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2400 IU Vitamin D daily to get 90% of children above 30 ng, etc. – Cashman April 2024

Meta-regression of 29 studies of children 0-4 years old
Study does not notice that
  4 year old needs about 4X more than newborn
  Obese need about 2X more
  Children who were preemies need about 2X more

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The relationship between vitamin D intake and serum 25-hydroxyvitamin D in young children: a meta-regression to inform WHO/FAO vitamin D intake recommendations

Journal of Nutrition https://doi.org/10.1016/j.tjnut.2024.04.031
Magali RIOS-LEYVRAZ, Laura Martino, Kevin D. CASHMAN

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Background
This work was commissioned by the WHO and FAO to inform their update of the vitamin D requirements for children below 4 years old.

Objective
The objective of this work was to undertake multi-level and multivariable dose-response modelling of serum 25OHD to total vitamin D intake in children below 4 years of age and to derive updated vitamin D requirements for young children.

Methods
Systematically identified randomized controlled trials among healthy children from 2 weeks up to 3.9 years of age provided with daily vitamin D supplements or vitamin D-fortified foods were included. Linear and non-linear random effects multi-level meta-regression models with and without covariates were fitted and compared. Inter-individual variability was included by simulating the individual serum 25OHD responses. The percentage of individuals reaching set minimal and maximal serum 25OHD thresholds were calculated and used to derive vitamin D requirements.

Results
A total of 31 trials with 186 data points, from North America, Europe, Asia and Australasia/Oceania, with latitudes ranging from 38°S to 61°N, and with participants of likely mostly light or medium skin pigmentation, were included; in 29 studies the children received vitamin D supplements and in two studies the children received vitamin D fortified milks with or without supplements. The dose-response relationship between vitamin D intake and serum 25OHD was best fitted with the unadjusted quadratic model; adding additional covariates, such as age, did not significantly improve the model. At a vitamin D intake of 10 μg/d, 97.3% of the individuals were predicted to achieve a minimal serum 25OHD threshold of 28 nmol/L. At a vitamin D intake of 35 μg/d, 1.4% of the individuals predicted to reach a maximal serum 25OHD threshold of 200 nmol/L.

Conclusions
In conclusion, this paper details the methodological steps taken to derive vitamin D requirements in children below 4 years of age, including the addition of an inter-individual variability component.
 Download the PDF from VitaminDWiki


VitaminDWiki - 10 studies in both categories Infant-Child and How Much

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VitaminDWiki - 46 studies in both categories Infant-Child and Deficiency

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VitaminDWiki – Predict Vitamin D category contains:

It is very difficult to predict the response to supplementation of Vitamin D, or additional sun/UV
There are a huge number of factors involved.
 
This page also has studies predicting deficiency without Vitamin D tests

Examples of 81 studies that Predict Vitamin D levels

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VitaminDWiki – Recommend 100 IU of vitamin D per kg of infant - Poland July 2011 - charts

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1000 IU per 25 lbs.jpg


VitaminDWiki - How you might double your response to vitamin D


VitaminDWiki - Overview Vitamin D Dose-Response


VitaminDWiki - Increased Vitamin D response if take cofactors, etc


VitaminDWiki - Consensus Vitamin D


VitaminDWiki - 24 Vitamin D global guidelines for children, huge diversity – Sept 2022


Attached files

ID Name Comment Uploaded Size Downloads
21144 Children dose response.webp admin 30 Apr, 2024 22.21 Kb 38
21143 Dose response - children.webp admin 30 Apr, 2024 28.76 Kb 35
21142 Dose response meta-regression_CompressPdf.pdf admin 30 Apr, 2024 472.20 Kb 43