Calcidiol (bacterial fermentation-derived vitamin D) OK with pigs (perhaps lower cost) - Aug 2022

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Efficacy and safety of a novel source of dietary 25-hydroxycholecalciferol in growing pigs

J Anim Sci . 2022 Aug 12;skac260. doi: 10.1093/jas/skac260. PDF behind $39 paywall
Jorge L Sandoval 1 , Diego E Ventura 1 , Orlando B Fiallos 1 , Brian L Anderson 2 , J Chris Sparks 3 , Jessica D Starkey 1 , Charles W Starkey 1

A randomized complete block design experiment was conducted to determine the safety and efficacy of supplementation of increasing concentrations of a novel, bacterial fermentation-derived vitamin D source on growth performance and tissue deposition of 25-hydroxycholecalciferol (25OHD3) in growing swine. Dietary treatments were as follows: commercial control with vitamin D3 (CON) at NRC recommended concentrations and 3 diets composed of CON + increasing inclusions (25, 50, and 250 µg/kg equivalent) of 25OHD3 from a novel source (CON+25; CON+50; and CON+250 respectively).

Pigs (n = 144) were assigned to 24 pens which were allotted to 1 of the 4 dietary treatments and fed for 42 d. Blood samples were collected for 25OHD3 concentration determination and individual body weights were measured on experimental d 0, 39, and 63. On d 42, tissues from 48 pigs (12 pigs per dietary treatment) were analyzed for 25OHD3 concentration. No differences were observed in growth performance. Day 39 serum 25OHD3 concentrations were greatest in CON+250-fed pigs and linearly decreased as dietary 25OHD3 inclusion decreased (P < 0.0001). On d 42, tissue 25OHD3 concentrations increased linearly as 25OHD3 increased in the diet (P < 0.0001). On d 63, 21 d after dietary 25OHD3 withdrawal, serum 25OHD3 concentrations of all 25OHD3-fed pigs decreased to that of or within 2.76 ± 0.89 ng/mL of CON-fed pigs which demonstrates that feeding 250 µg/kg 25OHD3 is well tolerated by growing pigs and will clear the body within 21 d.

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VitaminDWiki - Calcidiol category contains

48 items in Calcidiol category

Calcidiol = Calcifediol = 25-hydroxyvitamin D3 = 25(OH)D = semi-activated Vitamin D
See also

• Calcifediol (Calcidiol, semiactivated Vitamin D) - many studies 55 as of Jan 2024
• Tests for Vitamin D 160 items
• Calcitriol 62 items
• Injection 65 items
• Forms of Vitamin D 113 items
• Response to Vitamin D - many studies 186 as of June 2024
• Calcidiol is now available on Amazon
  (~7X more expensive than standard Vitamin D)
• Nanoemulsion Vitamin D is faster and better - many studies
  • Response to Nanoemulstion Vitamin D swished in the mouth appears to start in 2 hours
• Calcidiol - daily dose has fast response, but weekly might be better - March 2018

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VitaminDWiki - 6 studies in both categories Veterinary and Calcidiol

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