Vitamin D supplementation reduces C-reactive protein and insulin resistance in women with type 2 diabetes mellitus
Mario Flores1, Simon Barquera2, Nayeli Macias1, Jorge Salmeron3, Andrew Greenberg4, Richard Wood6, Kurt Long7 and Simin Meydani5
FASEB (Federation of American Societies of Experimental Biology) Journal Vol 24 April 2010 342.1
1 Nutrition and Health Research Center
2 Division of Nutritional Epidemiology, National Institute of Public Health, Cuernavaca, Mexico
3 Epidemiology and Health Services Research Unit, Mexican Social Security Institute, Cuernavaca, Mexico
4 Obesity and Metabolism Research Laboratory, Jean Mayer USDA-HNRCA, Boston, MA
5 Jean Mayer USDA-HNRCA, Boston, MA
6 School of Public Health, UMASS Amherst, Amherst, MA
7 School of Population Health, University of Queensland, Brisbane, Australia
A randomized, double blind, placebo-controlled clinical trial was conducted to evaluate the effect of vitamin D supplementation on C-reactive protein (CRP) and insulin resistance in 104 postmenopausal women with type 2 diabetes mellitus. Participants received a vitamin D capsule –cholecalciferol 4,000 IU- (n=52) or placebo (n=52), daily during 6 mo. The study was approved by the Ethics committee at NIPH. All participants signed an informed consent.
Results: Median CRP concentration was 5.0 mg/L (ir: 1.0, 8.5).
HOMA index at baseline was 7.13 ± 3.8.
Serum 25-OH-D at baseline was 54.5 ± 15.7 nmol/L. 93% of patients had 25-OH-D levels <80 nmol/L, and 40% <50 nmol/L. Experimental groups were similar on most variables at baseline.
After 6 months, there was an increase in serum 25-OH-D of 25 ± 2.6 nmol/L in the supplemented group, and an increase of 0.8 ± 2.2 nmol/L in the placebo group (p<0.001).
There was a 64% reduction on CRP among supplemented women who had baseline CRP concentrations >5.0 mg/L (p<0.05).
A 24% reduction in HOMA-IR after 6 months was observed among supplemented women who had a baseline HOMA >6.0 (p=0.06).
Conclusion: Vitamin D supplementation during 6 months reduced CRP levels and insulin resistance among diabetic, postmenopausal women with high HOMA index and elevated CRP levels.
- Intervention - add vitamin D and see what happens
- Insulin sensitivity in obese adolescents greatly improved with 4000 IU of vitamin D - RCT April 2013 another RCT with good results
- Diabetes (Type II) reduced by single injection of 300,000 IU of vitamin D3 – RCT March 2014
- Slow gait is 3.5X more likely with low vitamin D and high C-Reactive Protein – Aug 2013
- Daily Magnesium improved all aspects of metabolic profile – RCT July 2014
- Overview Diabetes and vitamin D contains the following summary
- Diabetes is 5X more frequent far from the equator
- Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
- Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
- Sedentary people get less sun / Vitamin D
- Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
- Elderly get 4X less vitamin D from the same amount of sun
Elderly also spend less time outdoors and have more clothes on
- All items in category Diabetes and Vitamin D
413 items: both Type 1 and Type 2
Vitamin D appears to both prevent and treat diabetes
- Appears that >2,000 IU will Prevent
- Appears that >4,000 IU will Treat , but not cure
- Appears that Calcium and Magnesium are needed for both Prevention and Treatment
which are just some of the vitamin D cofactors
The TOP articles in Diabetes and Vitamin D are listed here:
- Prediabetes both prevented and treated by monthly Vitamin D, etc.
- Low Level Laser Therapy greatly increased Vitamin D and Magnesium (for diabetics with nephropathy) – March 2019
- Resveratrol improves health (Vitamin D receptor, etc.)
- Diabetes Prevention Program funded by many (Vitamin D would be much better) – Aug 2018
- Prediabetes treated by Vitamin D (34 ng, 3500 IU per day) – meta-analysis May 2018
- Maternal Diabetes and Risk of Autism in Offspring – JAMA June 2018
- Young Diabetics had 3.8 X higher risk of Parkinson’s (perhaps low Mg or low Vitamin D)– June 2018
- Vitamin D treatment of diabetes (50,000 IU every 2 weeks) augmented by probiotic – RCT June 2018
- Diabetics helped by vitamin D in 5 ways – meta-analysis June 2018
- Diabetes less likely 12 years later with Vitamin D – 50X if 30 ng of Vitamin D and intense exercise – April 2018
- Zinc cut in half the rate of prediabetes progressing to diabetes (20 mg) – RCT Oct 2017
- HbA1c levels (Diabetes) reduced by monthly 50,000 IU of vitamin D – Dec 2017
- Vitamin K2 substantially reduces risk of T2 Diabetes (7 percent for every 10 ug) – review Nov 2017
- Autoimmune diseases associated with low Vitamin D and Vitamin D Receptor – July 2017
- Diabetes treated if given enough vitamin D (example: 50,000 IU weekly) – review of RCT - Jan 2017
- ALL of the top 10 health problems of women are associated with low vitamin D
- Gestational Diabetes reduced with 50,000 IU of vitamin D every 3 weeks and daily Calcium – RCT June 2014
- Mice designed to get diabetes often failed to get diabetes if they had lots of vitamin D during their lives – Feb 2014
- Diabetes prevention RCT kicked off: adding 4,000 IU vitamin D - Oct 2013
- Type 1 diabetes starting to decrease in Finland, they started Vitamin D fortification in 2003 – July 2013
- Diabetics with low vitamin D had more cognitive impairment– Aug 2013
- Vitamin D protects against many types of health problems – review May 2013
- 4 percent less type 2 diabetes for every 4 ng more vitamin D – meta-analysis May 2013
- Dr. Holick video on vitamin D - March 2013
- Diabetic Neuropathy sometimes can be reversed by vitamin D
- Metabolic Syndrome 10% less likely for every 4 ng increase in Vitamin D – Jan 2013
- Metabolic Syndrome in children is associated with low vitamin D – review Jan 2013
- Timeline of Heart Disease, Diabetes, fats, lard, HFCS, and vitamin D – Aug 2012
- Diabetes 3.5X less likely if more than 25 ng Vitamin D – Sept 2012
- Probability of Type I diabetes reduced 29 percent with vitamin D – systematic review July 2012