Vitamin D deficiency as a risk factor for sudden cardiac arrest: A multicenter case-control study
Nutr Metab Cardiovasc Dis . 2024 May 10:S0939-4753(24)00175-3. Doi: 10.1016/j.numecd.2024.05.007 PDF behind paywall
Mi Jin Lee 1, Haewon Jung 2, Sang Do Shin 3, Young Sun Ro 3, Jeong Ho Park 3, Young-Il Roh 4, Woo Jin Jung 4, Ju Ok Park 5, Seung Min Park 6, Sang-Chul Kim 7, Jonghwan Shin 8, Yong Won Kim 9, Ju-Young Hong 10, Hyun Ho Ryu 11, Su Jin Kim 12, Jong-Hak Park 12, Won Young Kim 13, Gun Tak Lee 14, Sung Bum Oh 15; CATURES II Consortium
Background and aims: Vitamin D is known to influence the risk of cardiovascular disease, which is a recognized risk factor for sudden cardiac arrest (SCA). However, the relationship between vitamin D and SCA is not well understood. Therefore, this study aims to investigate the association between vitamin D and SCA in out-of-hospital cardiac arrest (OHCA) patients compared to healthy controls.
Methods and results: Using the Phase II Cardiac Arrest Pursuit Trial with Unique Registration and Epidemiologic Surveillance (CAPTURES II) registry, a 1:1 propensity score-matched case-control study was conducted between 2017 and 2020. Serum 25-hydroxyvitamin D (vitamin D) levels in patients with OHCA (454 cases) and healthy controls (454 cases) were compared after matching for age, sex, cardiovascular risk factors, and lifestyle behaviors. The mean vitamin D levels were 14.5 ± 7.6 and 21.3 ± 8.3 ng/mL among SCA cases and controls, respectively. Logistic regression analysis was used adjusting for cardiovascular risk factors, lifestyle behaviors, corrected serum calcium levels, and estimated glomerular filtration rate (eGRF). The adjusted odds ratio (aOR) for vitamin D was 0.89 (95% confidence interval CI 0.87-0.91). The dose-response relationship demonstrated that vitamin D deficiency was associated with SCA incidence (severe deficiency, aOR 10.87, 95% CI 4.82-24.54; moderate deficiency, aOR 2.24, 95% CI 1.20-4.20).
Conclusion: Vitamin D deficiency was independently and strongly associated with an increased risk of SCA, irrespective of cardiovascular and lifestyle factors, corrected calcium levels, and eGFR.
21+ VitaminDWiki pages have SUDDEN CARDIAC or CARDIOVASCULAR DEATH in the title
This list is automatcially updated
Items found: 22
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5X lower Cardiovascular death rate in regions consuming more fish and vegetables, (and lower obesity) – Dec 2023 |
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04 Feb, 2025 |
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Sudden Cardiac Arrest 10.8 X more likely if severe vitamin D deficiency – May 2024 |
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13 Jun, 2024 |
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Fewer deaths (All-cause, Cardiovascular, Cancer) when Vitamin D levels are above 36 ng – April 2024 |
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01 May, 2024 |
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Risk of Cardiovascular death decreased 5X (lowest to highest Vitamin D level)- Feb 2024 |
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19 Feb, 2024 |
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Postmenopausal women half as likely to have a cardiovascular death if high vitamin D (NHANES) – Dec 2023 |
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13 Dec, 2023 |
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Vaccine Clinical Trial - cardiovascular death 3.7X more likely if vaccinated - preprint Sept 2023 |
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06 Sep, 2023 |
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Death rates of Cardiovascular patients keep decreasing until 90 nmol of Vitamin D - May 2023 |
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08 May, 2023 |
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Cardiovascular death 1.5X more likely if less than 20 ng of Vitamin D – 22nd meta-analysis Nov 2019 |
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29 Aug, 2022 |
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Recurrrent Cardiovascular deaths cut in half if 10 ng more Vitamin D – meta-analysis Sept 2021 |
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18 Oct, 2021 |
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Omega-3 reduced cardiovascular deaths by 16 percent (427,678 people) – March 2020 |
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10 Apr, 2020 |
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Sudden Cardiac Arrest – 2.8 X higher risk if low vitamin D – 2019 |
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26 Dec, 2019 |
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Cardiovascular death 40 percent more likely in a decade if chest pain and low Vitamin D - March 2018 |
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07 Mar, 2018 |
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Cancer diagnosis increased cardiovascular death 5 X in the next week – 2012 |
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18 Dec, 2017 |
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6X worse Sudden Cardiac Arrest outcome if low vitamin D – April 2014 |
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28 Aug, 2017 |
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Cardiovascular deaths 12 percent less likely if have 10 ng more vitamin D – meta-analysis March 2017 |
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03 Mar, 2017 |
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Cardiovascular death reduction in dark skin migrants by just 1,000 IU of vitamin D – May 2015 |
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04 Jan, 2017 |
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Cardiovascular death: 9 percent due to hypertension or air pollution, 7 percent: low Vitamin K2 or smoking – Oct 2016 |
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30 Oct, 2016 |
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Cardiovascular death: 9 percent hypertension and air pollution, 7 percent Vit K2 and smoking – Oct 2016 |
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30 Oct, 2016 |
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Sudden cardiac arrest 6X worse outcome if low vitamin D – Nov 2014 |
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08 Dec, 2014 |
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6X worse Sudden Cardiac Arrest outcome if low vitamin – April 2014 |
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10 Nov, 2014 |
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More than 400 mg of Calcium supplements caused cardiovascular deaths in men - Feb 2013 |
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05 Feb, 2013 |
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Vitamin D reduces both death rate and cardiovascular disease – Sept 2010 |
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18 Sep, 2010 |