The effect of vitamin D3 on blood pressure in people with vitamin D deficiency: A system review and meta-analysis.
Medicine (Baltimore). 2019 May;98(19):e15284. doi: 10.1097/MD.0000000000015284.
He S, Hao X.
- Blood pressure reduced by monthly 100,000 IU of vitamin D in those who were deficient – RCT Oct 2017
- Hypertension risk decreased 10X by increasing vitamin D levels to more than 40 ng – Nov 2017
This study does not appeared to have considered diabetics
- Vitamin D reduced only the systolic blood pressure in T2DM – Meta-analysis April 2019
- Blood pressure in diabetics reduced by 12 weekly doses of 50,000 IU vitamin D – RCT Jan 2014
- Pre-diabetes and hypertension 2.4X more common when less than 30 ng of vitamin D – Jan 2011
This study does not appeared to have considered hypertension and strokes
- Vascular dementia (after strokes) 32X more likely in Hypertensives with low vitamin D – Oct 2015
- Stroke is 13.5 X more likely if low vitamin D and high blood pressure – March 2015
This study does not appeared to have considered hypertension during pregnancies
Wonder if the meta-analysis on this page failed to consider the dose size (a common oversight)
Hypertension category listing contains the following
see also
Overview Overview Hypertension and Vitamin D
Overview Cardiovascular and vitamin D
Overview Stroke and vitamin D
Incidence of 22 health problems related to vitamin D have doubled in a decade
Some interesting Hypertension studies
- Hypertension risk decreased 10X by increasing vitamin D levels to more than 40 ng – Nov 2017
- COVID-19 deaths 4 to 7 X more likely if Diabetic, Hypertensive, or CVD - meta-analysis March 2020
- Magnesium reduces hypertension - FDA allows claim - Jan 2022
- Drug-resistant hypertension 3.5 X more likely if low vitamin D – March 2020
- High Blood Pressure reduced by Vitamin D supplementation in seniors and obese – meta-analysis May 2019
- Blood pressure in diabetics reduced by 12 weekly doses of 50,000 IU vitamin D – RCT Jan 2014
- Hypertension is associated with low vitamin D in some groups – meta-analysis April 2015
- Off Topic – Hypertension in 42 percent of adults (new definition: 130 mm Hg) – Feb 2018
- Men aged 40-59 59%, age >60 75%: National Health and Nutrition Examination Survey, 2017–2018
Items in both categories Hypertension and Meta-analyses are listed here:
- Preeclampsia reduced by 33 percent if high vitamin D – meta-analysis Feb 2023
- Blood pressure reduced if take more than 4.5 grams of Omega-3 daily– umbrella meta-analysis Aug 2022
- Low Vitamin D associated with preeclampsia - meta-analysis Feb 2022
- Low Vitamin D associated with pre-eclampsia -40th meta-analysis – Feb 2022
- Vitamin D does not reduce blood pressure in healthy people (no hypertension, etc) – Meta-analysis Jan 2020
- High Blood Pressure reduced by Vitamin D supplementation in seniors and obese – meta-analysis May 2019
- Vitamin D reduced only the systolic blood pressure in T2DM – Meta-analysis April 2019
- Hypertension not reduced much if use less than 5,000 IU of Vitamin D – meta-analysis June 2018
- Preeclampsia reduced 2X by Vitamin D, by 5X if also add Calcium – meta-analysis Oct 2017
- Preeclampsia risk reduced 60 percent if supplement with Vitamin D (they ignored dose size) – meta-analysis Sept 2017
- Blood pressure is reduced by more than 800 IU of vitamin D – meta-analysis Aug 2016
- Hypertension is associated with low vitamin D in some groups – meta-analysis April 2015
- Hypertension reduced by Omega-3, especially if previously untreated – meta-analysis July 2014
- Probiotics reduces blood pressure, but not as much as vitamin D does – meta-analysis July 2014
- Hypertension associated with genes which reduce vitamin D – meta-analysis June 2014
- Preeclampsia rate cut in half by high level of vitamin D – meta-analysis March 2014
- Preeclampsia 2.7X more frequent if low vitamin D – meta-analysis Sept 2013
- 2X more preeclampsia when vitamin D less than 30 ng, etc. - meta-analysis March 2013
- Hypertension 30 percent more likely if low vitamin D – meta-analysis March 2013
- Metabolic Syndrome in children is associated with low vitamin D – review Jan 2013
- Vitamin D associated with 50 percent less ischemic stroke – meta-analysis Aug 2012
- Hypertension 2X more likely when vitamin D levels lower than 14 ng – meta-analysis May 2012
- Meta-analysis found hypertension reduced with vitamin D – Dec 2010
OBJECTIVE:
To evaluate the effect of vitamin D3 on blood pressure in people with vitamin D deficiency.
METHODS:
Randomized controlled trials (RCTs) were electronically searched databases including CNKI, VIP, WanFang Data, the Cochrane Library, PubMed, and EMbase which were about oral vitamin D3 among people with vitamin D deficiency from inception to December 2017. Two reviewers independently screened literature according to the inclusion and extracted data; meta-analysis was performed using RevMan5.3.
RESULTS:
A total of 17 RCTs with 22 arms involving 1687 participants were included. The results of meta-analysis showed that, there were no significant differences between the vitamin D deficiency group and the control group on the level of change in systolic pressure (ΔSBP) [weighted mean difference (WMD) = -1.94, 95% confidence interval (CI) (-3.93,0.04) P = .06] and on the level of change in diastolic pressure (ΔDBP) [WMD = -0.50, 95% CI (-1.17, 0.17) P = .14]. The results of subgroups showed that, there were statistically significant differences in the age of >50 years subgroup on ΔSBP [WMD = -2.32, 95% CI (-4.39, -0.25) P = .03]; there were statistically significant differences in the hypertension subgroup on ΔSBP [WMD = -6.58, 95% CI (-8.72, -4.44) P <.00001]; there were statistically significant differences in the hypertension subgroup on ΔDBP [WMD = -3.07, 95% CI (-4.66, -1.48) P = .0002]; there were statistically significant differences in the body mass index (BMI) >30 subgroup on ΔSBP [WMD = -3.51, 95% CI (-5.96, -1.07) P = .005].
CONCLUSION:
Oral vitamin D3 has no significant effect on blood pressure in people with vitamin D deficiency. It reduces systolic blood pressure in people with vitamin D deficiency that was older than 50 years old or obese. It reduces systolic blood pressure and diastolic pressure in people with both vitamin D deficiency and hypertension.
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