Loading...
 
Toggle Health Problems and D

COVID-19 defeated by calcifediol form of Vitamin D in Spain - pilot RCT Aug 29, 2020

Effect of Calcifediol Treatment and best Available Therapy versus best Available Therapy on Intensive Care Unit Admission and Mortality Among Patients Hospitalized for COVID- 19: A Pilot Randomized Clinical study

To appear in: Journal of Steroid Biochemistry and Molecular Biology
https://doi.org/10.1016/j.jsbmb.2020.105751

Dr. Grant's summary of the trial
The results of treatment of COVID-19 patients in Spain with calcifediol were announced on August 29. (Calcifediol [25(OH)D] is often used in Spain. They state that the conversion factor for calcifediol is 3.2 times the same mass as cholecalciferol Thus, the 0.532 mg of calcifediol is equivalent to 64,240 IU of cholecalciferol.) The mean age of the patients was 53±10 years. None of the prognostic factors evaluated except previous high blood pressure (15 without treatment, 11 with treatment) significantly affected the outcome. In this study, 50 patients were given soft capsules of 0.532 mg calcifediol on the day of admission, then on day 3 and seven, then weekly until discharge or admission to the intensive care unit (ICU). Forty nine of the caldifediol-treated patients did not require the ICU, while 13 of the 26 not receiving that treatment did require the ICU. While this was a pilot RCT, it provides strong evidence that vitamin D treatment can reduce the risk of adverse COVID-19 outcome.
- - - - - - - - - - - - - -
First two weeks: (532+266+266+266) ug X 40 IU/ug X 3.2 = 53,200 IU X 3.2 = 172,000 IU equiv. of Vitamin D3

 Download the trial PDF from VitaminDWiki


Grassroots Health chart of the trial
Image


Dr. von Helden's chart of the trial
Note: 20,000 seems incorrect
Image


Chris Masterjohn


The First Clinical Trial to Support Vitamin D Therapy For Covid-19 Sept 4
"Calcifediol is also 3.2-fold more effective than native vitamin D3 supplements in restoring low blood levels of vitamin D3. Because normal vitamin D3 needs to undergo liver processing first, which is not required for calcifediol. Another perk of calcifediol is its higher intestinal absorption rate."

    • Note by VitaminDWiki: nanoemulsion Vitamin D appears to also have a high absorption rate, and can be applied topically or inside the mouth for very fast absorption without the use of the intestine

VitaminDWiki

The pilot trial on this page is the first of many Randomized Clinical Trials in the pipeline

Note: Several RCTs in the past 5 years were terminated when the Vitamin D was found to have saved dramatically more lives than the placebo. Unfortunately, the medical community ignored the trials which did not finish. Wonder if some RCT's for Vitamin D and COVID-19 will be similarly stopped and ignored

Intervention Trial Summary Table
COVID-19 RCTs

Including the one RCT which was pilot tested: #17

Getting Vitamin D into your body

has a chart which shows Calcidiol, the form used by this trial
http://vitamindwiki.com/tiki-index.php?page_id=5644


