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Breasts process Vitamin D and change gene activation, might prevent breast cancer if given more Vit. D – July 2021

Vitamin D as a potential preventive agent for young women's breast cancer

Cancer Prevention Research, DOI: 10.1158/1940-6207.CAPR-21-0114
Sarah M Bernhardt, Virgina F Borges and Pepper Schedin schedin at ohsu.edu

Clinical studies backed by research in animal models suggest that vitamin D may protect against the development of breast cancer, implicating vitamin D as a promising candidate for breast cancer prevention.

However, despite clear pre-clinical evidence showing protective roles for vitamin D, broadly targeted clinical trials of vitamin D supplementation have yielded conflicting findings, highlighting the complexity of translating pre-clinical data to efficacy in humans.

While vitamin D supplementation targeted to high-risk populations is a strategy anticipated to increase prevention efficacy, a complimentary approach is to target transient, developmental windows of elevated breast cancer risk. Postpartum mammary gland involution represents a developmental window of increased breast cancer promotion that may be poised for vitamin D supplementation.

Targeting the window of involution with short-term vitamin D intervention may offer a simple, cost-effective approach for the prevention of breast cancers that develop postpartum. In this review, we highlight epidemiologic and preclinical studies linking vitamin D deficiency with breast cancer development.

We discuss the underlying mechanisms through which vitamin D deficiency contributes to cancer development, with an emphasis on the anti-inflammatory activity of vitamin D. We also discuss current evidence for vitamin D as an immunotherapeutic agent and the potential for vitamin D as a preventative strategy for young woman's breast cancer

Section Titles
Overview of Vitamin D
Vitamin D signaling in breast cancer
Vitamin D in breast cancer progression and metastasis
Anti-inflammatory actions of vitamin D within the tumor microenvironment
Vitamin D as a therapeutic for the prevention of breast cancer
Targeting vitamin D to high-risk populations
Future research directions


There is strong evidence that downregulation of vitamin D signaling contributes to the development and progression of breast cancer. Epidemiological studies have linked vitamin D deficiency with an increased risk of breast cancer development; observations that are well-supported by research in animal models. However, while the potential for vitamin D as a breast cancer preventative agent is well-backed by pre-clinical data, clinical trials of vitamin D supplementation have produced modest and/or conflicting results. Vitamin D supplementation during transient, developmental windows of elevated risk may instead offer a more effective approach for the prevention of breast cancer. Post- lactational involution represents a key developmental window that may be poised for vitamin D supplementation. The unique demands for vitamin D during pregnancy and lactation emphasize vitamin D deficiency during the postpartum period, which in the background of the pro-inflammatory microenvironment of the involuting gland may enhance the tumor promotional attributes of involution. Attenuation of the inflammatory microenvironment of the vitamin D-deficient involuting breast with short-term vitamin D supplementation may offer protection against the development of postpartum breast cancer. Further research into the protective role of vitamin D against postpartum breast cancer development and progression is warranted.

 Download the PDF from VitaminDWiki

Note: This study indicates that Breast gets semiactivated Vitamin D p from the liver. Other studies indicate that the liver is not needed

Activating the Vitamin D Receptor increases Vitamin D


CYP27B1 increases Vitamin D


CYP24A1 decreases Vitamin D


Overview Breast Cancer and Vitamin D contains:

Getting Vitamin D into your body contains:


CYP27B1 category listing contains:

The CYP27B1 gene activates Vitamin D in the Kidney,    Skin,    Lungs,    Brain,   Eyes   Breasts   etc.
Poor CYP27B1 is assocated with COVID, Miscarriage,   Lupus,   Alz, Parkinson, MSA,   Rickets

CYtochrome P450 family 27 subfamily B member 1    = 25-Hydroxyvitamin D3 1-alpha-hydroxylase

What can be done if have a poor CYP27B1

  • Larger doses of Vitamin D
  • More Bio-available: Gut-friendly form, Topical form, taken with fatty meal, taken with evening meal
  • Additional sources: UV
  • Increase Vitamin D metabolism: additional Magnesium, Omega-3
    • All cytochrome P450 enzymes require Mg++ as a cofactor
  • Increase the amount of Vitamin D in the blood that gets to cells: increase activation of VDR

Vitamin D blood test misses CYP27B1 and other genes
in Visio for 2023

Cancers might alter CYP24A1 gene

The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019

VitaminDWiki - Vitamin D Receptor activation can be increased in many ways

Resveratrol,  Omega-3,  MagnesiumZinc,   Quercetin,   non-daily Vit D,  Curcumin,   Berberine,  intense exercise, Butyrate   Sulforaphane   Ginger,   Essential oils, etc  Note: The founder of VitaminDWiki uses 10 of the 16 known VDR activators

Items in both categories Vitamin D Receptor and Cancer - Breast:

Thus, the breasts try to increase receptor activation and Cancer cells try to decrease activation

Created by admin. Last Modification: Friday January 5, 2024 13:27:05 GMT-0000 by admin. (Version 13)

Attached files

ID Name Comment Uploaded Size Downloads
15894 Prevent CYP24A1.jpg admin 10 Jul, 2021 58.38 Kb 417
15893 Prevent CYP27B1.jpg admin 10 Jul, 2021 57.94 Kb 403
15892 Prevent VDR.jpg admin 10 Jul, 2021 58.58 Kb 403
15891 Prevent1.jpg admin 10 Jul, 2021 141.11 Kb 464
15890 prevent young women's breast cancer_compressed.pdf admin 10 Jul, 2021 329.53 Kb 309