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Calcidiol

33 items in Calcidiol category

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Calcidiol = 25-hydroxyvitamin D3 = 25(OH)D = Calcifediol (Wikipedia)

  • Calcidiol is semi-activated Vitamin D
  • Semi-activation is accomplished by enzymes: CYP2A1 in liver and/or CYP2R1 in cells
  • Calcidiol is also available as a drug, an herb, and from eggs and meat
  • Calcidiol become fully activated into Calcitriol by CYP27B1 enzymes in Kidney and/or tissues
          (More Calcidiol info below this box)

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Here are the main Calcidiol articles


Calcidiol is available only by prescription and is expensive

Thirty 25ug capsules for $21
If you believe that calcidiol is 4X more potent than Vitamin D then each capsule has the equivalent of
   4,000 (4 X 40 X 25) IUs of vitamin D.
The cost of 4,000 IUs of vitamin D is about 2 cents
The cost of calcitriol is thus approximately 35 X more than Vitamin D3 (21/30)/0.02


Calcidiol - daily dose has fast response, but weekly might be better - March 2018

Correction of vitamin D status by calcidiol: pharmacokinetic profile, safety, and biochemical effects on bone and mineral metabolism of daily and weekly dosage regimens.
Osteoporos Int. 2017 Nov;28(11):3239-3249. doi: 10.1007/s00198-017-4180-3. Epub 2017 Aug 16.
Minisola S1, Cianferotti L2, Biondi P1, Cipriani C1, Fossi C2, Franceschelli F2, Giusti F2, Leoncini G2, Pepe J1, Bischoff-Ferrari HA3, Brandi ML4.

 Download the PDF from VitaminDWiki
Daily high dose raised blood levels quickly
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FGF23 - similar large daily dose and weekly dose
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1,25 similar response to all treatments
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Least Calcium lost in Urine = weekly
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RATIONALE: Calcidiol can be employed to correct vitamin D deficiency.

MAIN RESULTS: Calcidiol administered at daily and weekly regimens over a period of 3 months was able to successfully raise 25-hydroxyvitamin D levels without altering other markers related to bone and mineral metabolism.

SIGNIFICANCE: Calcidiol supplementation is effective and safe.

INTRODUCTION:
The correction of vitamin D status is necessary to maintain an optimal mineral and skeletal homeostasis. Despite cholecalciferol (vitamin D3) is the most commonly used drug for vitamin D supplementation, the more hydrophilic compound calcidiol (25-hydroxyvitamin D3) can be employed at daily, weekly, and monthly regimens to reach in the short term the target levels of serum 25-hydroxyvitamin D [25(OH)D]. In the administration of different doses of calcidiol pharmacokinetic study (ADDI-D study), the efficacy and safety of daily and weekly dosages of calcidiol were tested.

METHODS:
A total of 87 Caucasian, community-dwelling, postmenopausal women, aged 55 years or older, with vitamin D inadequacy (serum 25(OH)D levels <30 ng/ml, with mean 25(OH)D below 20 ng/ml, namely 16.5 ± 7.5 ng/ml) were randomized to receive three different dosages of calcidiol: 20 μg/day, 40 μg/day, and 125 μg/week for 3 months. The attained level of serum 25(OH)D was selected as primary endpoint to assess efficacy, while other parameters of mineral metabolism, (serum calcium, parathyroid hormone, phosphate, FGF23, urinary calcium, and markers of bone turnover) were assessed as secondary endpoints to establish safety.

RESULTS:
In all the three groups, serum 25(OH)D values significantly and promptly rose and plateaued above the 30 ng/ml threshold remaining within safety interval after 14 days of treatment, with similar efficacy for the similar daily and weekly dose regimens. The different dosages were also equally effective in controlling secondary hyperparathyroidism. No significant changes in calcium and phosphate metabolism and in bone turnover markers were observed for any of the treatments, confirming the safety of this compound.

CONCLUSIONS:
The results of this study demonstrate the short- and mid-term efficacy and safety on core parameters of mineral metabolism of different daily or weekly dosages of calcidiol when used to treat vitamin D inadequacy or deficiency in postmenopausal women. Further studies are needed to assess falls as primary outcome of calcidiol supplementation.

PMID: 28815282 DOI: 10.1007/s00198-017-4180-3


Is calcifediol better than cholecalciferol for vitamin D supplementation?

Osteoporosis International (2018) 29:1697–1711 May 2018 https://doi.org/10.1007/s00198-018-4520-y
J. M. Quesada-Gomez1,2 & R. Bouillon3
 Download the PDF from Sci-hub via VitaminDWiki


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Created by admin. Last Modification: Tuesday May 25, 2021 11:33:11 GMT-0000 by admin. (Version 44)

Attached files

ID Name Comment Uploaded Size Downloads
15635 which is better - sci-hub.pdf admin 25 May, 2021 11:18 647.59 Kb 80
14958 map_pin_icon.png oregional 31 Jan, 2021 22:16 1.08 Kb 68
9487 Caclium in urine.jpg admin 10 Mar, 2018 16:32 19.71 Kb 1669
9485 calcidiol 1,25 daily weekl.jpg admin 10 Mar, 2018 16:19 14.36 Kb 1688
9483 calcidiol daily weekl.jpg admin 10 Mar, 2018 16:17 32.22 Kb 1748
9482 Calcidiol FGF23.jpg admin 10 Mar, 2018 16:17 14.29 Kb 1667
9481 calcidiol daily weekly.pdf PDF 2018 admin 10 Mar, 2018 16:16 921.11 Kb 875
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