Bone Microstructure in Response to Vitamin D3 Supplementation: A Randomized Placebo-Controlled Trial
Calcified Tissue International, pp 1–11 https://doi.org/10.1007/s00223-018-0481-6
Lise Sofie Bislev, Lene Langagergaard Rødbro Lars Rolighed Tanja Sikjaer Lars Rejnmark
81 postmenopausal women with Vitamin D levels < 20 ng
spine areal BMD (aBMD) or volumetric BMD (vBMD) are surrogates of bone strength
BMD is easliy measured (by DXA), but Bone Strength is what is important
- Vitamin D not help fractures and falls if not vitamin D deficient – meta-analysis Oct 2018
- Fractures not reduced by small amounts of vitamin D - meta-analysis Dec 2017
- Preventing Falls in Older Adults – Vitamin D combination is the best - JAMA Meta-analysis Nov 2017
- Hip fracture 58 percent more likely if low vitamin D – meta-analysis March 2017
- Vitamin D prevents falls – majority of meta-analyses conclude – meta-meta analysis Feb 2015
- Vitamin D and fractures – 24 meta-analyses and counting – Dec 2014
- Countries which have increased Vitamin D have decreased bone problems (Japan, Australia)
Strong bones often need more than just vitamin D
- Healthy bones need: Calcium, Vitamin D, Magnesium, Silicon, Vitamin K, and Boron – 2012
- Bone formation in the lab is aided by Vitamin D, Vitamin K1, and Vitamin K2 – meta-analysis Nov 2017
- Bone density improved with resveratrol (which improves Vitamin D Receptor) – RCT Sept 2018
- Resveratrol gets more vitamin D to the cells, without raising measure vitamin D levels
- Postmenopausal women need Vitamin D, protein and exercise to prevent loss of muscle and bone – Aug 2018
- Adding just vitamin D again failed to add bone density (also need Magnesium, Vitamin K, etc) – RCT Aug 2018
- Vitamin K-2 (180 ug MK-7) helped both bone density and strength – RCT March 2013
- Bone strength (more accurate than BMD) is inversely associated with vitamin D level – May 2015
40+ ng of Vitamin D is better than 30-40 ng
- 4X fewer stress fractures in college athletes if more than 40 ng of vitamin D – Feb 2016
- Falls reduced by a third if achieved 40 ng level vitamin D– RCT Sept 2018
Falls and Fractures category contains the following summary
258 items in FALLS and FRACTURES - Vitamin D and Calcium cost-effectively reduce falls and fractures – April 2019
- see also Overview Seniors and Vitamin D
Falls
- Fall prevention - Vitamin D is one of the ways - umbrella review Jan 2024
- Deaths due to falls doubled in just a decade (age-adjusted, perhaps decreased vitamin D) – June 2019
- Preventing Falls in Older Adults – Vitamin D combination is the best - JAMA Meta-analysis Nov 2017
- Falls cut in half by 100,000 IU vitamin D monthly - RCT 2016
- Falls reduced by a third if achieved 40 ng level vitamin D– RCT Sept 2018
- Note: It took 6 months to get to that level. Most trials last only 3 months
- Vitamin D prevents falls – majority of meta-analyses conclude – meta-meta analysis Feb 2015
- Falls reduced by Vitamin D: 13 percent reduction if more than 700 IU – review of 38 trials – Aug 2022
Fracture
- Hip fractures are predicted by 10 factors – low Vitamin D is the biggest – Aug 2023
- Vitamin D and fractures – 24 meta-analyses and counting – Dec 2014
- Low trauma bone fractures in seniors – considering Vitamin D loading dose for all, without testing – Nov 2019
- Vitamin K (any amount and any kind) reduced bone fractures by 24 percent – meta-analysis – May 2019
- 75+ Hip fracture items in VitaminDWiki title Click here for details
PDF is available free at Sci-Hub 10.1007/s00223-018-0481-6
Vitamin D supplementation is often used in the prevention and treatment of osteoporosis, but the role of vitamin D has lately been questioned. We aimed to investigate the effect of 3 months of daily vitamin D3 supplementation (70 µg [2800 IU] vs. placebo) initiated in winter months on bone health. This study is a double-blinded placebo-controlled randomized trial. Bone health was assessed by bone turnover markers, DXA, HRpQCT, and QCT scans. The participants were 81 healthy postmenopausal women with low 25(OH)D (< 50 nmol/l) and high PTH levels (> 6.9 pmol/l) at screening. Vitamin D3 supplementation significantly increased levels of 25(OH)D and 1,25(OH)2D by 59 nmol/l and 19 pmol/l, respectively, whereas PTH was reduced by 0.7 pmol/l (all p < 0.0001).
Compared with placebo, vitamin D3 did not affect bone turnover markers, aBMD by DXA or trabecular bone score.
Vitamin D3 increased trabecular vBMD (QCT scans) in the trochanter region (0.4 vs. − 0.7 g/cm3) and the femoral neck (2.1 vs. − 1.8 g/cm3) pall < 0.05. HRpQCT scans of the distal tibia showed reduced trabecular number (− 0.03 vs. 0.05 mm−1) and increased trabecular thickness (0.001 vs. − 0.005 mm), as well as an improved estimated bone strength as assessed by failure load (0.1 vs. − 0.1 kN), and stiffness (2.3 vs. − 3.1 kN/mm pall ≤ 0.01).
Changes in 25(OH)D correlated significantly with changes in- trabecular thickness,
- stiffness, and
- failure load.
Three months of vitamin D3 supplementation improved bone strength and trabecular thickness in tibia, vBMD in the trochanter and femoral neck, but did not affect aBMD.
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Bone STRENGTH improved by 2800 IU of Vitamin D (not bone density) – RCT Oct 20188717 visitors, last modified 08 Oct, 2018, This page is in the following categories (# of items in each category)