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Zinc cut in half the rate of prediabetes progressing to diabetes (20 mg) – RCT Oct 2017

Zinc supplementation in prediabetes: A randomized double-blind placebo-controlled clinical trial.

J Diabetes. 2017 Oct 26. doi: 10.1111/1753-0407.12621. [Epub ahead of print]
Ranasinghe P1, Wathurapatha WS1, Galappatthy P1, Katulanda P2, Jayawardena R3,4, Constantine GR2.
1 Dept of Pharmacology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
2 Dept of Clinical Medicine, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
3 Dept of Physiology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
4 Institute of Health and Biomedical Innovation, Queensland Univ. of Technology, Brisbane, Queensland, Australia.


Excellent analysis of the study by Examine.com in Feb 2018


They also have a good backgrounder on Zinc and Health which includes

  • "Zinc has two standard dosages. The low dosage is 5-10mg, while the high dosage is 25-45mg. The low dose works well as a daily preventative, while the high dosage should be taken by anyone at risk for a zinc deficiency."
  • "Different forms of zinc contain different amounts of elemental zinc, which refers to the weight of the zinc molecule by itself"
  • "Zinc should be supplemented daily."
  • Consistant proof of benefits to diabetes, depression, acne, testosterone, viral warts (topical) , cognition after stroke, common cold

Note: The founder of VitaminDWiki subscribes to only 5 publications. Examine.com is one of them

 Download the Examine.com PDF from VitaminDWiki

See also VitaminDWiki

Overview Diabetes and vitamin D contains the following summary

  • Diabetes is 5X more frequent far from the equator
  • Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
  • Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
  • Sedentary people get less sun / Vitamin D
  • Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
  • Elderly get 4X less vitamin D from the same amount of sun
        Elderly also spend less time outdoors and have more clothes on
  • All items in category Diabetes and Vitamin D 480 items: both Type 1 and Type 2

Vitamin D appears to both prevent and treat diabetes

  • Appears that >2,000 IU will Prevent
  • Appears that >4,000 IU will Treat , but not cure
  • Appears that Calcium and Magnesium are needed for both Prevention and Treatment
    • which are just some of the vitamin D cofactors

Number of articles in both categories of Diabetes and:

  • Dark Skin 23;   Intervention 52;   Meta-analysis 34;   Obesity 28;  Pregnancy 40;   T1 (child) 37;  Omega-3 11;  Vitamin D Receptor 21;  Genetics 11;  Magnesium 19    Click here to see details

Diabetes category starts with the following

480 items In Diabetes category

see also Overview Diabetes and vitamin D  Overview Metabolic Syndrome and vitamin D

Autoimmune category listing has 177 items along with related searches

T1 diabetes OR type1 diabetes in title 107 as of April 2018
prediabetes OR prediabetic 1260 items as of April 2021
Search VitaminDWiki for Peripheral Neuropathy 238 items April 2018

Zinc and Vitamin D category listing has 69 items and the following

Zinc half life in the body - hours or 4 months?
http://garthkroeker.blogspot.com/2009/07/zinc-eating-disorders.html 4 months
others indicate take Zinc several times per day to stop a cold

Zinc and prediabetes on the web

This study evaluated the effects of zinc supplementation on glycemic control, other cardiometabolic and anthropometric parameters, and disease progression in prediabetes.

A randomized double-blind placebo-controlled Phase 2 clinical trial was conducted over a 12-month period in 200 subjects (43% male; mean [± SD] age 51.8 ± 7.3 years), randomly assigned (1:  1) to the treatment or control group. The treatment group received zinc (20 mg daily). Subjects were evaluated at baseline and at 1, 3, 6, and 12 months. The primary outcome was the change in glycemic control from baseline. Multiple regression analyses were performed, with change in outcome variables after intervention from baseline used as continuous dependent variables.

In both groups, mean serum zinc concentrations prior to the trial were below normal (15.29-21.41 μmol/L). During the 12-month follow-up, a significantly higher percentage of participants developed type 2 diabetes in the control compared with zinc-treated group (25.0% vs 11.0% respectively; P = 0.016).

  • Fasting plasma glucose (FPG),
  • 2-h glucose levels in the oral glucose tolerance test (OGTT),
  • homeostasis model assessment of insulin resistance (HOMA-IR),
  • total cholesterol (TC), and
  • low-density lipoprotein cholesterol (LDL-C)

were significantly lower in the treated group, with significant improvement in β-cell function. In all four regression models, the best predictor of the dependent variables (i.e. change in FPG, 2-h glucose in the OGTT, HOMA-IR, and homeostatic model assessment of β-cell function) was zinc treatment.

Zinc supplementation reduced blood glucose and insulin resistance while improving β-cell function. Furthermore, supplementation reduced disease progression to diabetes and had beneficial effects on TC and LDL-C.

PMID: 29072815 DOI: 10.1111/1753-0407.12621

Created by admin. Last Modification: Sunday February 24, 2019 21:23:33 GMT-0000 by admin. (Version 11)

Attached files

ID Name Comment Uploaded Size Downloads
9424 Pharmacokinetics of Zinc in Pre-Diabetes - A Pilot Study.pdf PDF 2018 admin 28 Feb, 2018 09:23 450.13 Kb 414
9423 Examine Zinc Diabetes.jpg admin 28 Feb, 2018 02:15 56.04 Kb 1374
9422 ERD Zinc Diabetes.pdf PDF 2018 admin 28 Feb, 2018 02:07 615.96 Kb 711
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