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Liver transplant needs Vitamin D (actually semi-activated, not regular) – May 2017

Nutritional Vitamin D in Renal Transplant Patients: Speculations and Reality

Nutrients 2017, 9(6), 550; doi:10.3390/nu9060550
Piergiorgio Messa 1,2,* , Anna Regalia 2 and Carlo Maria Alfieri 1
1 Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milano 20122, Italy
2 via Festa del Perdono, Università degli Studi di Milano, Milano 20122, Italy

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The medical community is still amazed that regular vitamin D does not help poor livers
Regular vitamin D is semi-acivated by the liver into Calcidiol, so if poor liver, little Calcidiol
Need to add Calcidiol, not regular vitamin D, when the liver is not functioning well

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Reduced levels of nutritional vitamin D are commonly observed in most chronic kidney disease (CKD) patients and particularly in patients who have received a kidney transplant (KTx). In the complex clinical scenario characterizing the recipients of a renal graft, nutritional vitamin D deficiency has been put in relation not only to the changes of mineral and bone metabolism (MBM) after KTx, but also to most of the medical complications which burden KTx patients. In fact, referring to its alleged pleiotropic (non-MBM related) activities, vitamin D has been claimed to play some role in the occurrence of cardiovascular, metabolic, immunologic, neoplastic and infectious complications commonly observed in KTx recipients. Furthermore, low nutritional vitamin D levels have also been connected with graft dysfunction occurrence and progression. In this review, we will discuss the purported and the demonstrated effects of native vitamin D deficiency/insufficiency in most of the above mentioned fields, dealing separately with the MBM-related and the pleiotropic effects.


Created by admin. Last Modification: Wednesday March 24, 2021 09:48:49 GMT-0000 by admin. (Version 8)

Attached files

ID Name Comment Uploaded Size Downloads
8024 Renal Transplant.pdf PDF 2017 admin 27 May, 2017 15:31 953.32 Kb 372
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