Effect of vitamin D supplementation on blood pressure parameters in patients with vitamin D deficiency: a systematic review and meta-analysis
Journal of the American Society of Hypertension, Vol 12, Issue 7, July 2018, Pages 488-496 https://doi.org/10.1016/j.jash.2018.04.009
- Blood pressure in diabetics reduced by 12 weekly doses of 50,000 IU vitamin D – RCT Jan 2014
- Pulmonary hypertension reduced in some people with weekly 50,000 IU vitamin D for 3 months – 2016
- Hypertension risk decreased 10X by increasing vitamin D levels to more than 40 ng – Nov 2017
Hypertension category listing contains the following
Overview Hypertension and vitamin D
Overview Cardiovascular and vitamin D
Overview Stroke and vitamin D
Incidence of 22 health problems related to vitamin D have doubled in a decade
160% increase per decade (women, age adjusted)
Hypertension also reduced by Magnesium
- Reduce blood pressure by 9 mm with triple hypertensive drug or 19 mm with Magnesium – April 2018
- Prehypertension risk is increased by 78% if low Magnesium – Aug 2015
Hypertension also reduced by Omega-3
- Hypertension reduced by Omega-3, especially if previously untreated – meta-analysis July 2014
- Blood pressure 4 mm lower if Omega-3 index was high – March 2018
- Hypertension nonconventional therapies: Magnesium, melatonin, Vitamin C, etc. – Jan 2018
Hypertension also reduced by Vitamin K
- Hypertension 1.7 times more likely if low Vitamin D AND K – Sept 2016
- Low Vitamin D or Vitamin K2 may be a cause of Hypertension and Osteoporosis – Nov 2012
• Vitamin D deficiency is severe worldwide and has become a major public health problem in all age groups.
• This meta-analysis included seven randomized controlled trials that examined whether vitamin D supplementation can affect blood pressure parameters in 560 vitamin D–deficient participants.
• There is a small but significant fall in peripheral blood pressure through vitamin D supplementation in vitamin D–deficient subjects.
• Central blood pressure parameters cannot be significantly affected by vitamin D supplementation.
Evidence suggests that supplementation of vitamin D cannot decrease blood pressure in normal populations. However, in randomized controlled trials (RCTs) with vitamin D deficient participants (defined as baseline serum 25[OH]D levels <30 ng/mL or 50 nmol/L), this effect is inconsistent and under debate. Thus, we performed this systematic review and meta-analysis to evaluate whether vitamin D supplementation could affect blood pressure parameters in vitamin D–deficient subjects. The PubMed, Web of Science, ScienceDirect, and Cochrane library databases were searched. Extracted data were pooled as weighted mean differences with 95% confidence intervals to evaluate the effects. Subgroup analysis was further conducted according to the characteristics of included studies. Seven RCTs that contained 560 participants were included in our meta-analysis. The pooled weighted mean difference of peripheral diastolic blood pressure was −1.65 mm Hg (95% confidence interval: −3.05 to −0.25, I2 = 30.3%). No significant effect of vitamin D supplementation was found on other parameters. Subgroup analysis showed a significant decrease in peripheral systolic blood pressure and diastolic blood pressure in Asia, 8 weeks of intervention, and more than 5000 IU of daily vitamin D supplementation subgroups. For vitamin D–deficient patients, there is a small but significant fall in peripheral blood pressure but no significant fall in other blood pressure parameters with vitamin D supplementation. Further RCTs with large numbers of participants is still warranted to confirm these effects.
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