50 most-recently changed items in Virus category in VitaminDWiki

Id Page Hits Last modification Creator Categories
12238 Vitamin D, COVID - Campbell and Davies (UK with transcript) - Jan 18, 2021 46
19 Jan, 2021 13:42
admin Books, videos on Vitamin D
Virus
12067 Governments are starting to use vitamin D to fight COVID-19 866
19 Jan, 2021 12:25
admin Virus
11728 COVID-19 treated by Vitamin D - studies, reports, videos 24889
19 Jan, 2021 12:01
admin Top news
Virus
12235 Iranians with COVID-19 were 2.3 X more likely to die if low vitamin D – Jan 2021 156
18 Jan, 2021 03:37
admin Mortality and D
Virus
12234 .Iranians with COVID-19 were 2.3 X more likely to die if low vitamin D – Jan 2021 11
18 Jan, 2021 03:22
admin Mortality and D
Virus
12233 Vitamin D to prevent COVID- strange trial recommendations from the UK – Jan 2021 70
18 Jan, 2021 03:11
admin Virus
12232 400,000 COVID deaths, 400,000 IUs of Vitamin D needed to prevent COVID death - Jan 2021 78
17 Jan, 2021 23:03
admin Virus
12229 Many COVID-19 risks are associated with low vitamin D (7 studies) – Systematic Review Jan 2021 84
16 Jan, 2021 18:05
admin Virus
12227 40 ng of Vitamin D to fight COVID 15K to 50K weekly or 100K monthly – Spanish Jan 2021 87
16 Jan, 2021 11:23
admin Virus
12213 30 x fewer COVID-19 deaths in those getting 400,000 IU of Vitamin D - Jan 2021 382
15 Jan, 2021 16:23
admin Mortality and D
Virus
11959 Admission to COVID-19 ICU 1.7X more likely to have less than 20 ng of vitamin D – Sept 2020 235
15 Jan, 2021 14:07
admin Virus
12223 Herd immunity occurs only via vaccination - W.H.O. Oct 2020 56
15 Jan, 2021 14:04
admin Virus
12043 COVID-19 survivors can have poor health for a long time 187
14 Jan, 2021 20:40
admin Virus
12221 Poor COVID-19 prognosis was 6 X more likely if low vitamin D – Jan 21, 2021 174
13 Jan, 2021 21:04
admin Mortality and D
Virus
12220 4X fewer COVID-19 deaths in those having high Omega-3 index – Jan 6, 2021 95
13 Jan, 2021 20:38
admin Vitamin D and Omega-3
Virus
11703 Coronavirus might hitch a ride on air pollution - March 2020 810
13 Jan, 2021 01:01
admin Virus
12219 COVID-19 cases in Delhi increased 7 days after pollution (less UV and Vitamin D, indoors more) Jan 12, 2021 64
13 Jan, 2021 00:51
admin Virus
12195 Vitamin D reduces COVID-19 by 80 percent - anonymous meta-analysis - Jan 5, 2021 489
13 Jan, 2021 00:20
admin Meta-analysis of Vitamin D
Virus
12216 Many increased risks for dying of COVID-19 in nursing home (Vitamin D not even mentioned) - Jan 6 2021 42
11 Jan, 2021 23:36
admin Virus
12217 Active vitamin D (calcitriol) might fight COVID-19 – Jan 5, 2021 83
11 Jan, 2021 23:28
admin Calcitriol
Virus
12215 Vitamin D sales up 40 percent in Dec (2020 vs 2019) 109
11 Jan, 2021 20:03
admin Virus
12210 2.8 X fewer COVID-19 nursing home deaths if add 10,000 IU Vitamin D daily for a week (small observation)- Jan 2021 222
10 Jan, 2021 21:04
admin Mortality and D
Virus
12197 Don’t Let COVID-19 Patients Die With Vitamin D Deficiency - Jan 5, 2021 415
10 Jan, 2021 20:14
admin Virus
12035 COVID-19 lung death 4X more likely in Iran if less than 25 ng of vitamin D – Oct 30, 2020 569
10 Jan, 2021 04:29
admin Breathing
Mortality and D
Virus
11945 14.7 X more likely to die of COVID-19 if less than 12 ng of Vitamin D (185 Germans) – Sept 10, 2020 928
10 Jan, 2021 04:28
admin Mortality and D
Virus
11901 COVID ARDS deaths 2X more likely if less than 10 ng of Vitamin D – Aug 8, 2020 555
10 Jan, 2021 04:28
admin Breathing
Mortality and D
Virus
12010 9X COVID-19 survival in nursing home if had 80,000 IU dose of vitamin D in previous month – Oct 2020 1522
10 Jan, 2021 04:25
admin Mortality and D
Virus
