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Ulcerative Colitis treated 4X better when Vitamin D was added – Meta-Analysis – July 2022

Efficacy and Safety of Vitamin D Adjuvant Therapy for Ulcerative Colitis: A Meta-Analysis

Comput Math Methods Med. 2022 Jul 20;2022:6836942. doi: 10.1155/2022/6836942. eCollection 2022.
Xinyi Guo 1, Changxing Liu 1, Yahui Huang 2

Objective: To examine the clinical efficacy and safety of Vitamin D in the treatment of ulcerative colitis in a systematic manner.

Methods: RCT studies on Vitamin D in the treatment of ulcerative colitis were searched from CNKI, Wanfang Data, PubMed, Cochrane Library, and Web of Science databases. RevMan 5.4 software was used for analysis.

Results: 10 articles were included, including 1077 patients. Meta-analysis results showed that when clinical efficacy was used as the outcome index, the clinical efficacy of the oral vitamin group was higher than that of the conventional treatment group (OR = 4.07, 95% CI 2.64-6.27), and the difference was statistically significant (Z = 6.38, P < 0.00001). When the Mayo risk score was used as the outcome index, the difference was statistically significant, indicating that oral Vitamin D significantly reduced the Mayo risk score (MD: -0.41, CI = (-0.47, -0.34), Z = 13.09, P < 0.00001). Using the intestinal mucosal barrier as the outcome index, the results showed that (1) the MDA group (MD = -0.75, 95% CI (-0.96~-0.53), P < 0.00001), (2) the DAO group (MD = -1.17, 95% CI (-1.39-0.95), P < 0.00001), and the Vitamin D group could effectively improve intestinal mucosal barrier function after sensitivity analysis (MD = -1.00, 95% CI (-1.08-0.92), P < 0.00001). When inflammatory factors were used as outcome indicators, IL-6, TNF-α, and CRP groups had statistical significance (MD = -4.50, 95% CI (-5.13-3.87), P < 0.00001); MD = -7.27, 95% CI (18.96-5.58), P < 0.00001; and MD = -1.49, 95% CI (-1.76~-1.23), P < 0.00001, respectively). When the incidence of adverse reactions was used as the outcome indicator (OR = 0.73, 95% CI (0.34-1.32), P = 0.23), there was no significant difference between the two groups.

Conclusion: Vitamin D combined with mesalazine is effective in the treatment of ulcerative colitis, by improving the Mayo score and intestinal barrier function, and reducing inflammatory factors, with no significant safety difference. However, due to the quality of the included researches, more RCT researches needed to provide sufficient evidence to support clinical application. This study is registered with INPLASY 202250044.
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Vitamin D pages with "Ulcerative Colitis" or UC in the title (12 as of Aug 2022)

Items found: 12

Vitamin D enema treats proctitis of the wife of the founder of VitaminDWiki

We made our own using 200,000 IU Vitamin D nanoemulsion + 1 liter of water + a pinch of salt
Image from IBD Releif

Created by admin. Last Modification: Friday August 5, 2022 16:34:25 GMT-0000 by admin. (Version 6)

Attached files

ID Name Comment Uploaded Size Downloads
18226 types_of_uc.jpg admin 01 Aug, 2022 16:13 135.48 Kb 40
18225 UC2.jpg admin 01 Aug, 2022 15:42 50.60 Kb 31
18224 UC meta.pdf PDF 2022 admin 01 Aug, 2022 15:34 840.69 Kb 7
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