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4.8 X more likely to die within 28 days of ICU if low Vitamin D - Jan 2024

Low plasma vitamin D is associated with increased 28-day mortality and worse clinical outcomes in critically ill patients

BMC Nutrition volume 10, Article number: 6 (2024) https://doi.org/10.1186/s40795-023-00801-1
Fatemeh Sistanian, Alireza Sedaghat, Mohaddeseh Badpeyma, Majid Khadem Rezaiyan, Ahmad Bagheri Moghaddam, Golnaz Ranjbar, Mostafa Arabi, Mohammad Bagherniya & Abdolreza Norouzy

Background & objective
Patients in the intensive care unit have a high prevalence of vitamin D deficiency (VDD). In the present study, clinical outcomes in the ICU were analyzed with vitamin D status.

Materials and methods
In this prospective, multicenter study, sampling was conducted on seven ICUs in three hospitals. Within the first 24 h of ICU admission, patient’s serum vitamin D levels were measured, and their disease severity was monitored using the scores of acute physiologic assessment and chronic health evaluation II (APACHE II), sequential organ failure assessment (SOFA), and the modified Nutrition Risk in Critically ill (mNUTRIC) score.

A total of 236 patients were enrolled in this study, of which 163 (69.1%) had lower vitamin D levels than 20 ng/ml upon ICU admission. The patients with VDD had higher APACHE II scores)P = 0.02), SOFA scores (P < 0.001), and mNUTRIC scores (P = 0.01). Patients with sufficient levels of vitamin D (> 30 ng/ml) had a shorter stay at ICU (P < 0.001). VDD was independently associated with 28-day mortality (OR: 4.83; 95% CI: 1.63–14.27; P = 0.004).

The data showed that VDD was common among the critically ill and was related to a more severe course of illness and a higher mortality rate.
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VitaminDWiki – Vitamin D is needed before most surgeries – many studies and RCTs contains

{FONT(size="17")} Summary of 20+ studies {FONT}

  1. Loading doses of 300,000 IU Vitamin D have been frequently used for adults
    More than 300,000 IU is sometimes needed for adults
    infants-Children might only need 10,000 IU per kg
  2. Loading dose for the ICU should be given in a single day
    An oral dose does not result in a full response for 3+ days
    An injection does not result in a full response for several weeks
  3. A gut-friendly form of Vitamin D should be used if patient has poor digestion
    Nanoemulsion sublingual or topical are fast acting (hours)
      Any form of vitamin D given just before/after surgery is better than none
  4. All of the above also applies to ICU (Intensive Care Unit)
    4.8 X more likely to die within 28 days of ICU if low Vitamin D - Jan 2024
  5. Vitamin D3, not Vitamin D2 should be used
  6. Note: Some Chemotherapies are amplified so much by Vitamin D as to result in death if dose size is not decreased

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20X fewer problems after surgery (noncardiac) if a high level of Vitamin D

The Association of Serum Vitamin D Concentration with Serious Complications After Noncardiac Surgery- 2014
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VitaminDWiki - {SQL(db=>vitamind)}SELECT COUNT(*) FROM (SELECT catObjectId, COUNT(*) FROM `tiki_category_objects` WHERE categId = 73 OR categId = 64 GROUP BY catObjectId HAVING COUNT(*) > 1) AS categs INNER JOIN tiki_objects ON tiki_objects.objectId = categs.catObjectId WHERE type = "wiki page"{SQL} studies in both categories Surgery and Loading Dose

This list is automatically updated
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Attached files

ID Name Comment Uploaded Size Downloads
20640 Survive ICU.png admin 10 Jan, 2024 42.24 Kb 61
20639 ICU mortality_CompressPdf.pdf admin 10 Jan, 2024 281.28 Kb 16