Effect of Monthly, High‐Dose, Long‐Term Vitamin D Supplementation on Central Blood Pressure Parameters: A Randomized Controlled Trial Substudy
Journal of the American Heart Association. 2017;6:e006802. published October 24, 2017, https://doi.org/10.1161/JAHA.117.006802John D. Sluyter, Carlos A. Camargo, Alistair W. Stewart, Debbie Waayer, Carlene M. M. Lawes, Les Toop, Kay‐Tee Khaw, Simon A. McG. Thom, Bernhard Hametner, Siegfried Wassertheurer, Kim H. Parker, Alun D. Hughes, Robert Scragg
- Overview Hypertension and Vitamin D Overview
- Blood pressure in diabetics reduced by 12 weekly doses of 50,000 IU vitamin D – RCT Jan 2014
- Daily average of 3600 IU Vitamin D helped hypertensives – Jan 2013
- Stroke is 13.5 X more likely if low vitamin D and high blood pressure – March 2015
Hypertension Intervention trials using Vitamin D (any time period)
- Hypertension reduced by Magnesium plus 3,000 IU of vitamin D for 12 weeks – RCT July 2022
- A small amount of Vitamin D for a short time does not help (2800 IU, 8 weeks) – RCT Oct 2021
- Pulmonary Hypertension deaths prevented by 80 ng of Vitamin D (in rats) – July 2017
- Preeclampsia risk reduced 7X by 4,000 IU of Vitamin D daily – RCT March 2018
- Blood pressure reduced by monthly 100,000 IU of vitamin D in those who were deficient – RCT Oct 2017
- Preeclampsia recurrence reduced 2 X by 50,000 IU of vitamin D every two weeks – RCT July 2017
- Pulmonary hypertension reduced in some people with weekly 50,000 IU vitamin D for 3 months – 2016
- Preeclampsia risk reduced by higher levels of vitamin D (VDAART 4,400 IU) - RCT Nov 2016
- 2000 IU of vitamin D for just 2 weeks helped in many ways – RCT June 2016
- Preeclampsia reduced by Vitamin D (50,000 IU bi-weekly) and Calcium – Oct 2015
- Arterial stiffness reduced by a single dose of 100,000 IU of vitamin D – RCT Dec 2014
- Hypertension not reduced by adding vitamin D to patients who had enough vitamin D – RCT June 2014
- Hypertension (both systolic and diastolic) reduced with 2,000 IU of vitamin D – RCT June 2014
- Blood pressure in diabetics reduced by 12 weekly doses of 50,000 IU vitamin D – RCT Jan 2014
- 3000 IU reduced hypertension for the vitamin D insufficient – RCT Aug 2012
- Hypertension reduced 6.8 mmHg with 3,000 IU of vitamin D daily – RCT May 2012
- Systolic blood pressure reduced by vitamin D (many studies)
Similar: 50,000 IU twice a month prevented or treated the following
Diabetes + Heart Failure + Chronic Pain + Depression + Autism + Breast Cancer + Colon Cancer + Prostate Cancer + BPH (prostate) + Preeclampsia + Premature Birth + Falls + Cognitive Decline + Respiratory Tract Infection + Influenza + Tuberculosis + Chronic Obstructive Pulmonary Disease + Lupus + Inflammatory Bowel Syndrome + Urinary Tract Infection + Poor Sleep + Growing Pain + Multiple Sclerosis + PMS + Schizophrenia + Endometriosis + Smoking 27 problems
Note: Once a week also fights: COVID, Headaches, Colds, Fibromyalgia, Asthma, Hives, Colitis etc.
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Background The effects of monthly, high‐dose, long‐term (≥1‐year) vitamin D supplementation on central blood pressure (BP) parameters are unknown.
Methods and Results A total of 517 adults (58% male, aged 50–84 years) were recruited into a double‐blinded, placebo‐controlled trial substudy and randomized to receive, for 1.1 years (median; range: 0.9–1.5 years), either (1) vitamin D3 200 000 IU (initial dose) followed 1 month later by monthly 100 000‐IU doses (n=256) or (2) placebo monthly (n=261). At baseline (n=517) and follow‐up (n=380), suprasystolic oscillometry was undertaken, yielding aortic BP waveforms and hemodynamic parameters. Mean deseasonalized 25‐hydroxyvitamin D increased from 66 nmol/L (SD: 24) at baseline to 122 nmol/L (SD: 42) at follow‐up in the vitamin D group, with no change in the placebo group. Despite small, nonsignificant changes in hemodynamic parameters in the total sample (primary outcome), we observed consistently favorable changes among the 150 participants with vitamin D deficiency (<50 nmol/L) at baseline.
In this subgroup, mean changes in the vitamin D group (n=71) versus placebo group (n=79) were
- −5.3 mm Hg (95% confidence interval CI, −11.8 to 1.3) for brachial systolic BP (P=0.11),
- −2.8 mm Hg (95% CI, −6.2 to 0.7) for brachial diastolic BP (P=0.12),
- −7.5 mm Hg (95% CI, −14.4 to −0.6) for aortic systolic BP (P=0.03),
- −5.7 mm Hg (95% CI, −10.8 to −0.6) for augmentation index (P=0.03),
- −0.3 m/s (95% CI, −0.6 to −0.1) for pulse wave velocity (P=0.02),
- −8.6 mm Hg (95% CI, −15.4 to −1.9) for peak reservoir pressure (P=0.01), and
- −3.6 mm Hg (95% CI, −6.3 to −0.8) for backward pressure amplitude (P=0.01).
Conclusions Monthly, high‐dose, 1‐year vitamin D supplementation lowered central BP parameters among adults with vitamin D deficiency but not in the total sample.
Clinical Trial Registration URL: http://www.anzctr.org.au. Unique identifier: ACTRN12611000402943.