Vitamin D and mortality: meta-analysis of individual participant data from a large consortium of cohort studies from Europe and the United States
BMJ 2014; 348 doi: http://dx.doi.org/10.1136/bmj.g3656 (Published 17 June 2014)
Ben Schöttker, postdoctoral scientist1, Rolf Jorde, professor23, Anne Peasey, postdoctoral scientist4, Barbara Thorand, senior researcher in epidemiology5, Eugène H J M Jansen, postdoctoral scientist6, Lisette de Groot, professor of nutrition and ageing7, Martinette Streppel, postdoctoral scientist7, Julian Gardiner, research associate4, José Manuèl Ordóñez-Mena, PhD candidate18, Laura Perna, postdoctoral scientist1, Tom Wilsgaard, professor9, Wolfgang Rathmann, senior researcher in epidemiology10, Edith Feskens, professor7, Ellen Kampman, professor7, Galatios Siganos, research associate9, Inger Njølstad, professor9, Ellisiv Bøgeberg Mathiesen, professor11, Růžena Kubínová, senior researcher12, Andrzej Pająk, professor13, Roman Topor-Madry, senior researcher13, Abdonas Tamosiunas, professor14, Maria Hughes, postdoctoral scientist15, Frank Kee, professor15, Martin Bobak, professor4, Antonia Trichopoulou, professor1617, Paolo Boffetta, professor1618, Hermann Brenner, professor1 on behalf of the Consortium on Health and Ageing: Network of Cohorts in Europe and the United States (CHANCES)
1Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany
2Tromsø Endocrine Research Group, Department of Clinical Medicine, University of Tromsø (UiT) the Arctic University of Norway, 9037 Tromsø, Norway
3Division of Internal Medicine, University Hospital of North Norway, 9038 Tromsø, Norway
4Department Epidemiology and Public Health, University College London, London WC1E 6BT, UK
5Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
6Laboratory for Health Protection Research, National Institute for Public Health and the Environment, 3720 BA Bilthoven, Netherlands
7Division of Human Nutrition, Wageningen University, 6700 EV Wageningen, Netherlands
8Network Aging Research (NAR), University of Heidelberg, Heidelberg, Germany
9Epidemiology of Chronic Diseases Research Group, Department of community medicine, UiT the Arctic University of Norway, 9037 Tromsø, Norway
10German Diabetes Center, Institute for Biometrics and Epidemiology, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany
11Brain and Circulation Research Group, Department of clinical medicine, UiT the Arctic University of Norway, 9037 Tromsø, Norway
12National Institute of Public Health, Prague, Czech Republic
13Jagiellonian University Medical College, Faculty of Health Sciences, Krakow, Poland
14Institute of Cardiology of Lithuanian University of Health Sciences, Kaunas, Lithuania
15UKCRC Centre of Excellence for Public Health, Queens University Belfast, Northern Ireland, UK
16Hellenic Health Foundation, Kaisareias 13 & Alexandroupoleos, Athens 11527, Greece
17University of Athens, Medical School, Department of Hygiene, Epidemiology and Medical Statistics, Mikras Asias 75 st, Athens 11527, Greece
18Institute for Translational Epidemiology and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Correspondence to: B Schöttker b.schoettker at dkfz.de
Objective To investigate the association between serum 25-hydroxyvitamin D concentrations (25(OH)D) and mortality in a large consortium of cohort studies paying particular attention to potential age, sex, season, and country differences.
Design Meta-analysis of individual participant data of eight prospective cohort studies from Europe and the US.
Setting General population.
Participants 26 018 men and women aged 50-79 years
Main outcome measures All-cause, cardiovascular, and cancer mortality.
Results 25(OH)D concentrations varied strongly by season (higher in summer), country (higher in US and northern Europe) and sex (higher in men), but no consistent trend with age was observed.
During follow-up, 6695 study participants died, among whom 2624 died of cardiovascular diseases and 2227 died of cancer.
For each cohort and analysis, 25(OH)D quintiles were defined with cohort and subgroup specific cut-off values.
Comparing bottom versus top quintiles resulted in a pooled risk ratio of 1.57 (95% CI 1.36 to 1.81) for all-cause mortality.
