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Cardiovascular deaths 12 percent less likely if have 10 ng more vitamin D – meta-analysis March 2017

Serum 25-hydroxyvitamin D and the risk of cardiovascular disease: dose-response meta-analysis of prospective studies.

Am J Clin Nutr. 2017 Mar 1. pii: ajcn140392. doi: 10.3945/ajcn.116.140392. [Epub ahead of print]
Zhang R1,2,3,4, Li B1, Gao X5, Tian R1, Pan Y1,2,3,4, Jiang Y1,2,3,4, Gu H1,2,3,4, Wang Y1,2,3,4, Wang Y1,2,3,4, Liu G6,2,3,4.
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
2China National Clinical Research Center for Neurological Diseases, Beijing, China.
3Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China.
4Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China; 5Department of Nutritional Sciences, Pennsylvania State University, State College, PA.
6Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; liugaifen1997 at 163.com.

25% less risk of dying of CVD with high level of Vitamin D

Based on many studies, VitaminDWiki suspects a 60% reduction in CVD mortality in those having

  • Enough Vitamin D
  • Enough Magnesium
  • Enough Omega-3
  • Enough Vitamin K2
  • Reduced Calcium

For every 10 nanogram/mL higher vitamin D
10% less likely to have CVD Events
12% less likely to have CVD death

Cardiovascular category listing has 511 items along with related searches

The Meta-analyses of Cardiovascular and Vitamin D

Vitamin D Intervention AND Cardiovascular studies

Cardiovascular category starts with the following

511 items In Cardiovascular category

Cardiovascular category is associated with other categories: Diabetes 31, Omega-3 31 , Vitamin K 25 , Intervention 22 . Mortality 20 , Skin - Dark 18 , Magnesium 17 , Calcium 14 , Hypertension 14 , Trauma and surgery 13 , Stroke 13 , Kidney 12 , Metabolic Syndrome 11 , Seniors 10 , Pregnancy 8 as of Aug 2022

Cholesterol, Statins

Studies in all 3 categories: Cardiovascular, Meta-analysis and Mortality

Pages listed in BOTH the categories Mortality and Cardiovascular

Background: During the past decade, an increasing number of prospective studies have focused on the association between vitamin D and cardiovascular disease (CVD). However, the evidence on the relation between serum 25-hydroxyvitamin D [25(OH)D] and the risk of overt CVD is inconclusive.

Objective: We performed a dose-response meta-analysis to summarize and prospectively quantify the RR of low serum 25(OH)D concentration and total CVD (events and mortality).

Design: We identified relevant studies by searching PubMed and EMBASE up to December 2015 and by hand-searching reference lists. Prospective studies based on the general population and reported RRs and 95% CIs were included. A random-effects model was used to calculate the pooled RRs. Nonlinear association was assessed by using restricted cubic spline analyses.

Results: A total of 34 publications with 180,667 participants were eligible for the meta-analysis. We included 32 publications (27 independent studies) for total CVD events and 17 publications (17 independent studies) for CVD mortality. We observed an inverse association between serum 25(OH)D and total CVD events and CVD mortality, and the pooled RRs per 10-ng/mL increment were 0.90 (95% CI: 0.86, 0.94) for total CVD events and 0.88 (95% CI: 0.80, 0.96) for CVD mortality. A nonlinear association was detected for total CVD events (P-nonlinear < 0.001) and CVD mortality (P-nonlinear = 0.022).

Conclusion: Serum 25(OH)D concentration was inversely associated with total CVD events and CVD mortality from the observed studies.

© 2017 American Society for Nutrition. Publisher rents this PDF as well as all other PDFs for a total of $25

PMID: 28251933 DOI: 10.3945/ajcn.116.140392

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