low 25(OH)D levels were associated with END. Furthermore, multivariate regression analysis demonstrated that the first quartile of 25(OH)D concentrations [OR, 2.628; 95% CI,1.223-5.644; p = 0.013] was independently risk factor for END.
This study illustrated that lower 25(OH)D levels might be associated with an increasing risk of END in acute ischemic stroke patients.