Risk ratios for cardiovascular mortality were similar in magnitude to that for all-cause mortality in subjects both with and without a history of cardiovascular disease at baseline.
With respect to cancer mortality, an association was only observed among subjects with a history of cancer (risk ratio, 1.70 (1.00 to 2.88)).
Analyses using all quintiles suggest curvilinear, inverse, dose-response curves for the aforementioned relationships.
No strong age, sex, season, or country specific differences were detected. Heterogeneity was low in most meta-analyses.
Conclusions Despite levels of 25(OH)D strongly varying with country, sex, and season, the association between 25(OH)D level and all-cause and cause-specific mortality was remarkably consistent. Results from a long term randomised controlled trial addressing longevity are being awaited before vitamin D supplementation can be recommended in most individuals with low 25(OH)D levels.
PDF is attached at the bottom of this page
- All items in category Mortality and Vitamin D
- 1.9 X more likely to die if very low vitamin D – June 2014
- Sun avoidance increases risk of death by 2X – April 2014
- Dr. Grant on vitamin D and mortality in VitaminDWiki
- Mortality and vitamin D – great chart which has the following
The TOP MORTALITY articles are here:
- Prevent a COVID death: 9 dollars of Vitamin D or 900,000 dollars of vaccine - Aug 2023
- COVID survival in Europe in 2020 best predicted by population-level Vitamin D (of 13 variables) – July 2022
- 18 million excess global deaths in past 2 years: COVID plus collateral damage - Lancet March 2022
- Pop quiz: What is the percentage decrease in deaths by a Vitamin D increase of 10 nmol
- Those raising Vitamin D above 30 ng were 1.4 X less likely to die of Heart Attack (VA 19 years) – Oct 2021
- COVID-19 mortality extrapolates to zero at 50 ng of vitamin D – 18th Meta-analysis Sept 2021
- Longevity expert (David Sinclair) supplements includes Vitamin D, Vitamin K, and Resveratrol – Sept 2019
- Which Is Worse - Avoiding Sunlight or Vitamin D Deficiency – April 2019
- Vitamin D reduced Breast Cancer mortality in 9 out of 9 studies, yet still no consensus – April 2019
- Low Vitamin D is associated with dying sooner (70 studies) – meta-analysis Jan 2019
- Vitamin D reduces the risk of Breast Cancer, improves treatment, and improves survival
- Telomeres in boys were 2.5% longer if 9 ng higher vitamin D – July 2018
- Vitamin D - at least 4,000 IU to achieve 40-60 ng and reduce risk of early death – Holick June 2018
- Death within 2 years of surviving an ischemic stroke 10X less likely if high vitamin D – July 2017
- Causes of Death - Vitamin D reduces 10 of the top 11 - July 2017
- 2.4 times more likely to die if low Vitamin D (11,000 people for 14 years) – Sept 2016
- Vitamin D extends lifespan about 60 percent (for worms in a lab) – Oct 2016
- Vitamin D and exercise after hip fracture surgery – far fewer deaths – July 2016
- All-cause mortality is related to low Magnesium, rather than low Vitamin D – April 2015
- Chance of dying of various conditions reduced by higher levels of vitamin D – May 2015
- Vitamin D intervention increased by 20 percent the survival of critically ill patients- RCT June 2014
- 1.9 X more likely to die if very low vitamin D – June 2014
- Fewer heart attacks, hip fractures and deaths if more skin cancer – Sept 2013
- 3X more likely to die within 3 months of being in ICU for 2 days if less than 20 ng vitamin D – Sept 2013
- Why do gardeners live longer (vitamin D, etc.)
- Chance of dying increases by 25 percent in seniors if low vitamin D – Meta-analysis July 2013
- More sepsis deaths when active vitamin D (Calcitrol) was low – May 2013
- Vitamin D protects against many types of health problems – review May 2013
- Almost 6X more likely to die after coronary bypass if vitamin D deficient – Dec 2012
Less likely to die if have enough vitamin D - Meta-analysis June 2014
- Association between vitamin D deficiency and mortality in critically ill adult patients: a meta-analysis of cohort studies Dec 2014
OR 1.76, very similar to study on this page
6080 visitors, last modified 17 Dec, 2014,This page is in the following categories (# of items in each category)