Effects of Weekly Supplementation of Cholecalciferol and Calcifediol Among the Oldest-Old People: Findings From a Randomized Pragmatic Clinical Trial
Nutrients. 2019 Nov; 11(11): 2778. online 2019 Nov 15. doi: 10.3390/nu11112778
Carmelinda Ruggiero,1,* Marta Baroni,1 Vittorio Bini,2 Annalisa Brozzetti,2 Luca Parretti,1 Elisa Zengarini,3 Maria Lapenna,1 Pierluigi Antinolfi,4 Alberto Falorni,2 Patrizia Mecocci,1 and Virginia Boccardi1
- Calcifediol (for humans) is far more expensive than standard Vitamin D
- Calcifediol is typically only available by prescripttion
- Many other studies consider Calcifediol potency to be 2X to 5X that of Vitamin D
- Chart below appears to indicate response time for both is about one month
- Many other studies find that it takes 3-6 months for all responses to plateau
- Calcifediol is popular for.supplementing farm animals
- Calcifediol =Calcidiol)
- Calcidiol category listing has
33 items along with related searches
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- Calcifediol (Calcidiol) might be a better form of Vitamin D for some people – May 2019
- COVID-19 defeated by calcifediol form of Vitamin D in Spain - pilot RCT Aug 29, 2020
- Oral calcidiol is a good form of vitamin D supplementation – Aug 2017
- Is HyD (25(OH)D) a better form of vitamin D for some animals and maybe humans with liver problems
Getting Vitamin D into your body has the following chart
Note: Same 150 micrograms was given to both groups
150 micrograms of Vitamin D = 6,000 IU
iPTH Response ( lower is better)
Vitamin D inadequacy is pervasive in the oldest-old. Many vitamin D metabolites are available for supplementation, their effects on the recovery of adequate serum levels remain unknown. We investigate the effects of supplementation with cholecalciferol (D3) and calcifediol (25D3) on serum levels of 25(OH)D, 1-25(OH)D, bone and inflammatory markers, ultimately identifying clinical predictors of successful treatment.
Sixty-seven oldest-old individuals were randomized to weekly administration of 150 mcg of 25D3 or D3, from hospital admission to 7 months after discharge. Supplementation of 25D3 and D3 were associated with increasing serum levels of 25(OH)D (p < 0.001) and 1-25(OH)D (p = 0.01).
Participants on 25D3 experienced a steeper rise than those on D3 (group*time interaction p = 0.01), after adjustment for intact parathyroid hormone (iPTH) levels the differences disappeared (intervention*iPTH interaction p = 0.04).
Vitamin D supplementation was associated with a decreasing trend of iPTH and C-reactive protein (CRP) (p < 0.001). Polypharmacy and low handgrip strength were predictors of failure of intervention, independent of vitamin D metabolites.
In conclusion, D3 and 25D3 supplementation significantly increase vitamin D serum levels in the oldest-old individuals, with a tendency of 25D3 to show a faster recovery of acceptable iPTH levels than D3. Polypharmacy and low muscle strength weaken the recovery of adequate vitamin D serum levels.Weekly response to semi-activated vitamin D slightly better than standard – RCT Nov 2019
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