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Diagnosis and treatment of osteopenia – Holick 2010

Rev Endocr Metab Disord. 2010 Dec;11(4):237-51. doi: 10.1007/s11154-010-9154-0.
Karaguzel G1, Holick MF.


A good sign of low vitamin D is when 2 out of 3 bones hurt when pressed
   (breastbone, left shin, right shin)
Want to catch and stop or reverse Osteopenia before it becomes Osteoporosis
It is very difficult (impossible?) to reverse Osteoporosis - by then too many "bone bridges" are gone
Magnesium is removed by water softeners

  • "Soft water" is free from dissolved salts of such metals as calcium, iron, or magnesium, which form insoluble deposits such as appear as scale in boilers or soap curds in bathtubs and laundry equipment.
  • "A typical residential ion-exchange water softener softens hard water by exchanging calcium and magnesium for sodium"
    • A quick search of the web was unable to find how much Magnesium is removed: 50%, 80 %, 90%?
  • Reverse osmosis removes 93-99% of all Magnesium and Calcium

Building bone takes more than just Vitamin D


Magnesium and Vitamin D contains the following summary

354 items in category, see also

Mg and Vitamin D

Dr. Dean

Number of studies in both of the categories of Magnesium and:

Bone 16,  Cardiovascular 17,   Diabetes 28. Depression 14,  Obesity 11,   Omega-3 36,  Zinc 24,  Pregnancy 11,  Headache 11,   Virus 26,   Calcium 27   Virus 26   Mortality 9   Hypertension 12   Inflammation 3   Pain 7 etc.

Overview Osteoporosis and vitamin D contains the following summary

  • FACT: Bones need Calcium (this has been known for a very long time)
  • FACT: Vitamin D improves Calcium bioavailability (3X ?)
  • FACT: Should not take > 750 mg of Calcium if taking lots of vitamin D (Calcium becomes too bio-available)
  • FACT: Adding vitamin D via Sun, UV, or supplements increased vitamin D in the blood
  • FACT: Vitamin D supplements are very low cost
  • FACT: Many trials, studies. reviews, and meta-analysis agree: adding vitamin D reduces osteoporosis
  • FACT: Toxic level of vitamin D is about 4X higher than the amount needed to reduce osteoporosis
  • FACT: Co-factors help build bones.
  • FACT: Vitamin D Receptor can restrict Vitamin D from getting to many tissues, such as bones
  • It appears that to TREAT Osteoporosis:
  •        Calcium OR vitamin D is ok
  •        Calcium + vitamin D is good
  •        Calcium + vitamin D + other co-factors is great
  •        Low-cost Vitamin D Receptor activators sometimes may be helpful
  • CONCLUSION: To PREVENT many diseases, including Osteoporosis, as well as TREAT Osteoporosis
  • Category Osteoporosis has 217 items
  • Category Bone Health has 308 items

Note: Osteoporosis causes bones to become fragile and prone to fracture
  Osteoarthritis is a disease where damage occurs to the joints at the end of the bones

Images from the web


 Download the PDF from Sci-Hub via VitaminDWiki

Osteopenia is a term to define bone density that is not normal but also not as low as osteoporosis.
By definition from the World Health Organization osteopenia is defined by bone densitometry as a T score -1 to -2.5.
There are many causes for osteopenia including calcium and vitamin D deficiency and inactivity. Genetics plays an important role in a person's bone mineral density and often Caucasian women with a thin body habitus who are premenopausal are found to have osteopenia.

Correction of calcium and vitamin D deficiency and walking 3 to 5 miles a week can often improve bone density in the hip and spine.
There are a variety of pharmaceutical agents that have been recommended for the treatment of osteopenia and osteoporosis including hormone replacement therapy, selective estrogen receptor modulator therapy, anti-resorptive therapy. In addition patients with osteoporosis who have failed anti-resorptive therapy can have a significant improvement in their bone density with anabolic therapy.

Created by admin. Last Modification: Monday December 10, 2018 13:33:02 GMT-0000 by admin. (Version 14)

Attached files

ID Name Comment Uploaded Size Downloads
11026 Catch penia before it become porosis.jpg admin 10 Dec, 2018 48.25 Kb 8709
11025 Osteo.jpg admin 10 Dec, 2018 15.02 Kb 1288
11024 Osteopenia Holick.pdf admin 10 Dec, 2018 318.54 Kb 1176