25(OH)D Concentration in Neonates, Infants, and Toddlers From Poland—Evaluation of Trends During Years 1981–2011 - Nov 2018
Front. Endocrinol., 08 November 2018 | https://doi.org/10.3389/fendo.2018.00656
Marek Wójcik, Maciej Jaworski and Pawel Pludowski*
Department of Biochemistry, Radioimmunology and Experimental Medicine, The Children's Memorial Health Institute, Warsaw, Poland
- There are a great many reasons for the decreasing vitamin D levels - such as
- getting less vitamin D from the sun
- getting less vitamin D from food
- getting less Magnesium needed to get and use Vitamin D
- Reasons for Low Vitamin D and what to do
- Canada 6% drop in 2 years all ages, about 2X higher % for age 6-11
- 2X more people have less than :30 ng of vitamin D in a decade – Feb 2010
- 4,000 IU of Vitamin D is OK - 19 organizations agree - 2018
- Governments are increasing their Vitamin D recommendations about every decade.
- Their recommendations typically (mistakenly) consider the vitamin D levels to be static
- Dr. Hollick recommended 1000 IU in 2004, but a decade later recommends 3,500 IU
- Deficiency of Vitamin D category listing has
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- Soldiers need vitamin D, but levels cut in half in 18 years – March 2014 special operations forces
- Trial starting for Vitamin D with US soldiers – 2,000 and 5,000 IU for 3 months – Nov 2016
- Need for Routine Vitamin D Screening in Military Personnel – Sept 2016
- No military trainee consumed Vitamin D RDA (most were also low in Magnesium) – July 2018
- but frogs are not noticing the increasing problem
Note: Only a single data point for 1981-1999 - unable to see trends during it.
Introduction: The numerous evidence showing spectrum of vitamin D effects on human health resulted in both updates of vitamin D supplementation guidelines for general population and concerns on potential risk of hypercalcaemia. The aim of this study was to analyse trends in serum 25-hydroxyvitamin D concentration (25(OH)D) change over the 30 years of operation of a single pediatric diagnostic unit.
Materials and methods: Calcium-phosphate metabolism markers and 25(OH)D concentrations were analyzed in a group that consisted of newborns and infants commissioned for diagnostics due to suspected calcium-phosphate metabolic disturbances (n = 3,163; mean age 8.0 ± 3.0 months).
Results: 25(OH)D < 10 ng/ml was noted in 4.5% of patients (n = 163), 10–20 ng/ml in 14.7% (n = 465), 20–30 ng/ml in 23.9% (n = 756) and 30–50 ng/ml in 35.9% (n = 1,136). The mean 25(OH)D concentration in analyzed group was 37.5 ± 24.5 ng/ml. In patients with 25(OH)D concentration < 10 ng/ml a normal calcaemia (2.25–2.65 mmol/l) was noted in 83.4% cases (n = 136). Eighty one patients had 25(OH)D concentrations above 100 ng/ml with co-existing calcaemia in range of 2.6–4.38 mmol/l (mean Ca = 2.69 mmol/l). Hypocalcaemia (Ca < 2.25 mmol/l) was observed in 0.54%, (n = 17). 13.8% patients revealed calcium levels >2.65 mmol/l (n = 435). In general, the mean calcium-phosphate markers values were within the reference range for age. The highest mean 25(OH)D concentration of 51.8 ng/ml ± 38.8 was noted in years 1981–1999 (n = 305). The lowest mean 25(OH)D value was observed in years 2010–2011 (29.0 ng/ml ± 13.6; n = 412). The trend of decreasing 25(OH)D concentration during analyzed time period was significant (r = −0.29, p < 0.0001).
Conclusions: Eighty percent of children aged 0–36 months had 25(OH)D concentration >20 ng/ml, however, during 3 decades a mean 25(OH)D concentrations trended significantly to decrease. A direct relationship between low 25(OH)D concentration and hypocalcaemia was not observed nor between high 25(OH)D concentration and hypercalcemia.
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