Table of contents
- Vitamin D Deficiency Increases Mortality Risk in the UK Biobank : A Nonlinear Mendelian Randomization Study
- VitaminDWiki -
22 studies in both categories Mortality and Cardiovascular - VitaminDWiki -
7 studies in both categories Mortality and Breathing - VitaminDWiki Mortality pages with CANCER in title (34 as of Oct 2022)
- VitaminDWiki - Mortality category contains
- Vitamin D Biobank study by many of the same authors - May 2021 (huge change in levels with Race and Season)
Vitamin D Deficiency Increases Mortality Risk in the UK Biobank : A Nonlinear Mendelian Randomization Study
Ann Intern Med . 2022 Oct 25.doi: 10.7326/M21-3324.
Joshua P Sutherland1 joshua.sutherland at mymail.unisa.edu.au , Ang Zhou 2 , Elina Hyppönen 2 elina.hypponen at unisa.edu.auA few of the mortality charts: All-cause, Cardio, Respiratory, Cancer (need at least 40 ng)
Background: Low vitamin D status is associated with increased mortality, but randomized trials on severely deficient participants are lacking.
Objective: To assess genetic evidence for the causal role of low vitamin D status in mortality.
Design: Nonlinear Mendelian randomization analyses.
Setting: UK Biobank, a large-scale, prospective cohort from England, Scotland, and Wales with participants recruited between March 2006 and July 2010.
Participants: 307 601 unrelated UK Biobank participants of White European ancestry (aged 37 to 73 years at recruitment) with available measurements of 25-hydroxyvitamin D (25-(OH)D) and genetic data.
Measurements: Genetically predicted 25-(OH)D was estimated using 35 confirmed variants of 25-(OH)D. All-cause and cause-specific mortality (cardiovascular disease [CVD], cancer, and respiratory) were recorded up to June 2020.
Results: There were 18 700 deaths during the 14 years of follow-up. The association of genetically predicted 25-(OH)D with all-cause mortality was L-shaped (P for nonlinearity < 0.001), and risk for death decreased steeply with increasing concentrations until 50 nmol/L. Evidence for an association was also seen in analyses of mortality from cancer, CVD, and respiratory diseases (P ≤ 0.033 for all outcomes). Odds of all-cause mortality in the genetic analysis were estimated to increase by 25% (odds ratio, 1.25 [95% CI, 1.16 to 1.35]) for participants with a measured 25-(OH)D concentration of 25 nmol/L compared with 50 nmol/L.
Limitations: Analyses were restricted to a White European population. A genetic approach is best suited to providing proof of principle on causality, whereas the strength of the association is approximate.
Conclusion: Our study supports a causal relationship between vitamin D deficiency and mortality. Additional research needs to identify strategies that meet the National Academy of Medicine's guideline of greater than 50 nmol/L and that reduce the premature risk for death associated with low vitamin D levels.
Download the PDF from VitaminDWiki
This study underestimates the problem by about 2X by ignoring 6+ genes that reduce Vitamin D levels in blood from getting to cells
VitaminDWiki -
22 studies in both categories Mortality and Cardiovascular This list is automatically updated
- Less likely to die of various causes if higher Vitamin D (data from 300,000 people) – Oct 2022
- Metabolic Syndrome with low vitamin D increases CVD mortality by 1.7 X – July 2022
- 1.7 X less risk of Heart Failure death if previously had taken any amount of vitamin D - Jan 2022
- 1.7 X less risk of Heart Failure death if previously had taken any amount of vitamin D - Jan 2022
- Those raising Vitamin D above 30 ng were 1.4 X less likely to die of Heart Attack (VA 19 years) – Oct 2021
- Omega-3 reduced cardiovascular deaths by 16 percent (427,678 people) – March 2020
- Cardiovascular death 1.5X more likely if less than 20 ng of Vitamin D – 22nd meta-analysis Nov 2019
- Mortality associated with Vitamin K insufficiency (PREVEND Study) – Nov 2017
- Cardiovascular deaths 12 percent less likely if have 10 ng more vitamin D – meta-analysis March 2017
- 7X increased chance of death if coronary artery disease and low vitamin D – Oct 2013
- Fewer heart attacks, hip fractures and deaths if more skin cancer – Sept 2013
- Vitamin D protects against many types of health problems – review May 2013
- Almost 6X more likely to die after coronary bypass if vitamin D deficient – Dec 2012
- Predicted cardiac surgery death associated with low vitamin D levels – Dec 2012
- 3 X increased chance of death if have asthma – study of 200,000 people over 10 years – Nov 2012
- Low levels of vitamin D associated with all cause mortality – Oct 2012
- Death in less than 2 years of Heart Failure associated with low vitamin D - April 2012
- Heart Failure early death 2X more likely if less than 20 nanograms of vitamin D – June 2012
- Chance of death after heart failure reduced by 1000 IU of vitamin D – Feb 2012
- Heart patients 10 percent more likely to die for every 4 ng less vitamin D – May 2011
- Did not find association between vitamin D and cardiovascular mortality – Sept 2010
