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Cardiovascular death 1.5X more likely if less than 20 ng of Vitamin D – 22nd meta-analysis Nov 2019

The association between circulating 25-hydroxyvitamin D and cardiovascular diseases: a meta-analysis of prospective cohort studies.

BMC Cardiovasc Disord. 2019 Nov 7;19(1):248. doi: 10.1186/s12872-019-1236-7.
Gholami F1,2, Moradi G2,3, Zareei B2,4, Rasouli MA5,6, Nikkhoo B7, Roshani D2,3, Ghaderi E2,3.

VitaminDWiki

Heart Failure and Vitamin D meta-analyses - 2016, 2019 contains same results by a different study
   CVD mortality 1.5X higher if <20 ng of vitamin D - meta-analysis 2019
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Studies in both VitaminDWiki categories Cardiovascular and Meta-analysis:

 Download the PDF from VitaminDWiki
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BACKGROUND:
There is a controversy about the association between vitamin D and cardiovascular diseases (CVDs). The effect of serum 25-OH-vitD on the risk of CVDs was evaluated.

METHODS:
Major electronic databases including Scopus, Science Direct, and PubMed were searched. All prospective cohort studies on the relationship between vitamin D status and CVDs conducted between April 2000 and September 2017 were included, regardless language. The study participants were evaluated regardless of their age, sex, and ethnicity. The Newcastle-Ottawa Scale was used to assess the quality of the studies. Two investigators independently selected the studies and extracted the data. The designated effects were risk ratio (RR) and hazard ratio (HR). The random effects model was used to combine the results.

RESULTS:
A meta-analysis of 25 studies with 10,099 cases of CVDs was performed. In general, a decrease in the level of vitamin D was associated with a higher relative risk of CVDs (incidence-mortality combined) (RR = 1.44, 95% CI: 1.24-1.69). This accounts for 54% of CVDs mortality rate (RR = 1.54, 95% CI: 1.29-1.84(. However, no significant relationship was observed between the vitamin D status and incidence of CVDs (RR = 1.18, 95% CI: 1-1.39). In general, low serum vitamin D level increased the risk of CVD by 44% (RR = 1.44, 95% CI: 1.24-1.69). It also increased the risk of CVD mortality (RR = 1.54, 95% CI: 1.29-1.84) and incidence rates (RR = 1.18, 95% CI: 1-1.39).

CONCLUSIONS:
The findings showed that vitamin D deficiency increases the CVDs mortality rate. Due to the limited number of studies on patients of the both genders, further research is suggested to separately evaluate the effect of vitamin D status on CVD in men and women.

Attached files

ID Name Comment Uploaded Size Downloads
12957 CVD Mortality.jpg admin 11 Nov, 2019 11:22 55.35 Kb 17
12956 CVD death meta.pdf PDF 2019 admin 11 Nov, 2019 11:21 1,023.55 Kb 2
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