The Association between Serum 25(OH)D Status and Blood Pressure in Participants of a Community-Based Program Taking Vitamin D Supplements
Nutrients 2017, 9(11), 1244; doi:10.3390/nu9111244
Naghmeh Mirhosseini 1, Hassanali Vatanparast 2, and Samantha M. Kimball 1,*
1 Pure North S’Energy Foundation, Calgary, AB T2R 0C5, Canada
2 College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK S7N 5C9, Canada
- Blood pressure in diabetics reduced by 12 weekly doses of 50,000 IU vitamin D – RCT Jan 2014
- Daily average of 3600 IU Vitamin D helped hypertensives – Jan 2013
- Stroke is 13.5 X more likely if low vitamin D and high blood pressure – March 2015
- Blood pressure reduced by monthly 100,000 IU of vitamin D in those who were deficient – RCT Oct 2017
- Hypertension 5 X more likely if low Vitamin D, A, Calcium and Magnesium – June 2016
- Hypertension not reduced by drugs (Resistant Hypertension) in patients with low vitamin D
- Hypertension not reduced much if use less than 5,000 IU of Vitamin D – meta-analysis June 2018
Hypertension category listing contains the following
Overview Hypertension and vitamin D
Overview Cardiovascular and vitamin D
Overview Stroke and vitamin D
Incidence of 22 health problems related to vitamin D have doubled in a decade
160% increase per decade (women, age adjusted)
Background: Vitamin D deficiency is a risk factor for hypertension.
Methods: We assessed 8155 participants in a community-based program to investigate the association between serum 25-hydroxyvitamin D (25(OH)D) status and blood pressure (BP) and the influence of vitamin D supplementation on hypertension. Participants were provided vitamin D supplements to reach a target serum 25(OH)D > 100 nmol/L. A nested case-control study was conducted to examine the effect of achieving physiological vitamin D status in those who were hypertensive and not taking BP-lowering medication, and hypertensive participants that initiated BP-lowering medication after program entry.
Results: At baseline, 592 participants (7.3%) were hypertensive; of those, 71% were no longer hypertensive at follow-up (12 ± 3 months later). There was a significant negative association between BP and serum 25(OH)D level (systolic BP: coefficient = −0.07, p < 0.001; diastolic BP: coefficient = −0.1, p < 0.001). Reduced mean systolic (−18 vs. −14 mmHg) and diastolic (−12 vs. −12 mmHg) BP, pulse pressure (−5 vs. −1 mmHg) and mean arterial pressure (−14 vs. −13 mmHg) were not significantly different between hypertensive participants who did and did not take BP-lowering medication.
Conclusion: Improved serum 25(OH)D concentrations in hypertensive individuals who were vitamin D insufficient were associated with improved control of systolic and diastolic BP.
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“After correcting for probable confounding factors. . . only those participants that were vitamin D insufficient at baseline that achieved optimal serum 25(OH)D status at follow-up (≥100 nmol/L) had a lower risk of hypertension (OR = 0.10, 95% CI: 0.01, 0.87, p = 0.03).”
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