- Table of outcomes for seniors vs vitamin D level
VitaminDWiki -
7 studies in both categories Mortality and Breathing This list is automatically updated
- Less likely to die of various causes if higher Vitamin D (data from 300,000 people) – Oct 2022
- COVID-19 lung death 4X more likely in Iran if less than 25 ng of vitamin D – Oct 30, 2020
- Respiratory deaths in seniors – 40 percent are attributable to low vitamin D – Aug 2020
- COVID ARDS deaths 2X more likely if less than 10 ng of Vitamin D – Aug 8, 2020
- Vitamin D predicts good health and long life in seniors, review of 20 cohort studies – Oct 2019
- 3 X increased chance of death if have asthma – study of 200,000 people over 10 years – Nov 2012
- Seniors on mechanical ventilation having very low vitamin D died sooner – July 2012
VitaminDWiki Mortality pages with CANCER in title (34 as of Oct 2022)
This list is automatically updated
Items found: 35
VitaminDWiki - Mortality category contains
People die sooner if they have low vitamin D
There are
click on image for details292 articles in Mortality category 28 Mortality Meta-analyses This list is automatically updated
- Maternal pregnancy problems if Vitamin D is less than 40 ng – meta-analysis Oct 2022
- COVID-19 mortality extrapolates to zero at 50 ng of vitamin D – 18th Meta-analysis Sept 2021
- Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses Sept 2020
- Cardiovascular death 1.5X more likely if less than 20 ng of Vitamin D – 22nd meta-analysis Nov 2019
- People supplemented with Vitamin D had 13 percent fewer Cancer deaths – Meta-analysis of RCT June 2019
- Cancer with low Vitamin D increases Mortality by 13 percent – meta-analysis Feb 2019
- Low Vitamin D is associated with dying sooner (70 studies) – meta-analysis Jan 2019
- Prostate Cancer death 40 percent less likely if 40 ng level of vitamin D – Meta-analysis Oct 2018
- Review of meta-analyses of non-skeletal benefits of vitamin D (Mortality, RTI, etc) – July 2017
- Chronic Kidney Disease mortality is 60 percent less likely if good vitamin D – meta-analysis July 2017
- Lung Cancer death 60 percent less likely if high level of vitamin D – 2 meta-analysis 2017
- Breast Cancer Mortality reduced 60 percent if more than 60 ng of Vitamin D – meta-analysis June 2017
- Cardiovascular deaths 12 percent less likely if have 10 ng more vitamin D – meta-analysis March 2017
- ICU patients 30 percent less likely to die if have enough vitamin D – meta-analysis Nov 2016
- Less likely to die if have enough vitamin D - Meta-analysis June 2014
- Cancer survival 4 percent more likely with just a little more vitamin D (4 ng) - meta-analysis July 2014
- Death due to breast cancer reduced 40 percent if high vitamin D – meta-analysis April 2014
- Vitamin D reduces risk of cause specific death, unless it is D2 – meta-analysis BMJ April 2014
- More survive Breast Cancer if more vitamin D – 2X fewer deaths with just 30 ng -meta-analysis March 2014
- Colorectal and Breast Cancer – Vitamin D is associated with fewer deaths – meta-analysis Feb 2014
- Death of women from cancer 24 percent less likely if 20 ng more vitamin D – meta-analysis Sept 2013
- Chance of dying increases by 25 percent in seniors if low vitamin D – Meta-analysis July 2013
- Breast Cancer survival 2X more likely if vitamin D sufficient – meta-analysis May 2013
- Vitamin D with Calcium reduces mortality by 7 percent – meta-analysis May 2012
- Death rate reduced 8 percent for 8 nanogram more vitamin D – meta-analysis Feb 2012
- 40 ng Vitamin D perhaps optimal for reduced mortality – Meta-analysis Jan 2012
- Vitamin D3 but not D2 reduces mortality – meta-analysis July 2011
- Vitamin D and mortality a meta-analysis of RCT - 2008
Vitamin D Biobank study by many of the same authors - May 2021 (huge change in levels with Race and Season)
Differences and determinants of vitamin D deficiency among UK biobank participants: A cross-ethnic and socioeconomic study
Clinical NutritionVolume 40, Issue 5, May 2021, Pages 3436-3447 https://doi.org/10.1016/j.clnu.2020.11.019
Joshua P.Sutherland a, AngZhou a Matthew J.Leach b ElinaHyppönen ac
Download the PDF from Sub-Hub via VitaminDWikiLess likely to die of various causes if higher Vitamin D (data from 300,000 people) – Oct 2022(Cached) Printer Friendly Follow this page for updates409 visitors, last modified 05 Nov, 2022, This page is in the following categories (# of items in each category)Attached files
ID Name Comment Uploaded Size Downloads 18708 Biobank race.jpg admin 25 Oct, 2022 17:21 32.13 Kb 90 18707 2020 biobank.jpg admin 25 Oct, 2022 17:21 40.39 Kb 114 18706 sutherland2020_CompressPdf.pdf admin 25 Oct, 2022 17:20 362.43 Kb 41 18705 Cancer biobank.jpg admin 25 Oct, 2022 16:25 30.76 Kb 247 18704 Adjustd Respiratory.jpg admin 25 Oct, 2022 16:02 34.77 Kb 178 18703 Respiratory biobank.jpg admin 25 Oct, 2022 16:02 35.84 Kb 185 18702 CVD biobank.jpg admin 25 Oct, 2022 16:01 24.48 Kb 177 18701 Call cause bio-bank.jpg admin 25 Oct, 2022 16:01 24.52 Kb 209 18700 Mortality biobank.pdf PDF 2022 admin 25 Oct, 2022 15:59 197.00 Kb 47 - VitaminDWiki -