12073 Hospital COVID-19 observation: 7X more likely to live if more than 20 ng of vitamin D– Nov 19, 2020 767
10 Jan, 2021 04:22
admin Mortality and D
Middle East
Virus
12090 COVID-19 male mortality increased 3.9 X if low vitamin D – observation Nov 25, 2020 184
10 Jan, 2021 04:21
admin Mortality and D
Virus
12145 7X less likely to die of COVID-19 if taking Vitamin D loading dose – Dec 11, 2020 699
10 Jan, 2021 04:20
admin Mortality and D
Loading dose for Vitamin D
Virus
12190 Italian nursing home COVID-19 – 4X less likely to die if taking Vitamin D– Dec 22, 2020 236
10 Jan, 2021 04:19
admin Mortality and D
Virus
12207 COVID-19 Disease and Vitamin D: A Mini-Review – Dec 15, 2020 114
09 Jan, 2021 10:40
admin Virus
12206 6 months after COVID-19 hospitalization 76 percent still had at least one symptom – Jan 8, 2021 100
09 Jan, 2021 03:26
admin Virus
11925 Long term fatigue, etc. common after viral infections (SARS1,2, MERS, Swine, 1918,...) 564
09 Jan, 2021 02:55
admin Virus
12162 600,000 IU of Vitamin D (total) allowed previously weak immune systems to fight off a virus antigen - Nov 2020 254
08 Jan, 2021 16:24
admin Seniors
Immunity
Virus
12202 Small study found Vitamin D did not fight COVID-19 (probably mostly less than 30 ng) – Jan 2020 120
07 Jan, 2021 17:05
admin Virus
12198 COVID-19 test positive 4.5 X more likely if had low vitamin D test within 4 years – Jan 6, 2021 181
06 Jan, 2021 20:51
admin Virus
12196 Less likely to test positive for COVID-19 if higher Vitamin D – meta-analysis Jan 6, 2021 250
06 Jan, 2021 12:05
admin Meta-analysis of Vitamin D
Virus
11865 Health problems at high risk of COVID-19 665
05 Jan, 2021 21:33
admin Virus
12146 Excellent on-going analysis of Vitamin D and COVID-19 publications 366
05 Jan, 2021 19:03
admin Virus
12050 Vitamin D fighting COVID-19 meets all Bradford Hill Criteria - Nov 2020 590
05 Jan, 2021 14:03
admin Virus
11819 Hill's Criteria indicates that COVID-19 will be treated by Vitamin D - Annweiler June 8 2020 781
05 Jan, 2021 13:59
admin Virus
12194 COVID 19 Video - Drs. Seheult and Campbell : Lessons Learned and a Look Ahead - Jan 4 225
04 Jan, 2021 21:02
admin Books, videos on Vitamin D
Virus
12168 CDC listed health problems at increased risk of COVID-19 (all are associated with low Vitamin D) - Dec 1, 2020 217
04 Jan, 2021 17:26
admin Virus
12193 Many drugs increase ACE2 and COVID-19 (176 page review) - Dec 2020 188
04 Jan, 2021 17:23
admin Virus
12148 COVID-19 plus pneumonia in ICU with low vitamin D equaled Death - Dec 2020 254
04 Jan, 2021 15:36
admin Virus
12180 400 IU Vitamin D for UK adults with COVID is based on a RTI study biased by infants - Jan 2021 191
29 Dec, 2020 13:20
admin Virus
12161 Take 50,000 IU of Vitamin D weekly before and after COVID-19 vaccination 503
27 Dec, 2020 14:12
admin Virus
6630 Influenza prevented by 40 ng levels or treated with vitamin D hammer (50,000 IU) – June 2015 13876
26 Dec, 2020 21:59
admin Intervention
Vitamin D in Canada
Virus
12142 COVID-19 Vitamin D: Overview by Dr. in Sri Lanka (Video and transcript) - Dec 8, 2020 722
26 Dec, 2020 20:55
admin Books, videos on Vitamin D
Loading dose for Vitamin D
Virus
Title change made Nov 2020 caused the visitor count to reset.
There have actually been 1779 visitors to this page since it was originally made


Created by admin. Last Modification: Sunday November 22, 2020 22:34:11 GMT-0000 by admin. (Version 19)

Attached files

ID Name Comment Uploaded Size Downloads
14288 Castillo Helden 2.jpg admin 08 Sep, 2020 16:32 227.96 Kb 928
14285 Effect of Calcifediol Treatment Spanish pilot test.pdf PDF 2020 admin 08 Sep, 2020 01:18 237.80 Kb 132
14284 Castillo GRH.jpg admin 08 Sep, 2020 01:18 86.32 Kb 1020
See any problem with this page? Report it (FINALLY WORKS)