Loading...
 
Toggle Health Problems and D

Less likely to die of various causes if higher Vitamin D (data from 300,000 people) – Oct 2022


Vitamin D Deficiency Increases Mortality Risk in the UK Biobank : A Nonlinear Mendelian Randomization Study

Ann Intern Med . 2022 Oct 25.doi: 10.7326/M21-3324.
Joshua P Sutherland1 joshua.sutherland at mymail.unisa.edu.au , Ang Zhou 2 , Elina Hyppönen 2 elina.hypponen at unisa.edu.au

A few of the mortality charts: All-cause, Cardio, Respiratory, Cancer (need at least 40 ng)

Image

Image

Image

Image

Image

Background: Low vitamin D status is associated with increased mortality, but randomized trials on severely deficient participants are lacking.

Objective: To assess genetic evidence for the causal role of low vitamin D status in mortality.

Design: Nonlinear Mendelian randomization analyses.

Setting: UK Biobank, a large-scale, prospective cohort from England, Scotland, and Wales with participants recruited between March 2006 and July 2010.

Participants: 307 601 unrelated UK Biobank participants of White European ancestry (aged 37 to 73 years at recruitment) with available measurements of 25-hydroxyvitamin D (25-(OH)D) and genetic data.

Measurements: Genetically predicted 25-(OH)D was estimated using 35 confirmed variants of 25-(OH)D. All-cause and cause-specific mortality (cardiovascular disease [CVD], cancer, and respiratory) were recorded up to June 2020.

Results: There were 18 700 deaths during the 14 years of follow-up. The association of genetically predicted 25-(OH)D with all-cause mortality was L-shaped (P for nonlinearity < 0.001), and risk for death decreased steeply with increasing concentrations until 50 nmol/L. Evidence for an association was also seen in analyses of mortality from cancer, CVD, and respiratory diseases (P ≤ 0.033 for all outcomes). Odds of all-cause mortality in the genetic analysis were estimated to increase by 25% (odds ratio, 1.25 [95% CI, 1.16 to 1.35]) for participants with a measured 25-(OH)D concentration of 25 nmol/L compared with 50 nmol/L.

Limitations: Analyses were restricted to a White European population. A genetic approach is best suited to providing proof of principle on causality, whereas the strength of the association is approximate.

Conclusion: Our study supports a causal relationship between vitamin D deficiency and mortality. Additional research needs to identify strategies that meet the National Academy of Medicine's guideline of greater than 50 nmol/L and that reduce the premature risk for death associated with low vitamin D levels.
 Download the PDF from VitaminDWiki


This study underestimates the problem by about 2X by ignoring 6+ genes that reduce Vitamin D levels in blood from getting to cells

VitaminDWiki - 27 studies in both categories Mortality and Cardiovascular

This list is automatically updated


VitaminDWiki - 7 studies in both categories Mortality and Breathing

This list is automatically updated


VitaminDWiki Mortality pages with CANCER in title (34 as of Oct 2022)

