4000 IU RCT reduces type 2 diabetes HOMA by 24% and CRP by 64% April 2010

Vitamin D supplementation reduces C-reactive protein and insulin resistance in women with type 2 diabetes mellitus

Mario Flores1, Simon Barquera2, Nayeli Macias1, Jorge Salmeron3, Andrew Greenberg4, Richard Wood6, Kurt Long7 and Simin Meydani5
FASEB (Federation of American Societies of Experimental Biology) Journal Vol 24 April 2010 342.1
1 Nutrition and Health Research Center
2 Division of Nutritional Epidemiology, National Institute of Public Health, Cuernavaca, Mexico
3 Epidemiology and Health Services Research Unit, Mexican Social Security Institute, Cuernavaca, Mexico
4 Obesity and Metabolism Research Laboratory, Jean Mayer USDA-HNRCA, Boston, MA
5 Jean Mayer USDA-HNRCA, Boston, MA
6 School of Public Health, UMASS Amherst, Amherst, MA
7 School of Population Health, University of Queensland, Brisbane, Australia

A randomized, double blind, placebo-controlled clinical trial was conducted to evaluate the effect of vitamin D supplementation on C-reactive protein (CRP) and insulin resistance in 104 postmenopausal women with type 2 diabetes mellitus. Participants received a vitamin D capsule –cholecalciferol 4,000 IU- (n=52) or placebo (n=52), daily during 6 mo. The study was approved by the Ethics committee at NIPH. All participants signed an informed consent.

Results: Median CRP concentration was 5.0 mg/L (ir: 1.0, 8.5).
HOMA index at baseline was 7.13 ± 3.8.
Serum 25-OH-D at baseline was 54.5 ± 15.7 nmol/L. 93% of patients had 25-OH-D levels <80 nmol/L, and 40% <50 nmol/L. Experimental groups were similar on most variables at baseline.
After 6 months, there was an increase in serum 25-OH-D of 25 ± 2.6 nmol/L in the supplemented group, and an increase of 0.8 ± 2.2 nmol/L in the placebo group (p<0.001).
There was a 64% reduction on CRP among supplemented women who had baseline CRP concentrations >5.0 mg/L (p<0.05).
A 24% reduction in HOMA-IR after 6 months was observed among supplemented women who had a baseline HOMA >6.0 (p=0.06).

Conclusion: Vitamin D supplementation during 6 months reduced CRP levels and insulin resistance among diabetic, postmenopausal women with high HOMA index and elevated CRP levels.


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