Toggle Health Problems and D

Magnesium increases Vitamin D and decreases mortality - 2013

Magnesium, vitamin D status and mortality: results from US National Health and Nutrition Examination Survey (NHANES) 2001 to 2006 and NHANES III

BMC Medicine201311:187, DOI: 10.1186/1741-7015-11-187
© Deng et al.; licensee BioMed Central Ltd. 2013
Xinqing Deng, Yiqing Song, JoAnn E Manson, Lisa B Signorello, Shumin M Zhang, Martha J Shrubsole, Reid M Ness, Douglas L Seidner and Qi Da
http://is.gd/MgVitaminD 2013
Magnesium plays an essential role in the synthesis and metabolism of vitamin D and magnesium supplementation substantially reversed the resistance to vitamin D treatment in patients with magnesium-dependent vitamin-D-resistant rickets. We hypothesized that dietary magnesium alone, particularly its interaction with vitamin D intake, contributes to serum 25-hydroxyvitamin D (25(OH)D) levels, and the associations between serum 25(OH)D and risk of mortality may be modified by magnesium intake level.

We tested these novel hypotheses utilizing data from the National Health and Nutrition Examination Survey (NHANES) 2001 to 2006, a population-based cross-sectional study, and the NHANES III cohort, a population-based cohort study. Serum 25(OH)D was used to define vitamin D status. Mortality outcomes in the NHANES III cohort were determined by using probabilistic linkage with the National Death Index (NDI).

High intake of total, dietary or supplemental magnesium was independently associated with significantly reduced risks of vitamin D deficiency and insufficiency respectively.

  • Intake of magnesium significantly interacted with intake of vitamin D in relation to risk of both vitamin D deficiency and insufficiency.
  • Additionally, the inverse association between total magnesium intake and vitamin D insufficiency primarily appeared among populations at high risk of vitamin D insufficiency.
  • Furthermore, the associations of serum 25(OH)D with mortality, particularly due to cardiovascular disease (CVD) and colorectal cancer, were modified by magnesium intake, and the inverse associations were primarily present among those with magnesium intake above the median.

Our preliminary findings indicate it is possible that magnesium intake alone or its interaction with vitamin D intake may contribute to vitamin D status. The associations between serum 25(OH)D and risk of mortality may be modified by the intake level of magnesium. Future studies, including cohort studies and clinical trials, are necessary to confirm the findings.

 Download the PDF from VitaminDWiki

227 studies referenced this study as of Jan 2024

Google Scholar

  • Beneficial effects of adding magnesium to desalinated drinking water on metabolic and insulin resistance parameters among patients with type 2 diabetes mellitus: a randomized controlled clinical trial - Nov 2022 FREE PDF 50 mg of Magnesium per liter helped a lot
  • Magnesium: Biochemistry, Nutrition, Detection, and Social Impact of Diseases Linked to Its Deficiency - March 2021 10.3390/nu13041136 FREE PDF
  • Magnesium in Infectious Diseases in Older People - Jan 2021
  • The Role of Magnesium in the Pathogenesis of Metabolic Disorders April 2022 - FREE PDF
  • Vitamin D, Magnesium and Their Interactions: A Review - Sept 2021 10.30476/ijns.2021.91766.1144|FREE PDF]
  • Magnesium and Microelements in Older Persons 168 pages 2021 PDF

VitaminDWiki - Magnesium and Vitamin D contains the following highlights

343 items in category, see also

Mg and Vitamin D

Dr. Dean

Number of studies in both of the categories of Magnesium and:

Bone 15,  Cardiovascular 17,   Diabetes 27. Depression 14,  Obesity 11,   Omega-3 34,  Zinc 23,  Pregnancy 10,  Headache 11,   Virus 25,   Calcium 26   Virus 25   Mortality 9   Hypertension 11   Inflammation 3   Pain 7 etc.

Pages in BOTH the categories Magnesium and Mortality

See also in VitaminDWiki

8778 visitors to this page since it was originally made


Created by admin. Last Modification: Friday January 26, 2024 14:05:11 GMT-0000 by admin. (Version 25)

Attached files

ID Name Comment Uploaded Size Downloads
18595 Magnesium_and_Microelements_in_Older_Persons_CompressPdf.pdf admin 08 Oct, 2022 2.10 Mb 120
6358 Mg VitD Mortality.pdf admin 23 Jan, 2016 226.25 Kb 1357