This list is automatically updated

Items found: 37
Title Modified
Fewer deaths (All-cause, Cardiovascular, Cancer) when Vitamin D levels are above 36 ng – April 2024 01 May, 2024
People with Cancer having more than 30 ng of Vitamin D are 40% less likely to die (of any cause) – Nov 2023 23 Nov, 2023
Death of women from cancer 24% less likely if 20 ng more vitamin D – meta-analysis Sept 2013 31 Jul, 2023
Cancer incidence or mortality not changed by small Vitamin D doses: 2021-2023 01 May, 2023
Prostate Cancer death 40 percent less likely if 40 ng level of vitamin D – Meta-analysis Oct 2018 30 Apr, 2023
Cancer mortality reduced 40 pcnt by 2000 IU Vitamin D daily if normal weight – Meta-analysis June 2022 03 Jul, 2022
Cancer incidence and death reduced by both Vitamin D and UVB – Grant Oct 2021 15 Oct, 2021
Cancer mortality not reduced by small vitamin D doses - Sept 2021 21 Sep, 2021
Cancer death (non-skin) 2.3 X more likely if low Vitamin D – Aug 2021 17 Aug, 2021
Deaths after Cancer Surgery higher in blacks (probably low vitamin D) – Dec 2020 10 Jan, 2021
Cancer patients in ICU with low vitamin D were 3.4 X more likely to die within a year – Dec 2020 31 Dec, 2020
Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses Sept 2020 09 Nov, 2020
Cancer is leading cause of death - Vitamin D and Receptor activators help 09 Nov, 2019
Mortality increased: 4X Cancer, 5X Diabetes if eat a lot of meat protein – March 2014 08 Nov, 2019
Vitamin D Supplements Reduce Cancer Mortality – Greger Sept 2019 10 Sep, 2019
Cancer with low Vitamin D increases Mortality by 13 percent – meta-analysis Feb 2019 05 Jul, 2019
People supplemented with Vitamin D had 13 percent fewer Cancer deaths – Meta-analysis of RCT June 2019 05 Jul, 2019
Cancer incidence and mortality is decreased if 40-60 ng of Vitamin D – April 2019 07 May, 2019
Vitamin D reduced Breast Cancer mortality in 9 out of 9 studies, yet still no consensus – April 2019 13 Apr, 2019
Cancer patients 64% less likely to die if have high level of vitamin D – Dec 2011 26 Nov, 2018
Vitamin D reduces the risk of Breast Cancer, improves treatment, and improves survival 10 Sep, 2018
The “Deadly Breast Cancer Gene” Is A Myth, Lancet Study Confirms – Jan 2018 13 Jan, 2018
Lung Cancer death 60 percent less likely if high level of vitamin D – 2 meta-analysis 2017 29 Dec, 2017
Breast Cancer Mortality reduced 60 percent if more than 60 ng of Vitamin D – meta-analysis June 2017 13 Jun, 2017
Death after Breast Cancer 2 times less likely if take lots of Magnesium – Dec 2015 15 Jun, 2016
Fewer heart attacks, hip fractures and deaths if more skin cancer – Sept 2013 09 Nov, 2014
Colorectal and Breast Cancer – Vitamin D is associated with fewer deaths – meta-analysis Feb 2014 30 Sep, 2014
Cancer incidence not reduced by 1100 IU of vitamin D (proven again) but mortality decreased – June 2014 17 Jun, 2014
Cancer survival 4 percent more likely with just a little more vitamin D (4 ng) - meta-analysis July 2014 12 May, 2014
More survive Breast Cancer if more vitamin D – 2X fewer deaths with just 30 ng -meta-analysis March 2014 08 May, 2014
Death due to breast cancer reduced 40 percent if high vitamin D – meta-analysis April 2014 08 Apr, 2014
Breast Cancer survival 2X more likely if vitamin D sufficient – meta-analysis May 2013 06 Mar, 2014
Vitamin D and Cancer Mortality – review Jan 2013 17 Sep, 2013
Mortality and Cancer varies with latitude in France too – 2010 26 Oct, 2012
More US deaths due to cancer than heart if dark skinned – Sept 2012 18 Sep, 2012
Lack of solar UVB in US is associated with some Cancers - 2006 28 Dec, 2011
Solar radiation, vitamin D and cancer incidence and mortality in Norway 13 Apr, 2010

VitaminDWiki - Mortality category contains

People die sooner if they have low vitamin D
Mortality is.gd/VitaminDMortality
click on image for details

There are 315 articles in Mortality category

Vitamin D Biobank study by many of the same authors - May 2021 (huge change in levels with Race and Season)

Differences and determinants of vitamin D deficiency among UK biobank participants: A cross-ethnic and socioeconomic study
Clinical NutritionVolume 40, Issue 5, May 2021, Pages 3436-3447 https://doi.org/10.1016/j.clnu.2020.11.019
Joshua P.Sutherland a, AngZhou a Matthew J.Leach b ElinaHyppönen ac

Image

Image
 Download the PDF from Sub-Hub via VitaminDWiki


Created by admin. Last Modification: Wednesday August 30, 2023 16:40:18 GMT-0000 by admin. (Version 12)

Attached files

ID Name Comment Uploaded Size Downloads
18708 Biobank race.jpg admin 25 Oct, 2022 32.13 Kb 235
18707 2020 biobank.jpg admin 25 Oct, 2022 40.39 Kb 265
18706 sutherland2020_CompressPdf.pdf admin 25 Oct, 2022 362.43 Kb 152
18705 Cancer biobank.jpg admin 25 Oct, 2022 30.76 Kb 561
18704 Adjustd Respiratory.jpg admin 25 Oct, 2022 34.77 Kb 360
18703 Respiratory biobank.jpg admin 25 Oct, 2022 35.84 Kb 354
18702 CVD biobank.jpg admin 25 Oct, 2022 24.48 Kb 362
18701 Call cause bio-bank.jpg admin 25 Oct, 2022 24.52 Kb 587
18700 Mortality biobank.pdf admin 25 Oct, 2022 197.00 Kb 158