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Patients on Hemodialysis 3X more likely if die of heart failure if low Magnesium – meta-analysis Jan 2021

Prognostic Value of Serum Magnesium in Mortality Risk among Patients on Hemodialysis: A Meta-Analysis of Observational Studies

Kidney Dis (Basel). 2021 Jan;7(1):24-33. doi: 10.1159/000510513
Hongwei Wu 1, Qiang Li 2, Lijing Fan 1, Dewang Zeng 1 3, Xianggeng Chi 4 5, Baozhang Guan 1, Bo Hu 1, Yongping Lu 1 5, Chen Yun 5, Bernhard Krämer 5, Berthold Hocher 1 5, Fanna Liu 1, Lianghong Yin 1

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Background: Previous studies have reported that serum magnesium (Mg) deficiency is involved in the development of heart failure, particularly in patients with end-stage kidney disease. The association between serum Mg levels and mortality risk in patients receiving hemodialysis is controversial. We aimed to estimate the prognostic value of serum Mg concentration on all-cause mortality and cardiovascular mortality in patients receiving hemodialysis.

Methods: We did a systematic literature search in PubMed, EMBASE, Cochrane Library, and Web of Science to identify eligible studies that reported the prognostic value of serum Mg levels in mortality risk among patients on hemodialysis. We performed a meta-analysis by pooling and analyzing hazard ratios (HRs) and 95% confidence intervals (CIs).

Results: We identified 13 observational studies with an overall sample of 42,967 hemodialysis patients. Higher all-cause mortality (adjusted HR 1.58 [95% CI: 1.31-1.91]) and higher cardiovascular mortality (adjusted HR 3.08 [95% CI: 1.27-7.50]) were found in patients with lower serum Mg levels after multivariable adjustment. There was marked heterogeneity ( I 2 = 79.6%, p < 0.001) that was partly explained by differences in age stratification and study area. In addition, subgroup analysis showed that a serum Mg concentration of ≤1.1 mmol/L might be the vigilant cutoff value.


Created by admin. Last Modification: Friday March 26, 2021 21:57:47 GMT-0000 by admin. (Version 6)

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15329 Dialysis cardio.jpg admin 26 Mar, 2021 21:40 57.19 Kb 19
15328 Mg heart failure dialysis.pdf PDF 2021 admin 26 Mar, 2021 21:40 458.99 Kb 11
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