Impact of the 25-Hydroxycholecalciferol Concentration and Vitamin D Deficiency Treatment on Changes in the Bone Level at the Implant Site during the Process of Osseointegration: A Prospective, Randomized, Controlled Clinical Trial
J. Clin. Med. 2021, 10(3), 526; https://doi.org/10.3390/jcm10030526
by Jakub Kwiatek †,Aleksandra Jaroń †OrcID andGrzegorz Trybek *OrcID
Department of Oral Surgery, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72/18, 70-111 Szczecin, Poland
Group A <30 ng of Vitamin D, not supplemented
Group B <30 ng of Vitamin D and supplemented for weeks before surgery
Group C ~40ng of vitamin D
Relevant Dental in VitaminDWiki
- Dental implants more successful if higher level of vitamin D – Sept 2016
- Dental implant failure 4 times more likely if low vitamin D (not statistically significant) – Sept 2016
- American Dental Association, like the AMA, follows the money not the science – March 2019
- 1.8 X more likely to have additional Dental Implant Failure if poor Vitamin D Receptor – Dec 2019
- Dental implants 10 percent better with topical vitamin D (in dogs) – Sept 2015
- Bone implants aided by Vitamin D in 80 percent of studies, conclusion – more studies needed – Feb 2016
- Higher level of vitamin D improved dental health in many ways
Bone growth improved even more if add more than just Vitamin D
- Hypothesis: increased bone mineral density needs protein, Ca, Mg, Vitamin D and K
- Magnesium increases Vitamin D, which increases Mg. Both increase bone – Oct 2019
- Adding just vitamin D again failed to add bone density (also need Magnesium, Vitamin K, etc) – RCT Aug 2018
- Bone increased : Stiffness (Vitamin D), Flexibility (Vitamin K2) – Sept 2020
- Suspect that flxibility is important for teeth as well
- Bone quality improved 2X by Vitamin D plus Vitamin K2 (trend) – meta-analysis March 2020
- Vitamin D and Calcium do not increase bone density (also need exercise, Mg, K2, protein etc.) – RCT Aug 2019
- Bone formation in the lab is aided by Vitamin D, Vitamin K1, and Vitamin K2 – meta-analysis Nov 2017
Introduction: The most important factor which is responsible for the positive course of implant treatment is the process of osseointegration between the implant structure and the host’s bone tissue. The aim of this study was to assess what effect the 25-hydroxycholecalciferol concentration and vitamin D deficiency treatment have on changes in the bone level at the implant site during the process of osseointegration in the mandible.
Materials and Methods: The study was with 122 people qualified for implant surgery, who were assigned to three research groups (A, B, and C). Laboratory, clinical, and radiological tests were performed on the day of surgery, and after 6 and 12 weeks. The bone level in the immediate proximity of the implant was determined by radiovisiography (RVG).
Results: The bone level after 12 weeks in Groups B and C was significantly higher than after 6 weeks. The bone level in the study Group B was significantly higher than in Group A. The study showed that the higher the levels of 25-hydroxycholecalciferol were observed on the day of surgery, the higher was the level of bone surrounding the implant after 6 and 12 after surgery.
Conclusion: The correct level of 25-hydroxycholecalciferol on the day of surgery and vitamin D deficiency treatment significantly increase the bone level at the implant site in the process of radiologically assessed osseointegration.