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High Blood Pressure reduced by Vitamin D supplementation in seniors and obese – meta-analysis May 2019

The effect of vitamin D3 on blood pressure in people with vitamin D deficiency: A system review and meta-analysis.

Medicine (Baltimore). 2019 May;98(19):e15284. doi: 10.1097/MD.0000000000015284.
He S, Hao X.

VitaminDWiki

This study does not appeared to have considered diabetics

This study does not appeared to have considered hypertension and strokes

This study does not appeared to have considered hypertension during pregnancies

Wonder if the meta-analysis on this page failed to consider the dose size (a common oversight)


Hypertension category listing contains the following

124 items in the category HYPERTENSION

see also
Overview Hypertension and vitamin D
Overview Cardiovascular and vitamin D
Overview Stroke and vitamin D
Incidence of 30 health problems related to vitamin D has doubled in a decade
160% increase per decade (women, age adjusted)
Image


Items in both categories Hypertension and Meta-analyses are listed here:


OBJECTIVE:
To evaluate the effect of vitamin D3 on blood pressure in people with vitamin D deficiency.

METHODS:
Randomized controlled trials (RCTs) were electronically searched databases including CNKI, VIP, WanFang Data, the Cochrane Library, PubMed, and EMbase which were about oral vitamin D3 among people with vitamin D deficiency from inception to December 2017. Two reviewers independently screened literature according to the inclusion and extracted data; meta-analysis was performed using RevMan5.3.

RESULTS:
A total of 17 RCTs with 22 arms involving 1687 participants were included. The results of meta-analysis showed that, there were no significant differences between the vitamin D deficiency group and the control group on the level of change in systolic pressure (ΔSBP) [weighted mean difference (WMD) = -1.94, 95% confidence interval (CI) (-3.93,0.04) P = .06] and on the level of change in diastolic pressure (ΔDBP) [WMD = -0.50, 95% CI (-1.17, 0.17) P = .14]. The results of subgroups showed that, there were statistically significant differences in the age of >50 years subgroup on ΔSBP [WMD = -2.32, 95% CI (-4.39, -0.25) P = .03]; there were statistically significant differences in the hypertension subgroup on ΔSBP [WMD = -6.58, 95% CI (-8.72, -4.44) P <.00001]; there were statistically significant differences in the hypertension subgroup on ΔDBP [WMD = -3.07, 95% CI (-4.66, -1.48) P = .0002]; there were statistically significant differences in the body mass index (BMI) >30 subgroup on ΔSBP [WMD = -3.51, 95% CI (-5.96, -1.07) P = .005].

CONCLUSION:
Oral vitamin D3 has no significant effect on blood pressure in people with vitamin D deficiency. It reduces systolic blood pressure in people with vitamin D deficiency that was older than 50 years old or obese. It reduces systolic blood pressure and diastolic pressure in people with both vitamin D deficiency and hypertension.

Created by admin. Last Modification: Wednesday May 15, 2019 12:00:36 GMT-0000 by admin. (Version 4)
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