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Weekly response to semi-activated vitamin D slightly better than standard – RCT Nov 2019

Effects of Weekly Supplementation of Cholecalciferol and Calcifediol Among the Oldest-Old People: Findings From a Randomized Pragmatic Clinical Trial

Nutrients. 2019 Nov; 11(11): 2778. online 2019 Nov 15. doi: 10.3390/nu11112778
Carmelinda Ruggiero,1,* Marta Baroni,1 Vittorio Bini,2 Annalisa Brozzetti,2 Luca Parretti,1 Elisa Zengarini,3 Maria Lapenna,1 Pierluigi Antinolfi,4 Alberto Falorni,2 Patrizia Mecocci,1 and Virginia Boccardi1



  1. Calcifediol (for humans) is far more expensive than standard Vitamin D
  2. Calcifediol is typically only available by prescripttion
  3. Many other studies consider Calcifediol potency to be 2X to 5X that of Vitamin D
  4. Chart below appears to indicate response time for both is about one month
    • Many other studies find that it takes 3-6 months for all responses to plateau
  5. Calcifediol is popular for.supplementing farm animals
  6. Calcifediol =Calcidiol)

Getting Vitamin D into your body has the following chart


 Download the PDF from VitaminDWiki

Note: Same 150 micrograms was given to both groups
150 micrograms of Vitamin D = 6,000 IU

iPTH Response ( lower is better)
Vitamin D inadequacy is pervasive in the oldest-old. Many vitamin D metabolites are available for supplementation, their effects on the recovery of adequate serum levels remain unknown. We investigate the effects of supplementation with cholecalciferol (D3) and calcifediol (25D3) on serum levels of 25(OH)D, 1-25(OH)D, bone and inflammatory markers, ultimately identifying clinical predictors of successful treatment.

Sixty-seven oldest-old individuals were randomized to weekly administration of 150 mcg of 25D3 or D3, from hospital admission to 7 months after discharge. Supplementation of 25D3 and D3 were associated with increasing serum levels of 25(OH)D (p < 0.001) and 1-25(OH)D (p = 0.01).

Participants on 25D3 experienced a steeper rise than those on D3 (group*time interaction p = 0.01), after adjustment for intact parathyroid hormone (iPTH) levels the differences disappeared (intervention*iPTH interaction p = 0.04).

Vitamin D supplementation was associated with a decreasing trend of iPTH and C-reactive protein (CRP) (p < 0.001). Polypharmacy and low handgrip strength were predictors of failure of intervention, independent of vitamin D metabolites.

In conclusion, D3 and 25D3 supplementation significantly increase vitamin D serum levels in the oldest-old individuals, with a tendency of 25D3 to show a faster recovery of acceptable iPTH levels than D3. Polypharmacy and low muscle strength weaken the recovery of adequate vitamin D serum levels.

Created by admin. Last Modification: Saturday April 24, 2021 12:58:41 GMT-0000 by admin. (Version 6)

Attached files

ID Name Comment Uploaded Size Downloads
14892 iPTH response.jpg admin 21 Jan, 2021 50.75 Kb 277
14891 weekly response 2 types.jpg admin 21 Jan, 2021 52.06 Kb 300
14890 Effects of Weekly Supplementation.pdf admin 21 Jan, 2021 1.89 Mb 362